Systems and methods for providing personalized estimates of bioheat transfer

Abstract

Systems and methods are disclosed for providing personalized estimates of bioheat transfer through a patient's body or a portion of a patient's body. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model including at least a portion of tissue of the patient's anatomy; receiving an estimate of heat content of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue; determining an estimate of heat distribution of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue based on the vascular model, the tissue model, or the received estimate of heat content; and output the determined estimate of heat distribution to a storage medium or user display.

1 - 20 . (canceled) 
     
     
         21 . A computer-implemented method of providing personalized estimates of bioheat transfer through a patient's body or a portion of a patient's body, the method comprising:
 receiving an estimate of heat content of a portion of a patient's tissue;   receiving blood flow information associated with the portion of the patient's tissue;   computing an estimate of heat transfer through the portion of the patient's tissue based on the received estimate of heat content and the received blood flow information;   computing an estimate of heat distribution of the portion of the patient's tissue or tissue surrounding the portion of the patient's tissue based on the determined estimate of heat transfer; and   outputting the determined estimate of heat distribution to a storage medium or user display.   
     
     
         22 . The computer-implemented method of  claim 21 , wherein the display includes renderings of heat distribution simulations, treatments, and/or interactive options or prompts to adjust circulation, temperature, patient tissue geometry, time frames to display. 
     
     
         23 . The computer-implemented method of  claim 21 , wherein the estimate of heat content is estimated as a homogenous value. 
     
     
         24 . The computer-implemented method of  claim 23 , further comprising:
 determining an introduction of a temperature source in a location of the tissue model or vascular model, wherein the estimate of heat content is homogenous except for the location of the temperature source.   
     
     
         25 . The computer-implemented method of  claim 24 , wherein the temperature source is associated with ablation, a heating apparatus, or a cooling apparatus. 
     
     
         26 . The computer-implemented method of  claim 21 , further comprising:
 determining, using the vascular model, blood flow demand of the tissue model.   
     
     
         27 . The computer-implemented method of  claim 21 , wherein the estimate of heat content of the portion of tissue comprises the heat content of the portion of tissue or the surrounding tissue at a first point of time; and
 wherein the estimate of heat distribution comprises heat distribution at a second point of time different from the first point of time.   
     
     
         28 . The computer-implemented method of  claim 21 , further comprising:
 receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; or   receiving a patient-specific tissue model including at least a portion of tissue of the patient's anatomy;   wherein the estimate of heat transfer or the estimate of heat distribution is based on the received patient-specific vascular model and/or the receive patient-specific tissue model.   
     
     
         29 . A system for providing personalized estimates of bioheat transfer through a patient's body or a portion of a patient's body, the system comprising:
 a data storage device storing instructions of providing personalized estimates of bioheat transfer through a patient's body or a portion of a patient's body; and   a processor configured to execute the instructions to perform a method including:
 receiving an estimate of heat content of a portion of a patient's tissue; 
 receiving blood flow information associated with the portion of the patient's tissue; 
 computing an estimate of heat transfer through the portion of the patient's tissue based on the received estimate of heat content and the received blood flow information; 
 computing an estimate of heat distribution of the portion of the patient's tissue or tissue surrounding the portion of the patient's tissue based on the determined estimate of heat transfer; and 
 outputting the determined estimate of heat distribution to a storage medium or user display. 
   
     
     
         30 . The system of  claim 29 , wherein the display includes renderings of heat distribution simulations, treatments, and/or interactive options or prompts to adjust circulation, temperature, patient tissue geometry, time frames to display. 
     
     
         31 . The system of  claim 29 , wherein the estimate of heat content is estimated as a homogenous value. 
     
     
         32 . The system of  claim 31 , wherein the system is further configured for:
 determining an introduction of a temperature source in a location of the tissue model or vascular model, wherein the estimate of heat content is homogenous except for the location of the temperature source.   
     
     
         33 . The system of  claim 32 , wherein the temperature source is associated with ablation, a heating apparatus, or a cooling apparatus. 
     
     
         34 . The system of  claim 29 , wherein the system is further configured for:
 determining, using the vascular model, blood flow demand of the tissue model.   
     
     
         35 . The system of  claim 29 , wherein the estimate of heat content of the portion of tissue comprises the heat content of the portion of tissue or the surrounding tissue at a first point of time; and
 wherein the estimate of heat distribution comprises heat distribution at a second point of time different from the first point of time.   
     
     
         36 . The system of  claim 29 , wherein the system is further configured for:
 receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; or   receiving a patient-specific tissue model including at least a portion of tissue of the patient's anatomy;   wherein the estimate of heat transfer or the estimate of heat distribution is based on the received patient-specific vascular model and/or the receive patient-specific tissue model.   
     
     
         37 . A non-transitory computer readable medium for use on a computer system containing computer-executable programming instructions for performing a method of providing personalized estimates of bioheat transfer through a patient's body or a portion of a patient's body, the method comprising:
 receiving an estimate of heat content of a portion of a patient's tissue;   receiving blood flow information associated with the portion of the patient's tissue;   computing an estimate of heat transfer through the portion of the patient's tissue based on the received estimate of heat content and the received blood flow information;   computing an estimate of heat distribution of the portion of the patient's tissue or tissue surrounding the portion of the patient's tissue based on the determined estimate of heat transfer; and   outputting the determined estimate of heat distribution to a storage medium or user display.   
     
     
         38 . The non-transitory computer readable medium of  claim 37 , wherein the display includes renderings of heat distribution simulations, treatments, and/or interactive options or prompts to adjust circulation, temperature, patient tissue geometry, time frames to display. 
     
     
         39 . The non-transitory computer readable medium of  claim 37 , wherein the estimate of heat content is estimated as a homogenous value. 
     
     
         40 . The non-transitory computer readable medium of  claim 39 , the method further comprising: 
       determining an introduction of a temperature source in a location of the tissue model or vascular model, wherein the estimate of heat content is homogenous except for the location of the temperature source.