US2019236983A1PendingUtilityA1

System and method for acoustic wave induced traumatic brain injury

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Assignee: CELL SURGICAL NETWORK CORPPriority: Jan 30, 2018Filed: May 31, 2018Published: Aug 1, 2019
Est. expiryJan 30, 2038(~11.5 yrs left)· nominal 20-yr term from priority
Inventors:Elliot B. Lander
A61B 5/4064G10K 9/12G09B 23/30G10K 11/26G09B 19/00G09B 23/28
41
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Claims

Abstract

Disclosed herein are systems and methods of generating traumatic brain injury. More specifically, the present disclosure relates to acoustic systems and methods for inflicting traumatic brain injury and developing an animal model of traumatic brain injury.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method of simulating traumatic brain injury (TBI) in a non-human animal model, the method comprising administering one or more acoustic waves to the brain of the animal with an acoustic wave generator, thereby resulting in brain trauma. 
     
     
         2 . The method of  claim 1 , wherein a single acoustic wave is administered to the brain of the animal. 
     
     
         3 . The method of  claim 1 , wherein the acoustic wave is administered at a pressure of 1.0-5.0 bar. 
     
     
         4 . The method of  claim 1 , wherein the acoustic wave is administered to one or more brain regions. 
     
     
         5 . The method of  claim 4 , wherein the brain region is the frontal motor cortex. 
     
     
         6 . The method of  claim 1 , wherein the non-human animal exhibits one or more of impaired cognitive function or impaired motor coordination resulting from the brain trauma. 
     
     
         7 . The method of  claim 1 , wherein the non-human animal model is a rodent. 
     
     
         8 . A non-human animal model of traumatic brain injury (TBI), wherein one or more acoustic waves are administered to the brain of the animal with an acoustic wave generator, and wherein the one or more acoustic waves induces brain trauma. 
     
     
         9 . The non-human animal model of TBI of  claim 8 , wherein a single acoustic wave is administered to the brain of the animal. 
     
     
         10 . The non-human animal model of TBI of  claim 8 , wherein the acoustic wave is administered at a pressure of 1.0-5.0 bar. 
     
     
         11 . The non-human animal model of TBI of  claim 8 , wherein the acoustic wave is administered to one or more brain regions. 
     
     
         12 . The non-human animal model of TBI of  claim 11 , wherein the brain region is the frontal motor cortex. 
     
     
         13 . The non-human animal model of TBI of  claim 8 , wherein the non-human animal model is a rodent. 
     
     
         14 . The non-human animal model of  claim 8 , wherein the animal exhibits cognitive impairment resulting from the brain trauma. 
     
     
         15 . The non-human animal model of  claim 8 , wherein the animal exhibits impaired motor skills resulting from the brain trauma. 
     
     
         16 . A system comprising an acoustic wave generator configured to produce acoustic waves resulting in brain trauma in a non-human animal. 
     
     
         17 . The system of  claim 16 , wherein a single acoustic wave is administered to the brain of the animal. 
     
     
         18 . The system of  claim 16 , wherein the acoustic wave is administered at a pressure of 1.0-5.0 bar. 
     
     
         19 . The system of  claim 16 , wherein the acoustic wave is administered to one or more brain regions. 
     
     
         20 . The system of  claim 19 , wherein the brain region is the frontal motor cortex.

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