US2019224380A1PendingUtilityA1

Compositions and methods for enhancing healing and regeneration of bone and soft tissue

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Assignee: SWEETBIO INCPriority: Aug 5, 2014Filed: Jan 16, 2019Published: Jul 25, 2019
Est. expiryAug 5, 2034(~8 yrs left)· nominal 20-yr term from priority
Inventors:Isaac Anthony RodriguezGary BowlinBrenton Walter Burger
A61P 17/00A61P 19/00A61L 27/24A61L 2300/406A61L 27/58A61L 2300/404A61L 27/222A61L 27/48A61L 27/46A61L 27/365A61L 27/3604A61L 2430/02A61L 2300/412A61L 27/54A61L 27/18A61L 27/26A61L 2300/30A61L 27/56A61L 27/12
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Claims

Abstract

The invention features biodegradable materials, and in vitro and in vivo methods of using such compositions to promote bone and soft tissue growth and healing.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A composition comprising:
 a) a biodegradable polymer; and   b) a honey.   
     
     
         2 . A membrane comprising:
 a) a biodegradable polymer; and   b) a honey.   
     
     
         3 . The membrane of  claim 2 , further comprising a filler. 
     
     
         4 . A multiple-layer membrane comprising at least two layers of the membrane of  claim 2 . 
     
     
         5 . The multiple-layer membrane of  claim 4 , wherein the multiple-layer membrane comprises 2-4 layers of the membrane of  claim 2 . 
     
     
         6 . The multiple-layer membrane of  claim 4 , wherein the multiple-layer membrane comprises four layers of the membrane of  claim 2 . 
     
     
         7 . The multiple-layer membrane of  claim 4 , wherein the at least two layers are crosslinked. 
     
     
         8 . The multiple-layer membrane of  claim 7 , wherein the at least two layers are crosslinked with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, genipin, or glutaraldehyde. 
     
     
         9 - 12 . (canceled) 
     
     
         13 . A method of making a fiber of claim  12 , the method comprising:
 a) dispersing the filler in a solvent to form a dispersion;   b) combining the biodegradable polymer and honey with the dispersion to form a composition; and   c) electrospinning the composition to form the fiber of claim  12 .   
     
     
         14 . A method of making a membrane of  claim 3 , the method comprising:
 a) dispersing the filler in a solvent to form a dispersion;   b) combining the biodegradable polymer and honey with the dispersion to form a composition; and   c) electrospinning the composition to form fibers, thereby forming the membrane of  claim 3 .   
     
     
         15 . A method of making a membrane of  claim 3 , the method comprising:
 a) dispersing the filler in a solvent to form a dispersion;   b) combining the biodegradable polymer and honey with the dispersion;   c) removing solvent from the dispersion to form a sponge; and   d) compressing the sponge to form the membrane of  claim 3 .   
     
     
         16 - 18 . (canceled) 
     
     
         19 . A method of promoting bone regeneration, the method comprising contacting a bone surface with the composition of  claim 1 , or the fiber of claim  11 , or the membrane of  claim 2 . 
     
     
         20 . A method of promoting healing of a bone defect, the method comprising contacting the bone defect with the membrane of  claim 2 . 
     
     
         21 - 23 . (canceled)

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