Fast-eluting three-dimensionally molded object, filament for fast-eluting three-dimensionally molded object, and material for fast-eluting three-dimensionally molded object

Abstract

Provided is a fast-eluting three-dimensionally molded object, which is formed by fused deposition modeling type three-dimensional molding and quickly elutes an active component. The fast-eluting three-dimensionally molded object is formed by the fused deposition modeling type three-dimensional molding and includes an active component, a water-soluble thermoplastic polymer, a water-soluble sugar and/or a water-soluble sugar alcohol, and a plasticizer component. The fast-eluting three-dimensionally molded object has an elution rate of the active component of 80% or higher within 85 minutes by a dissolution test method in the Japanese Pharmacopoeia, Sixteenth Edition.

1 . A fast-eluting three-dimensionally molded object formed by fused deposition modeling type three-dimensional molding, comprising:
 an active component;   a water-soluble thermoplastic polymer;   a water-soluble sugar and/or a water-soluble sugar alcohol; and   a plasticizer component.   
     
     
         2 . The fast-eluting three-dimensionally molded object according to  claim 1 , wherein an elution rate of the active component by a paddle method of a dissolution test method in the Japanese Pharmacopoeia, Sixteenth Edition, is 80% or higher within 85 minutes. 
     
     
         3 . The fast-eluting three-dimensionally molded object according to  claim 1 , wherein the water-soluble sugar and/or the water-soluble sugar alcohol has a glass transition temperature of a room temperature or higher. 
     
     
         4 . The fast-eluting three-dimensionally molded object according to  claim 1 , wherein the water-soluble sugar and/or the water-soluble sugar alcohol is one or more kinds selected from a group consisting of sucrose, maltitol, xylitol, mannitol, erythritol, sorbitol, isomalt, and lactitol. 
     
     
         5 . The fast-eluting three-dimensionally molded object according to  claim 1 , wherein the water-soluble sugar and/or the water-soluble sugar alcohol is one or more kinds selected from a group consisting of maltitol, xylitol, mannitol, erythritol, sorbitol, isomalt, and lactitol. 
     
     
         6 . The fast-eluting three-dimensionally molded object according to  claim 1 , wherein the water-soluble thermoplastic polymer is one or more kinds selected from a group consisting of a polyvinyl alcohol, a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, polyethylene oxide, polyvinylpyrrolidone, copolyvidone, a polyethylene glycol-polyvinyl alcohol-graft copolymer, a polyvinyl alcohol-acrylic acid-methyl methacrylate copolymer, aminoalkyl methacrylate copolymer RS, and aminoalkyl methacrylate copolymer E. 
     
     
         7 . The fast-eluting three-dimensionally molded object according to  claim 1 , wherein the water-soluble thermoplastic polymer is one or more kinds selected from a group consisting of a polyvinyl alcohol, polyvinylpyrrolidone, and aminoalkyl methacrylate copolymer E. 
     
     
         8 . The fast-eluting three-dimensionally molded object according to  claim 1 , wherein:
 the water-soluble thermoplastic polymer is one or more kinds selected from a group consisting of a polyvinyl alcohol, polyvinylpyrrolidone, and aminoalkyl methacrylate copolymer E; and   the water-soluble sugar and/or the water-soluble sugar alcohol is maltitol.   
     
     
         9 . The fast-eluting three-dimensionally molded object according to  claim 1 , wherein a content of the water-soluble sugar and/or the water-soluble sugar alcohol is 10 to 65 wt. % with respect to a total weight of the three-dimensionally molded object. 
     
     
         10 . The fast-eluting three-dimensionally molded object according to  claim 1 , wherein a content of the water-soluble thermoplastic polymer is 20 to 90 wt. % with respect to the total weight of the three-dimensionally molded object. 
     
     
         11 . The fast-eluting three-dimensionally molded object according to  claim 1 , wherein the elution rate of the active component is 80% or higher within 30 minutes. 
     
     
         12 . The fast-eluting three-dimensionally molded object according to  claim 1 , wherein the fast-eluting three-dimensionally molded object is a ring-shaped solid object. 
     
     
         13 . A filament for fast-eluting three-dimensionally molded object used for forming a three-dimensionally molded object by fused deposition modeling type three-dimensional molding, comprising:
 an active component;   a water-soluble thermoplastic polymer;   a water-soluble sugar and/or a water-soluble sugar alcohol; and   a plasticizer component.   
     
     
         14 . A material for fast-eluting three-dimensionally molded object used for forming a three-dimensionally molded object by fused deposition modeling type three-dimensional molding, comprising:
 an active component;   a water-soluble thermoplastic polymer;   a water-soluble sugar and/or a water-soluble sugar alcohol; and   a plasticizer component.