Magnetic beads and the manufacturing method thereof

Abstract

Described herein is a magnetic particle, which includes a knobby copolymer core, a polymer layer, a magnetic substance layer and a silicon-based layer. The polymer layer covers the knobby copolymer core and has at least one functional group. In addition, the magnetic substance layer covers the polymer layer and the silicon-based layer covers the magnetic substance layer. Furthermore, a manufacturing method of the magnetic particle is also described.

What is claimed is: 
     
         1 . A magnetic particle, comprising:
 a knobby copolymer core;   a polymer layer, covering the knobby copolymer core and having at least one functional group;   a magnetic substance layer, covering the polymer layer; and   a silicon-based layer, covering the magnetic substance layer.   
     
     
         2 . The magnetic particle of  claim 1 , wherein an average diameter of the magnetic particle is 1 μm to 50 μm. 
     
     
         3 . The magnetic particle of  claim 1 , wherein the knobby copolymer core comprises a plurality of protrusions and an average height of the plurality of protrusions is 100 nm to 5000 nm. 
     
     
         4 . The magnetic particle of  claim 1 , wherein the knobby copolymer core comprises a copolymer obtained by copolymerizing a monofunctional monomer and a bifunctional monomer. 
     
     
         5 . The magnetic particle of  claim 4 , wherein a volume percentage of the bifunctional monomer relative to the monofunctional monomer is 0.4% to 2%. 
     
     
         6 . The magnetic particle of  claim 1 , wherein the knobby copolymer core comprises a styrene/divinylbenzene copolymer, a methyl methacrylate/triethylene glycol dimethacrylate copolymer, a methyl methacrylate/ethylene glycol dimethacrylate copolymer, a styrene/triethylene glycol dimethacrylate copolymer, a styrene/ethylene glycol dimethacrylate copolymer, or a methyl methacrylate/divinylbenzene copolymer. 
     
     
         7 . The magnetic particle of  claim 1 , wherein the at least one functional group is charged. 
     
     
         8 . The magnetic particle of  claim 1 , wherein the at least one functional group comprises a carboxyl group, an amine group, or a combination thereof. 
     
     
         9 . The magnetic particle of  claim 1 , wherein the magnetic substance layer comprises a paramagnetic substance, a superparamagnetic substance, a ferromagnetic substance, a ferrite magnetic substance, or a combination thereof. 
     
     
         10 . The magnetic particle of  claim 1 , wherein the magnetic substance layer comprises an iron ion (Fe 2+ ), a cobalt ion (Co 2+ ), a nickel ion (Ni 2+ ), or a combination thereof. 
     
     
         11 . The magnetic particle of  claim 1 , wherein a thickness of the magnetic substance layer is 20 nm to 200 nm. 
     
     
         12 . The magnetic particle of  claim 1 , wherein the silicon-based layer comprises siloxane, silica glass, silicon oxide, silicate salt or a combination thereof. 
     
     
         13 . The magnetic particle of  claim 1 , wherein a thickness of the silicon-based layer is at least 1 nm to 50 nm. 
     
     
         14 . A manufacturing method of a magnetic particle, comprising:
 polymerizing at least two monomers into a copolymer to form a knobby copolymer core;   forming a polymer layer to cover the knobby copolymer core, wherein the polymer layer has at least one functional group;   adsorbing a magnetic substance precursor by the knobby copolymer core covered with the polymer layer to form a magnetic substance layer; and   forming a silicon-based layer to cover the magnetic substance layer.   
     
     
         15 . The manufacturing method of the magnetic particle of  claim 14 , wherein the at least two monomers comprise monofunctional monomer and bifunctional monomer. 
     
     
         16 . The manufacturing method of the magnetic particle of  claim 15 , wherein a volume percentage of the bifunctional monomer relative to the monofunctional monomer is 0.4% to 2%. 
     
     
         17 . The manufacturing method of the magnetic particle of  claim 15 , wherein the copolymer core comprises a styrene/divinylbenzene copolymer, a methyl methacrylate/triethylene glycol dimethacrylate copolymer, a methyl methacrylate/ethylene glycol dimethacrylate copolymer, a styrene/triethylene glycol dimethacrylate copolymer, a styrene/ethylene glycol dimethacrylate copolymer, or a methyl methacrylate/divinylbenzene copolymer. 
     
     
         18 . The manufacturing method of the magnetic particle of  claim 14 , wherein the at least one functional group comprises a carboxyl group, an amine group, or a combination thereof. 
     
     
         19 . The manufacturing method of the magnetic particle of  claim 14 , wherein the magnetic substance layer comprises an iron ion (Fe 2+ ), a cobalt ion (Co 2+ ), a nickel ion (Ni 2+ ), or a combination thereof. 
     
     
         20 . The manufacturing method of the magnetic particle of  claim 14 , wherein the silicon-based layer comprises siloxane, silica glass, silicon oxide, silicate salt or a combination thereof.