System and method for mounting a specimen on a slide

Abstract

A system and method for mounting a section onto a substrate, the system comprising: a fluid channel including: a fluid channel inlet that receives the section, processed from a bulk embedded sample by a sample sectioning module positioned proximal the fluid channel inlet, a section-mounting region downstream of the fluid channel inlet, and a fluid channel outlet downstream of the section-mounting region; a reservoir in fluid communication with the fluid channel outlet; and a manifold, fluidly coupled to the reservoir, that delivers fluid from the reservoir to the fluid channel inlet, thereby recirculating fluid flow between the fluid channel inlet and the fluid channel outlet to carry sections between the sample sectioning module and the section mounting region.

1 . A system for mounting a section onto a substrate, the system comprising:
 a fluid channel comprising:
 a fluid channel inlet that receives the section, processed from a bulk embedded sample by a sample sectioning module positioned proximal the fluid channel inlet; 
   a manifold, fluidly coupled to the fluid channel, comprising:
 a fluid injector that directs a constant fluid flow at an angle relative to a base surface of the fluid channel inlet, thereby providing a force that separates the section from the sample sectioning module, and 
 a pump, wherein the pump delivers fluid to the fluid channel inlet at the fluid injector, thereby transmitting fluid flow that drives delivery of the section from the fluid channel inlet along the fluid channel; and 
   a controller, communicatively coupled to the fluid injector, operable to pulse the fluid flow from the fluid injector at:
 a first predetermined frequency temporally synchronized with a sectioning frequency of the sample sectioning module, wherein the fluid flow assists with motion of the section away from the sample sectioning module subsequent to separation.