Dry-powder inhalation device

Abstract

An improved dry-powder inhalation device having a casing having an air inlet located at a first terminus; a powder delivery port located at a second terminus, which is positioned distal to the air inlet; and an elongated support panel located within an interior of the casing and being fitted within the casing so as to partially rotate therein about a single axis. The casing has at least one compartment containing dry-powder located proximally to the second terminus, and the support panel has a plurality of needle-like structures located proximal to the delivery port and arranged opposite the dry-powder compartment. The compartment with a dry-powder includes a cover encasing the dry-powder, whereby airflow through the device causes the elongated support panel to partially rotate repeatedly within the casing, whereby the plurality of needle-like structures strike the covered compartment, causing the dry-powder to be released into the airflow.

1 . An inhaler device comprising:
 a casing having a first terminus and a second terminus, the casing further having at least one compartment containing an inhalable medicament located proximal to the second terminus of the casing and hermetically sealed by a cover that is configured to be punctured;   an air inlet located proximal to the first terminus of the casing;   a delivery port located proximal to the second terminus of the casing and positioned distal to the air inlet; and   an elongated support panel comprising a first terminus and a second terminus at opposite ends thereof and having at least one pin structure protruding therefrom;   the support panel being rotatably mounted within an interior of the casing such that the support panel partially rotates within the casing about a single axis upon flowing of air through the casing from the air inlet to the delivery port upon inhalation by a user at the second terminus of the casing;   wherein inhalation by the user of air through the casing causes the partial rotation of the elongated support panel within the casing, causing the at least one pin structure to strike the at least one compartment, such that the at least one pin structure punctures the hermetically sealed cover and allows the medicament contained within the at least one compartment to become released into the air flowing through the device.   
     
     
         2 . The inhaler device according to  claim 1 , wherein the compartment cover is made of aluminum or aluminum foil. 
     
     
         3 . The inhaler device according to  claim 1 , wherein the casing, the elongated support panel, or a combination thereof is rectangular. 
     
     
         4 . The inhaler device according to  claim 1 , wherein the casing comprises at least two compartments containing an inhalable medicament. 
     
     
         5 . The inhaler device according to  claim 4 , wherein the two or more compartments each houses a different inhalable medicament. 
     
     
         6 . The inhaler device according to  claim 1 , wherein the compartment containing the inhalable medicament comprises at least one partition, creating at least two separate chambers in the compartment. 
     
     
         7 . The inhaler device according to  claim 6 , wherein each of the at least two separate chambers houses a different inhalable medicament. 
     
     
         8 . The inhaler device according to  claim 1 , wherein the inhalable medicament is a therapeutic agent in the form of a dry-powder. 
     
     
         9 . The inhaler device according to  claim 8 , wherein the therapeutic agent is a drug or a vaccine. 
     
     
         10 . The inhaler device according to  claim 1 , wherein the casing comprises at least one compartment on an upper internal surface thereof proximal to the second terminus of the casing and at least one compartment on a lower internal surface thereof proximal to the second terminus of the casing. 
     
     
         11 . The inhaler device according to  claim 10 , wherein the elongated support panel has at least one pin structure protruding from an upper surface thereof and at least one pin structure protruding from a lower surface thereof. 
     
     
         12 . A kit comprising at least one inhaler device according to  claim 1 . 
     
     
         13 . An inhaler device comprising:
 a casing having an air inlet and a powder delivery port located opposite the air inlet, and further having at least one compartment on an internal surface thereof containing a dry-powder medicament and being hermetically sealed by a cover; and   an elongated support panel located within an interior of the casing and having at least one at least one pin structure thereon protruding therefrom;   wherein the elongated support panel is configured to partially rotate about a single axis within the casing upon inhalation by a user on the casing, resulting in air flowing through the device, the partial rotation causing the at least one pin structure protruding therefrom to strike the at least one compartment, thereby puncturing the hermetically sealed cover of the compartment and releasing the dry-powder into the air flowing through the device.   
     
     
         14 . The inhaler device according to  claim 13 , wherein the casing comprises at least one compartment on an upper internal surface thereof and at least one compartment on a lower internal surface thereof. 
     
     
         15 . The inhaler device according to  claim 14 , wherein the elongated support panel has at least one pin structure protruding from an upper surface thereof and at least one pin structure protruding from a lower surface thereof. 
     
     
         16 . A method of administering an inhalable therapeutic agent to a subject, said method comprising:
 providing a therapeutic agent inhaler device comprising:
 a casing having an air inlet and a delivery port located opposite the air inlet, the casing comprising at least one compartment containing the therapeutic agent and being hermetically sealed by a cover; and 
 an elongated support panel located within an interior of the casing and having at least one pin structure protruding therefrom; 
   wherein inhalation by a user of air through the casing causes the elongated support panel to partially rotate about a single axis within the casing, causing the at least one pin structure to strike against the at least one compartment, thereby puncturing the hermetically sealed cover of the compartment and releasing the therapeutic agent into the air flowing through the casing.