US2019177358A1PendingUtilityA1

Compositions and methods for treating cns disorders

Assignee: SAGE THERAPEUTICS INCPriority: Oct 16, 2014Filed: Nov 30, 2018Published: Jun 13, 2019
Est. expiryOct 16, 2034(~8.2 yrs left)· nominal 20-yr term from priority
A61P 25/18A61P 25/14A61P 25/28A61P 25/08A61P 25/20A61P 25/06A61P 23/00A61P 25/00A61K 31/57C07J 31/006C07J 11/00C07J 43/003C07J 71/001C07J 51/00C07J 21/00C07J 7/007C07J 13/007A61K 45/06A61K 31/58C07J 1/0011C07J 5/0053C07J 3/005C07J 7/008A61K 31/575C07J 41/0066C07J 1/0022C07J 9/00C07J 7/002C07J 7/00
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Claims

Abstract

or a pharmaceutically acceptable salt thereof; wherein , A, R1, R2, R3a, R4a, R4b, R5, R7a, and R7b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

Claims

exact text as granted — not AI-modified
1 - 73 . (canceled) 
     
     
         74 . A compound of the formula: 
       
         
           
           
               
               
           
         
       
     
     
         75 . A pharmaceutical composition comprising the compound of  claim 74  and a pharmaceutically acceptable excipient. 
     
     
         76 . A compound of formula: 
       
         
           
           
               
               
           
         
       
     
     
         77 . A pharmaceutical composition comprising the compound of  claim 76  and a pharmaceutically acceptable excipient. 
     
     
         78 . A compound of formula: 
       
         
           
           
               
               
           
         
       
     
     
         79 . A pharmaceutical composition comprising the compound of  claim 78  and a pharmaceutically acceptable excipient. 
     
     
         80 . A pharmaceutically acceptable salt of the compound according to  claim 74 ,  76 , or  78 . 
     
     
         81 . A pharmaceutical composition comprising a pharmaceutically acceptable salt according to  claim 80  and a pharmaceutically acceptable excipient.

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