All natural, non-toxic sublingual drug delivery systems

Abstract

Methods for producing all natural non-toxic sublingual delivery systems that have improved absorption and onset profiles for active compounds, along with improved bioavailability and pharmacokinetics compared to tablets for oral administration.

1 . A method for producing a quick-dissolve sublingual tablet, comprising:
 formulating a mixture comprising a flavoring agent, sodium bicarbonate, citric acid, and a pharmaceutically active component in powder form; and   compressing the mixture to form sublingual tablets that dissolve in less than 30 seconds upon sublingual administration.   
     
     
         2 . The method of  claim 1 , wherein the sublingual tablets are round convex or round concave tablets. 
     
     
         3 . The method of  claim 1 , wherein the sublingual tablet has a concavity that enables pooled saliva to speed dissolution upon sublingual administration. 
     
     
         4 . The method of  claim 1 , wherein the sublingual tablets further comprise magnesium stearate, and microcrystalline cellulose. 
     
     
         5 . The method of  claim 1 , wherein the sublingual tablets further comprise croscarmellose. 
     
     
         6 . The method of  claim 1 , wherein the sublingual tablets further comprise microcrystalline cellulose. 
     
     
         7 . The method of  claim 1 , wherein the sublingual tablets further comprise sucralose. 
     
     
         8 . The method of  claim 1 , wherein the pharmaceutically active component comprises sildenafil or a sildenafil-analogue. 
     
     
         9 . The method of  claim 1 , wherein the pharmaceutically active component comprises sildenafil citrate. 
     
     
         10 . The method of  claim 1 , wherein the pharmaceutically active component is a statin. 
     
     
         11 . The method of  claim 1 , wherein the sublingual tablets further comprise a vegetable oil. 
     
     
         12 . The method of  claim 1 , wherein the sublingual tablets are formulated for rapid onset of action beginning within 5 minutes of sublingual administration. 
     
     
         13 . The method of  claim 1 , wherein the compression methods provide for controlled release of the pharmaceutically active component. 
     
     
         14 . The method of  claim 1 , wherein the sublingual tablets are formulated for rapid onset of action beginning within 5 minutes of sublingual administration, and peaking between 15 and 30 minutes after administration.