Left atrial appendage occluder device

Abstract

The present disclosure describes a device that can be implanted into the left atrial appendage for occlusion. The device can prevent or reduce thrombus formation in this anatomic region for patients with atrial fibrillation. This device includes a patient-specific inflatable device that represents a patient's anatomy or morphological class. The inflatable device can be designed by imaging (e.g., computed tomography, magnetic resonance imaging) the patient's anatomy. Through a catheter (or surgically), the inflatable device can be filled with an inflation fluid to occlude the appendage in a patient-specific fashion.

What is claimed: 
     
         1 . An implantable, morphology-specific occluder device comprising:
 an inflatable implant comprising at least one lobe, wherein a volumetric shape of the inflatable implant in an inflated state is configured to match a left atrial appendage (LAA) morphology class;   a valve configured to enable a lumen to pass into an interior volume of the inflatable implant in a first direction and substantially prevent an inflation fluid from flowing in a second direction opposite the first direction; and   the inflation fluid configured to fill the interior volume of the inflatable implant to expand the inflatable implant from a deflated state to the inflated state.   
     
     
         2 . The device of  claim 1 , wherein the valve further comprises one of a polymeric and a metal septum configured to seal a location pierced by the lumen. 
     
     
         3 . The device of  claim 1 , wherein the inflation fluid is a curable fluid. 
     
     
         4 . The device of  claim 3 , wherein the inflation fluid is configured to cure upon an exposure to one of an ultraviolet energy and a thermal energy. 
     
     
         5 . The device of  claim 1 , wherein the inflation fluid comprises at least one of an epoxy, polyethylene glycol, a collagen-based polymeric gel, saline, a contrast material, and a self-expanding foam. 
     
     
         6 . The device of  claim 1 , wherein the LAA morphology class is one of a chicken wing class, a cactus class, windsock class, and a cauliflower class. 
     
     
         7 . The device of  claim 1 , wherein the LAA morphology class is a patient-specific morphology class based on at least one of a computed tomography image, an ultrasound image, and a magnetic resonance image of the patient's anatomy. 
     
     
         8 . The device of  claim 1 , wherein the inflatable implant comprises a first lobe having a first volumetric shape and the second lobe having a second volumetric shape that is different than the first volumetric shape. 
     
     
         9 . The device of  claim 1 , wherein the inflatable implant comprising a third lobe. 
     
     
         10 . The device of  claim 1 , wherein the inflatable implant comprises a first lobe having a first axis and the second lobe having a second axis askew from the first axis. 
     
     
         11 . A method to occlude an atrial appendage, comprising:
 deploying an inflatable implant into a left atrial appendage (LAA), the inflatable implant comprising:
 at least one lobe, wherein a volumetric shape of the inflatable implant in an inflated state is configured to match a LAA morphology class; 
 a valve configured to enable a lumen to pass into an interior volume of the inflatable implant in a first direction and substantially prevent an inflation fluid from flowing in a second direction opposite the first direction; 
   filling the inflatable implant with the inflation fluid, wherein the inflation fluid is configured to fill the interior volume of the inflatable implant to expand the inflatable implant from a deflated state to the inflated state; and   anchoring the inflatable implant to a wall of the LAA.   
     
     
         12 . The method of  claim 11 , further comprising removing the lumen from the valve, wherein the valve further comprises at least one of a polymeric septum and a metal septum configured to seal a location pierced by the lumen. 
     
     
         13 . The method of  claim 11 , further comprising curing the inflation fluid. 
     
     
         14 . The method of  claim 13 , further comprising exposing the inflation fluid to at least one of an ultraviolet energy and a thermal energy. 
     
     
         15 . The method of  claim 11 , wherein the inflation fluid comprises at least one of an epoxy, polyethylene glycol, a collagen-based polymeric gel, saline, a contrast material, and a self-expanding foam. 
     
     
         16 . The method of  claim 11 , wherein LAA morphology class is one of a chicken wing class, a cactus class, windsock class, and a cauliflower class. 
     
     
         17 . The method of  claim 11 , wherein the LAA morphology class is a patient-specific morphology class based on at least one of a computed tomography image, an ultrasound image, and a magnetic resonance image of the patient's anatomy. 
     
     
         18 . The method of  claim 11 , wherein the inflatable implant comprises a first lobe having a first volumetric shape and the second lobe having a second volumetric shape that is different than the first volumetric shape. 
     
     
         19 . The method of  claim 11 , wherein the inflatable implant comprises a third lobe. 
     
     
         20 . The method of  claim 11 , wherein the inflatable implant comprises a first lobe having a first axis and a second lobe having a second axis askew from the first axis.