Sensitivity Calibration of In Vivo Sensors Used to Measure Analyte Concentration

Abstract

Methods, devices, systems, and computer program products are provided to improve sensitivity calibration of an in vivo analyte sensor and usability of an associated analyte monitoring system. In certain embodiments, methods are provided that improve the user experience of using an analyte monitoring system. Certain embodiments of the present disclosure include features that reduce the amount of calibration or re-calibration performed by the analyte monitoring system. More specifically methods of using a suspect calibration attempt to avoid having to recalibrate by adjusting the calibration or mitigating effects of sensor signal attenuation that caused the calibration attempt to be suspect are provided. Additional features are disclosed.

What is claimed is: 
     
         1 . A method, comprising:
 determining a lot sensitivity for a plurality of sensors of a manufacturing lot;   determining one or more sensor-specific correction factors for a selected analyte sensor of the plurality of sensors of the manufacturing lot based on the lot sensitivity; and   storing the one or more sensor-specific correction factors in a memory of a sensor electronics for the selected analyte sensor.   
     
     
         2 . The method of  claim 1 , wherein the lot sensitivity includes one of a median sensitivity or a mean sensitivity. 
     
     
         3 . The method of  claim 1 , further comprising determining a sensitivity for the selected analyte sensor using the one or more sensor-specific correction factors and the lot sensitivity. 
     
     
         4 . The method of  claim 1 , wherein the one or more sensor-specific correction factors are based on an aggregate plurality of prior sensor uses. 
     
     
         5 . The method of  claim 4 , wherein the aggregate plurality of prior sensor uses are uses of the plurality of analyte sensors of the manufacturing lot. 
     
     
         6 . The method of  claim 1 , wherein the one or more sensor-specific correction factors are determined based on one or more characteristics of the selected analyte sensor. 
     
     
         7 . The method of  claim 1 , wherein the selected analyte sensor is one of a glucose sensor or a lactate sensor. 
     
     
         8 . The method of  claim 1 , wherein storing the one or more sensor-specific correction factors comprises storing the one or more sensor-specific correction factors in a table. 
     
     
         9 . The method of  claim 1 , further comprising updating the one or more sensor-specific correction factors in the memory of the sensor electronics. 
     
     
         10 . The method of  claim 1 , further comprising updating the one or more sensor-specific correction factors in the memory of the sensor electronics in real time. 
     
     
         11 . A device, comprising:
 one or more processors; and   a memory storing instructions which, when executed by the one or more processors, cause the one or more processors to:
 determine a lot sensitivity for a plurality of sensors of a manufacturing lot; 
 determine one or more sensor-specific correction factors for a selected analyte sensor of the plurality of sensors of the manufacturing lot based on the lot sensitivity; and 
 store the one or more sensor-specific correction factors in a memory of a sensor electronics for the selected analyte sensor. 
   
     
     
         12 . The device of  claim 11 , wherein the lot sensitivity includes one of a median sensitivity or a mean sensitivity. 
     
     
         13 . The device of  claim 11 , the memory storing instructions which, when executed by the one or more processors, cause the one or more processors to determine a sensitivity for the selected analyte sensor using the one or more sensor-specific correction factors and the lot sensitivity. 
     
     
         14 . The device of  claim 11 , wherein the one or more sensor-specific correction factors are based on an aggregate plurality of prior sensor uses. 
     
     
         15 . The device of  claim 14 , wherein the aggregate plurality of prior sensor uses are uses of the analyte sensors of the manufacturing lot. 
     
     
         16 . The device of  claim 11 , wherein the one or more sensor-specific correction factors are determined based on one or more characteristics of the selected analyte sensor. 
     
     
         17 . The device of  claim 11 , wherein the selected analyte sensor is one of a glucose sensor or a lactate sensor. 
     
     
         18 . The device of  claim 11 , the memory storing instructions which, when executed by the one or more processors, cause the one or more processors to store the one or more sensor-specific correction factors by at least storing the one or more sensor-specific correction factors in a table. 
     
     
         19 . The device of  claim 11 , the memory storing instructions which, when executed by the one or more processors, cause the one or more processors to update the one or more sensor-specific correction factors in the memory of the sensor electronics. 
     
     
         20 . The device of  claim 11 , the memory storing instructions which, when executed by the one or more processors, cause the one or more processors to update the one or more sensor-specific correction factors in the memory of the sensor electronics in real time.