Antioxidant composition comprising sargassum serratifolium extract or fraction thereof as active ingredient

Abstract

The present invention relates to an antioxidant composition and, more specifically, to an antioxidant composition including a Sargassum serratifolium extract or a fraction thereof as an active ingredient, in which the antioxidant composition is a useful material (substance) that can be added to medicines, cosmetics, foods, animal feeds, and the like. The present invention also relates to a pharmaceutical composition for preventing or treating eye diseases, a food composition for alleviating eye diseases, and a health functional food, each of which includes a Sargassum serratifolium extract or a compound separated therefrom as an active ingredient.

1 . A composition having an antioxidative activity, the composition comprising a  Sargassum serratifolium  extract or a fraction thereof as an active ingredient. 
     
     
         2 . The composition of  claim 1 , wherein the extract is extracted with at least one solvent selected from the group consisting of lower alcohols having 1 to 4 carbon atoms, ethyl acetate, acetone, water, and hexane. 
     
     
         3 . The composition of  claim 2 , wherein the lower alcohols having 1 to 4 carbon atoms include ethanol. 
     
     
         4 . The composition of  claim 1 , wherein the fraction is a hexane fraction of the  Sargassum serratifolium  extract. 
     
     
         5 . The composition of  claim 1 , comprising the  Sargassum serratifolium  extract or the fraction thereof in a concentration of 0.1 μg/ml to 1000 μg/ml. 
     
     
         6 . The composition of  claim 1 , wherein the composition is a pharmaceutical composition, a cosmetic composition, a food composition, or a feed composition. 
     
     
         7 . A method of treating skin from aging effects of reactive oxygen species (ROS) on a subject comprising topically administering the composition of  claim 1  to the subject in need thereof. 
     
     
         8 . The method of  claim 7 , wherein the extract is extracted with an ethanol solvent. 
     
     
         9 . The method of  claim 7 , wherein the fraction is a hexane fraction of the  Sargassum serratifolium  extract. 
     
     
         10 . The method of  claim 7 , wherein the composition is a cosmetic composition having a formulation selected from the group consisting of a toner, a gel, soluble liquid, a milky lotion, a nutrition cream, a massage cream, an essence, an oil-in-water type emulsion, a water-in-oil type emulsion, a paste-like anhydrous product, a solid anhydrous product, an oil dispersion in aqueous phase using small spheres, an ionic lipid vesicle, a nonionic lipid vesicle, ointment, cleansing foam, cleansing water, pack, body oil, oil-in-water type makeup base, water-in-oil type makeup base, foundation, skin cover, lipstick, lip gloss, face powder, twin cake, eyeshadow, mascara, cheek color, and eyebrow pencil. 
     
     
         11 . A method of treating eye disease, comprising administering to a person in need thereof, a pharmaceutical composition comprising a  Sargassum serratifolium  extract or a compound separated therefrom as an active ingredient. 
     
     
         12 . The pharmaceutical composition of  claim 11 , wherein the extract is extracted with an ethanol solvent. 
     
     
         13 . The pharmaceutical composition of  claim 11 , wherein the compound is sargahydroquinoic acid, sargaquinoic acid, or sagachromenol. 
     
     
         14 . The pharmaceutical composition of  claim 11 , wherein the eye disease is one selected from the group consisting of age-related macular degeneration, glaucoma, diabetic retinopathy, retinitis pigmentosa, choroidal neovascular membrane, uveitis, myopic degeneration, ocular tumor, central retinal vein occlusion, skin flushing, ocular neovascularization, central serous retinopathy, dry eye syndrome, central retinal artery occlusion, and cystoid macular edema. 
     
     
         15 . The method of  claim 11 , wherein the composition is a food composition. 
     
     
         16 . The method of  claim 15 , wherein the extract is the  Sargassum serratifolium  ethanol extract, and
 wherein the compound is sargahydroquinoic acid, sargaquinoic acid, or sagachromenol.   
     
     
         17 . A health functional food for preventing or alleviating an eye disease, the health functional food comprising a  Sargassum serratifolium  extract or a compound separated therefrom as an active ingredient. 
     
     
         18 . The health functional food of  claim 17 , wherein the extract is the  Sargassum serratifolium  ethanol extract, and
 wherein the compound is sargahydroquinoic acid, sargaquinoic acid, or sagachromenol.   
     
     
         19 . The health functional food of  claim 17 , wherein the food is one selected from the group consisting of a beverage, meat, chocolate, a food, snack, pizza, ramen, another noodle, a gum, candy, ice cream, an alcoholic beverage, a vitamin complex, and a health supplement food. 
     
     
         20 . The health functional food of  claim 17 , wherein the  Sargassum serratifolium  extract or the compound separated therefrom has an effect of protecting a photoreceptor cell by antioxidative activity.