Sustained-release preparation composition for animals

Abstract

The present invention relates to a sustained-release pharmaceutical composition intended for animal use, which comprises a drug, a sugar, a wax, and a water-soluble polymer.

1 - 10 . (canceled) 
     
     
         11 . A sustained-release composition intended for animal use, comprising (i) zonisamide, (ii) a sugar, (iii) a wax, and (iv) a water-soluble polymer, wherein
 (i) the content of zonisamide is 10 wt %-90 wt %,   (ii) the sugar is one or more selected from isomalt, mannitol, lactose, sucrose, glucose, and sorbitol, and the content of the sugar is 5 wt %-90 wt %,   (iii) the wax is one or more selected from hydrogenated castor oil, hydrogenated rapeseed oil, carnauba wax, stearic acid, and sodium stearyl fumarate, and the content of the wax is 0.5 wt %-70 wt %,   (iv) the water-soluble polymer is one or more selected from gum arabic, xanthane gum, hydroxypropylcellulose (HPC), hydroxypropylmethylcellulose (HPMC), and methylcellulose (MC), the content of the water-soluble polymer is 2 wt %-80 wt %, and   the animal belongs to Carnivora.   
     
     
         12 . The sustained-release composition of  claim 11 , wherein (i) the content of the zonisamide is 15 wt %-80 wt %, (ii) the content of the sugar is 10 wt %-80 wt %, (iii) the content of the wax is 1 wt %-60 wt %, and (iv) the content of the water-soluble polymer is 4 wt %-70 wt %. 
     
     
         13 . The sustained-release composition of  claim 11 , wherein (i) the content of the zonisamide is 20 wt %-70 wt %, (ii) the content of the sugar is 15 wt %-70 wt %, (iii) the content of the wax is 1.5 wt %-50 wt %, and (iv) the content of the water-soluble polymer is 6 wt %-60 wt %. 
     
     
         14 . The sustained-release composition of  claim 11 , wherein the animal is dogs or cats. 
     
     
         15 . The sustained-release composition of  claim 11 , whose formulation is a tablet. 
     
     
         16 . The sustained-release composition of  claim 11 , wherein the sugar is isomalt. 
     
     
         17 . The sustained-release composition of  claim 11 , wherein the water-soluble polymer is gum arabic and/or hydroxypropylcellulose (HPC).