Antibacterial calcium-based materials

Abstract

A preparation at least useful as a bone implant, which contains a solid component including a lithium compound and a calcium compound. The preparation shows an anti-bacterial ability in comparison with a preparation contains the calcium compound but free of the lithium compound.

1 . A bone implant preparation, which is composed of a free-flowing powder component, and an aqueous solution free of lithium ions, said bone implant preparation consists of a calcium compound and a lithium compound, and optionally one or more components selected from the group consisting of a growth factor, a bone morphogenetic protein (BMP), living cells, a drug, and a poly(acrylic acid), wherein the free-flowing powder component is to be mixed with the aqueous solution at a ratio of aqueous solution to powder of 0.20 ml/g to 0.80 ml/g to form a bone cement paste, which will then set hard to form a bone implant, when the poly(acrylic acid) is present, it is present in the amount of 0.01-5% of the poly(acrylic acid), based on the total weight of the bone implant,
 wherein the lithium compound is not lithium halide,   wherein the calcium compound is selected from the group consisting of calcium phosphate, calcium sulfate, calcium oxide, calcium carbonate, calcium hydroxide, calcium magnesium phosphate, calcium nitrate, calcium citrate, calcium chloride and a mixture thereof.   
     
     
         2 . The bone implant preparation of  claim 1 , wherein the lithium compound is present in an amount of 5-80%, based on the weight of the bone implant. 
     
     
         3 . The bone implant preparation of  claim 1 , wherein the lithium compound is a lithium salt, lithium oxide, lithium amide (LiNH 2 ), or lithium hydroxide. 
     
     
         4 . The bone implant preparation of  claim 1 , wherein the lithium compound is lithium carbonate, lithium sulfate, lithium phosphate, lithium oxide, lithium acetate, lithium hydroxide, lithium nitrate, lithium nitrite, lithium molybdate (Li 2 MoO 4 ), lithium tetraborate (Li 2 B 4 O 7 ), lithium citrate tetrahydrate (Li 3 C 6 H 5 O 7 .4H 2 O), or lithium stearate (LiC 18 H 35 O 2 ). 
     
     
         5 . The bone implant preparation of  claim 1 , wherein the lithium compound is lithium carbonate, or lithium phosphate. 
     
     
         6 . The bone implant preparation of  claim 1 , wherein the calcium compound is a calcium sulfate, a calcium phosphate source, or a mixture thereof. 
     
     
         7 . The bone implant preparation of  claim 6 , wherein the calcium phosphate is tetracalcium phosphate (TTCP), dicalcium phosphate, tricalcium phosphate, monocalcium phosphate or a mixture, and the calcium sulfate is calcium sulfate hemihydrate (CSH), calcium sulfate dehydrate (CSD), anhydrous calcium sulfate, or a mixture thereof. 
     
     
         8 . The bone implant preparation of  claim 1 , wherein poly(acrylic acid) is present in the bone implant preparation. 
     
     
         9 . The bone implant preparation of  claim 8 , wherein the poly(acrylic acid) has a repeating unit of —(CH 2 —C(COOH)H) n —, wherein n=50-50000. 
     
     
         10 . The bone implant preparation of  claim 9 , wherein n=1000-5000. 
     
     
         11 . A method for treating a subject comprising
 providing the bone implant preparation as set forth in  claim 1 ;   mixing the free-flowing powder component and the aqueous solution at a ratio of aqueous solution to powder of 0.20 ml/g to 0.80 ml/g to form a bone cement paste; and   filling a hole or cavity in a bone of said subject with said bone cement paste, which set hard in the hole or cavity in need of said treatment.