Blood state analysis apparatus, blood state analysis system, blood state analysis method, and program

Abstract

The main object of the present technology is to provide a technology capable of acquiring, in a single measurement, a plurality of pieces of information related to fibrinogen, when measuring the electrical characteristics of a blood sample. In view of the above, the present technology provides a blood state analysis apparatus including at least an analysis unit that uses data related to the temporal change in electrical characteristics to analyze information related to fibrinogen in a blood sample, in which the analysis unit uses at least two predetermined time points derived from the data related to the temporal change on a basis of a predetermined mathematical definition to calculate a parameter R, and acquires at least two pieces of information related to the fibrinogen in the blood sample.

1 . A blood state analysis apparatus, comprising: at least
 an analysis unit that uses data related to a temporal change in electrical characteristics to analyze information related to fibrinogen in a blood sample, wherein   the analysis unit uses at least two predetermined time points derived from the data related to the temporal change on a basis of a predetermined mathematical definition to calculate a parameter R, and acquires at least two pieces of information related to the fibrinogen in the blood sample.   
     
     
         2 . The blood state analysis apparatus according to  claim 1 , wherein
 the at least two predetermined time points are selected from   (i) a time point when the electrical characteristics have a maximum value or a minimum value, or a time point when a change in the electrical characteristics exceeds a predetermined threshold value,   (ii) a time point when the change in the electrical characteristics exceeds a predetermined change rate set in advance, or a time point when the change in the electrical characteristics falls below the predetermined change rate set in advance,   (iii) a time point when the change in the electrical characteristics is the maximum or a middle time point between the (i) and the (ii), and   (iv) a time point when a maximum change rate is obtained between the (i) and the (ii).   
     
     
         3 . The blood state analysis apparatus according to  claim 2 , wherein
 the analysis unit compares the at least two predetermined time points selected from the (i) to (iv) with each other on a basis of a predetermined starting point.   
     
     
         4 . The blood state analysis apparatus according to  claim 1 , wherein
 the information includes at least two pieces of information selected from information related to a total amount of fibrinogen, information related to an amount of fibrinogen involved in blood clotting, and information related to a polymerization ability of fibrinogen.   
     
     
         5 . The blood state analysis apparatus according to  claim 1 , wherein
 the electrical characteristics include a dielectric constant at a specific frequency.   
     
     
         6 . The blood state analysis apparatus according to  claim 1 , wherein
 the analysis unit further uses a derivative to calculate a parameter S, the derivative being obtained at a time point before the electrical characteristics has a maximum value or a minimum value.   
     
     
         7 . The blood state analysis apparatus according to  claim 11 , wherein
 the analysis unit further uses a blood clotting amplitude to calculate a parameter A, the blood clotting amplitude being obtained at a predetermined time point.   
     
     
         8 . A blood state analysis system, comprising: at least
 a measurement unit that measures electrical characteristics of a blood sample over time; and   an analysis unit that uses data related to a temporal change in the electrical characteristics measured by the electrical characteristics measurement apparatus to analyze information related to fibrinogen in the blood sample, wherein   the analysis unit uses at least two predetermined time points derived from the data related to the temporal change on a basis of a predetermined mathematical definition to calculate a parameter R, and acquires at least two pieces of information related to the fibrinogen in the blood sample.   
     
     
         9 . The blood state analysis system according to  claim 8 , further comprising
 a server that stores the data related to the temporal change by the electrical characteristics measurement apparatus and/or an analysis result by the blood state analysis apparatus, wherein   the server is connected to the electrical characteristics measurement apparatus and/or the blood state analysis apparatus via a network.   
     
     
         10 . A blood state analysis method, comprising: at least
 a measurement step of measuring electrical characteristics of a blood sample over time; and   an analysis step of using data related to a temporal change in the electrical characteristics acquired in the measurement step to analyze information related to fibrinogen in the blood sample, wherein   the analysis step further includes using at least two predetermined time points derived from the data related to the temporal change on a basis of a predetermined mathematical definition to calculate a parameter R, and acquiring at least two pieces of information related to the fibrinogen in the blood sample.   
     
     
         11 . The blood state analysis method according to  claim 10 , wherein
 the parameter is selected from   (i) a time point when the electrical characteristics have a maximum value or a minimum value, or a time point when a change in the electrical characteristics exceeds a predetermined threshold value,   (ii) a time point when the change in the electrical characteristics exceeds a predetermined change rate set in advance, or a time point when the change in the electrical characteristics falls below the predetermined change rate set in advance,   (iii) a time point when the change in the electrical characteristics is the maximum or a middle time point between the (i) and the (ii), and   (iv) a time point when a maximum change rate is obtained between the (i) and the (ii).   
     
     
         12 . The blood state analysis method according to  claim 11 , wherein
 the analysis step further includes comparing the at least two predetermined time points selected from the (i) to (iv) with each other on a basis of a predetermined starting point.   
     
     
         13 . The blood state analysis method according to  claim 10 , wherein
 the information includes at least two pieces of information selected from information related to a total amount of fibrinogen, information related to an amount of fibrinogen involved in blood clotting, and information related to a polymerization ability of fibrinogen.   
     
     
         14 . The blood state analysis method according to  claim 10 , wherein
 the analysis step further includes using a derivative to calculate a parameter S, the derivative being obtained at a time point before the electrical characteristics has a maximum value or a minimum value.   
     
     
         15 . The blood state analysis method according to  claim 10 , wherein
 the analysis step further includes using a blood clotting amplitude to calculate a parameter A, the blood clotting amplitude being obtained at a predetermined time point.   
     
     
         16 . A program that causes a computer to function as:
 a measurement unit that measures electrical characteristics of a blood sample over time; and   an analysis unit that uses data related to a temporal change in the electrical characteristics acquired by the measurement unit to analyze information related to fibrinogen in the blood sample, wherein   the analysis unit uses at least two predetermined time points derived from the data related to the temporal change on a basis of a predetermined mathematical definition to calculate a parameter R, and acquires at least two pieces of information related to the fibrinogen in the blood sample.