5-(n-benzyl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication

Abstract

Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.

We claim: 
     
         1 . A compound of Formula I 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof wherein: 
         R 1  is hydrogen, C 1-6 alkyl, or C 3-7 cycloalkyl; 
         R 2  is tetrahydroisoquinolinyl and is substituted with 1 R 6  substituent and also with 0-3 halo or C 1-6 alkyl substituents; 
         R 3  is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 substituents selected from cyano, halo, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, and C 1-6 haloalkoxy; 
         R 4  is C 1-6 alkyl or C 1-6 haloalkyl; 
         R 5  is C 1-6 alkyl; 
         R 6  is Ar 1 , (Ar 1 ) C 1-6 alkyl, (chromanyl)C 1-6 alkyl, cyanoC 3-7 cycloalkyl or (dihydrobenzodioxinyl) C 1-6 alkyl; and 
         Ar 1  is phenyl substituted with 0-5 substituents selected from cyano, halo, C 1-6 alkyl, C 3-7 cycloalkyl, C 1-6 haloalkyl, hydroxy, C 1-6 alkoxy, C 1-6 haloalkoxy, (hydroxy)C 1-6 alkoxy-(C 1-6 alkoxy)C 1-6 alkoxy, phenoxy, benzyloxy, carboxy, phenyl, and cyanoC 3-7 cycloalkyl.