Methods of treating cancer of the central nervous system

Abstract

A method of treating a cancer of the central nervous system in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of an agent which reduces blood glutamate levels and enhances brain to blood glutamate efflux to thereby treat the cancer of the central nervous system in the subject.

What is claimed is: 
     
         1 . A method of treating a cancer of the central nervous system in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a glutamate modifying enzyme and optionally a co-factor thereof which reduces blood glutamate levels to thereby treat the cancer of the central nervous system in the subject. 
     
     
         2 . An article-of-manufacture comprising packaging material and a pharmaceutical composition identified for treating a cancer of the central nervous system being contained within the packaging material, the pharmaceutical composition including, as an active ingredient, an agent capable of reducing blood glutamate levels and an anti cancer agent and a pharmaceutically acceptable carrier. 
     
     
         3 . The article of manufacture of  claim 2 , wherein the anti cancer agent comprises a chemotherapy. 
     
     
         4 . The method of  claim 1 , wherein the glutamate modifying enzyme comprises glutamate oxaloacetate transaminase and the co-factor thereof comprises oxaloacetate. 
     
     
         5 . The method of  claim 1 , wherein the glutamate modifying enzyme comprises pyruvate transaminase and the co-factor thereof comprises pyruvate. 
     
     
         6 . The method of  claim 1 , wherein the cancer is a glioma.