Antibodies to hgf and compositions containing

Abstract

The present invention is directed to antibodies and fragments thereof having binding specificity for HGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V H , V L and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-HGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-HGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-HGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with HGF.

1 - 342 . (canceled) 
     
     
         343 . An anti-human hepatocyte growth factor (HGF) antibody or antibody fragment wherein:
 said anti-human HGF antibody or antibody fragment contains the complementarity determining regions (CDRs) of an anti-HGF antibody selected from the group consisting of Ab1, Ab2, Ab3, Ab4, Ab5, Ab6, Ab7, Ab9, Ab10, Ab11, Ab12, Ab13, Ab14, Ab15, Ab16, Ab17, Ab18, Ab19, Ab20, Ab21, Ab23, Ab24, Ab25, Ab26, and Ab27.   
     
     
         344 . An anti-human HGF antibody or antibody fragment according to  claim 343 , wherein:
 (i) said anti-human HGF antibody contains at least one residue other than a CDR residue which has been modified, which modification does not affect HGF binding;   (ii) said anti-human HGF antibody is chimeric and contains human constant domains;   (iii) said anti-HGF antibody is a human or humanized antibody or fragment thereof;   (iv) said anti-human HGF antibody or antibody fragment contains:   (a) a variable heavy chain comprising a CDR1 sequence selected from the group consisting of SEQ ID NO: 4, SEQ ID NO: 44, SEQ ID NO: 84, SEQ ID NO: 124, SEQ ID NO: 164, SEQ ID NO: 204, SEQ ID NO: 244, SEQ ID NO: 324, SEQ ID NO: 364, SEQ ID NO: 404, SEQ ID NO: 444, SEQ ID NO: 484, SEQ ID NO: 524, SEQ ID NO: 564, SEQ ID NO: 604, SEQ ID NO: 644, SEQ ID NO: 684, SEQ ID NO: 724, SEQ ID NO: 764, SEQ ID NO: 804, SEQ ID NO: 844, SEQ ID NO: 884, SEQ ID NO: 924, SEQ ID NO: 964, SEQ ID NO:1004, a CDR2 sequence selected from the group consisting of SEQ ID NO: 6, SEQ ID NO: 46, SEQ ID NO: 86, SEQ ID NO: 126, SEQ ID NO: 166, SEQ ID NO: 206, SEQ ID NO: 246, SEQ ID NO: 326, SEQ ID NO: 366, SEQ ID NO: 406, SEQ ID NO: 446, SEQ ID NO: 486, SEQ ID NO: 526, SEQ ID NO: 566, SEQ ID NO: 606, SEQ ID NO: 646, SEQ ID NO: 686, SEQ ID NO: 726, SEQ ID NO: 766, SEQ ID NO: 806, SEQ ID NO: 846, SEQ ID NO: 886, SEQ ID NO: 926, SEQ ID NO:966, and SEQ ID NO:1006; and a CDR3 sequence selected from the group consisting of SEQ ID NO: 8, SEQ ID NO: 48, SEQ ID NO: 88, SEQ ID NO: 128, SEQ ID NO: 168, SEQ ID NO: 208, SEQ ID NO: 248, SEQ ID NO: 328, SEQ ID NO: 368, SEQ ID NO: 408, SEQ ID NO: 448, SEQ ID NO: 488, SEQ ID NO: 528, SEQ ID NO: 568, SEQ ID NO: 608, SEQ ID NO: 648, SEQ ID NO: 688, SEQ ID NO: 728, SEQ ID NO: 768, SEQ ID NO: 808, SEQ ID NO: 848, SEQ ID NO: 888, and SEQ ID NO: 928, SEQ ID NO:968, and SEQ ID NO:1008; and/or   (b) a variable light chain comprising a CDR1 sequence selected from the group consisting of SEQ ID NO: 24, SEQ ID NO: 64, SEQ ID NO: 104, SEQ ID NO: 144, SEQ ID NO: 184, SEQ ID NO: 224, SEQ ID NO: 264, SEQ ID NO: 344, SEQ ID NO: 384, SEQ ID NO: 424, SEQ ID NO: 464, SEQ ID NO: 504, SEQ ID NO: 544, SEQ ID NO: 584, SEQ ID NO: 624, SEQ ID NO: 664, SEQ ID NO: 704, SEQ ID NO: 744, SEQ ID NO: 784, SEQ ID NO: 824, SEQ ID NO: 864, SEQ ID NO: 904, SEQ ID NO: 944, SEQ ID NO:984, SEQ ID NO:1024, a CDR2 sequence selected from the group consisting of SEQ ID NO: 26, SEQ ID NO: 66, SEQ ID NO: 106, SEQ ID NO: 146, SEQ ID NO: 186, SEQ ID NO: 226, SEQ ID NO: 266, SEQ ID NO: 346, SEQ ID NO: 386, SEQ ID NO: 426, SEQ ID NO: 466, SEQ ID NO: 506, SEQ ID NO: 546, SEQ ID NO: 586, SEQ ID NO: 626, SEQ ID NO: 666, SEQ ID NO: 706, SEQ ID NO: 746, SEQ ID NO: 786, SEQ ID NO: 826, SEQ ID NO: 866, SEQ ID NO: 906, SEQ ID NO: 946, SEQ ID NO:986, and SEQ ID NO:1026; and a CDR3 sequence selected from the group consisting of SEQ ID NO: 28, SEQ ID NO: 68, SEQ ID NO: 108, SEQ ID NO: 148, SEQ ID NO: 188, SEQ ID NO: 228, SEQ ID NO: 268, SEQ ID NO: 348, SEQ ID NO: 388, SEQ ID NO: 428, SEQ ID NO: 468, SEQ ID NO: 508, SEQ ID NO: 548, SEQ ID NO: 588, SEQ ID NO: 628, SEQ ID NO: 668, SEQ ID NO: 708, SEQ ID NO: 748, SEQ ID NO: 788, SEQ ID NO: 828, SEQ ID NO: 868, SEQ ID NO: 908, SEQ ID NO: 948, SEQ ID NO:988, and SEQ ID NO:1028;   (v) the variable heavy chain of said antibody or antibody fragment comprises the CDR1 sequence of SEQ ID NO: 4, the CDR2 sequence of SEQ ID NO: 6, and the CDR3 sequence of SEQ ID NO: 8; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 24, the CDR2 sequence of SEQ ID NO: 26, and the CDR3 sequence of SEQ ID NO: 28;   (vi) said anti-human HGF antibody or antibody fragment contains a variable heavy chain comprising the CDR1 sequence of SEQ ID NO: 44, the CDR2 sequence of SEQ ID NO: 46, and the CDR3 sequence of SEQ ID NO: 48; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 64, the CDR2 sequence of SEQ ID NO: 66, and the CDR3 sequence of SEQ ID NO: 68;   (vii) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the CDR1 sequence of SEQ ID NO: 84, the CDR2 sequence of SEQ ID NO: 86, and the CDR3 sequence of SEQ ID NO: 88; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 104, the CDR2 sequence of SEQ ID NO: 106, and the CDR3 sequence of SEQ ID NO: 108;   (viii) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the CDR1 sequence of SEQ ID NO: 124, the CDR2 sequence of SEQ ID NO: 126, and the CDR3 sequence of SEQ ID NO: 128; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 144, the CDR2 sequence of SEQ ID NO: 146, and the CDR3 sequence of SEQ ID NO: 148;   (ix) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the CDR1 sequence of SEQ ID NO: 164, the CDR2 sequence of SEQ ID NO: 166, and the CDR3 sequence of SEQ ID NO: 168; and the variable light chain comprises the CDR1 sequence of SEQ ID NO: 184, the CDR2 sequence of SEQ ID NO: 186, and the CDR3 sequence of SEQ ID NO: 188;   (x) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the CDR1 sequence of SEQ ID NO: 204, the CDR2 sequence of SEQ ID NO: 206, and the CDR3 sequence of SEQ ID NO: 208; and the variable light chain comprises the CDR1 sequence of SEQ ID NO: 224, the CDR2 sequence of SEQ ID NO: 226, and the CDR3 sequence of SEQ ID NO: 228;   (xi) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the CDR1 sequence of SEQ ID NO: 244, the CDR2 sequence of SEQ ID NO: 246, and the CDR3 sequence of SEQ ID NO: 248; and the variable light chain comprises the CDR1 sequence of SEQ ID NO: 264, the CDR2 sequence of SEQ ID NO: 266, and the CDR3 sequence of SEQ ID NO: 268;   (xii) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the CDR1 sequence of SEQ ID NO: 324, the CDR2 sequence of SEQ ID NO: 326, and the CDR3 sequence of SEQ ID NO: 328; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 344, the CDR2 sequence of SEQ ID NO: 346, and the CDR3 sequence of SEQ ID NO: 348;   (xiii) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the CDR1 sequence of SEQ ID NO: 364, the CDR2 sequence of SEQ ID NO: 366, and the CDR3 sequence of SEQ ID NO: 368; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 384, the CDR2 sequence of SEQ ID NO: 386, and the CDR3 sequence of SEQ ID NO: 388;   (xiv) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the CDR1 sequence of SEQ ID NO: 404, the CDR2 sequence of SEQ ID NO: 406, and the CDR3 sequence of SEQ ID NO: 408; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 424, the CDR2 sequence of SEQ ID NO: 426, and the CDR3 sequence of SEQ ID NO: 428;   (xv) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the CDR1 sequence of SEQ ID NO: 444, the CDR2 sequence of SEQ ID NO: 446, and the CDR3 sequence of SEQ ID NO: 448; and the variable light chain comprises the CDR1 sequence of SEQ ID NO: 464, the CDR2 sequence of SEQ ID NO: 466, and the CDR3 sequence of SEQ ID NO: 468;   (xvi) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the variable heavy chain comprises the CDR1 sequence of SEQ ID NO: 484, the CDR2 sequence of SEQ ID NO: 486, and the CDR3 sequence of SEQ ID NO: 488; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 504, the CDR2 sequence of SEQ ID NO: 506, and the CDR3 sequence of SEQ ID NO: 508;   (xvii) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the variable heavy chain comprises the CDR1 sequence of SEQ ID NO: 524, the CDR2 sequence of SEQ ID NO: 526, and the CDR3 sequence of SEQ ID NO: 528; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 544, the CDR2 sequence of SEQ ID NO: 546, and the CDR3 sequence of SEQ ID NO: 548;   (xviii) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the variable heavy chain comprises the CDR1 sequence of SEQ ID NO: 564, the CDR2 sequence of SEQ ID NO: 566, and the CDR3 sequence of SEQ ID NO: 568; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 584, the CDR2 sequence of SEQ ID NO: 586, and the CDR3 sequence of SEQ ID NO: 588;   (xix) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the variable heavy chain comprises the CDR1 sequence of SEQ ID NO: 604, the CDR2 sequence of SEQ ID NO: 606, and the CDR3 sequence of SEQ ID NO: 608; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 624, the CDR2 sequence of SEQ ID NO: 626, and the CDR3 sequence of SEQ ID NO: 628;   (xx) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the variable heavy chain comprises the CDR1 sequence of SEQ ID NO: 644, the CDR2 sequence of SEQ ID NO: 646, and the CDR3 sequence of SEQ ID NO: 648; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 664, the CDR2 sequence of SEQ ID NO: 666, and the CDR3 sequence of SEQ ID NO: 668;   (xxi) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the variable heavy chain comprises the CDR1 sequence of SEQ ID NO: 684, the CDR2 sequence of SEQ ID NO: 686, and the CDR3 sequence of SEQ ID NO: 688; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 704, the CDR2 sequence of SEQ ID NO: 706, and the CDR3 sequence of SEQ ID NO: 708;   (xxii) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the variable heavy chain comprises the CDR1 sequence of SEQ ID NO: 724, the CDR2 sequence of SEQ ID NO: 726, and the CDR3 sequence of SEQ ID NO: 728; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 744, the CDR2 sequence of SEQ ID NO: 746, and the CDR3 sequence of SEQ ID NO: 748;   (xxiii) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the CDR1 sequence of SEQ ID NO: 764, the CDR2 sequence of SEQ ID NO: 766, and the CDR3 sequence of SEQ ID NO: 768; and/or a variable light chain comprising the CDR1 sequence of SEQ ID NO: 784, the CDR2 sequence of SEQ ID NO: 786, and the CDR3 sequence of SEQ ID NO: 788;   (xxiv) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the variable heavy chain comprises the CDR1 sequence of SEQ ID NO: 804, the CDR2 sequence of SEQ ID NO: 806, and the CDR3 sequence of SEQ ID NO: 808; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 824, the CDR2 sequence of SEQ ID NO: 826, and the CDR3 sequence of SEQ ID NO: 828;   (xxv) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the variable heavy chain comprises the CDR1 sequence of SEQ ID NO: 844, the CDR2 sequence of SEQ ID NO: 846, and the CDR3 sequence of SEQ ID NO: 848; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 864, the CDR2 sequence of SEQ ID NO: 866, and the CDR3 sequence of SEQ ID NO: 868;   (xxvi) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the CDR1 sequence of SEQ ID NO: 884, the CDR2 sequence of SEQ ID NO: 886, and the CDR3 sequence of SEQ ID NO: 888; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 904, the CDR2 sequence of SEQ ID NO: 906, and the CDR3 sequence of SEQ ID NO: 908;   (xxvii) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the CDR1 sequence of SEQ ID NO: 924, the CDR2 sequence of SEQ ID NO: 926, and the CDR3 sequence of SEQ ID NO: 928; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 944, the CDR2 sequence of SEQ ID NO: 946, and the CDR3 sequence of SEQ ID NO: 948;   (xxviii) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the CDR1 sequence of SEQ ID NO: 964, the CDR2 sequence of SEQ ID NO: 966, and the CDR3 sequence of SEQ ID NO: 968; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 984, the CDR2 sequence of SEQ ID NO: 986, and the CDR3 sequence of SEQ ID NO: 988;   (xxix) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprising the CDR1 sequence of SEQ ID NO: 1004, the CDR2 sequence of SEQ ID NO: 1006, and the CDR3 sequence of SEQ ID NO: 1008; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 1024, the CDR2 sequence of SEQ ID NO: 1026, and the CDR3 sequence of SEQ ID NO: 1028;   (xxx) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain that comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 2 and/or the variable light chain comprises SEQ ID NO: 22;   (xxxi) said anti-human HGF antibody or antibody fragment comprises a variable heavy and light chains which are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 2 and SEQ ID NO: 22, respectively;   (xxxii) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 42 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 62;   (xxxiii) said anti-human HGF antibody or antibody fragment comprises a variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 42 and SEQ ID NO: 62, respectively;   (xxxiv) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprises a sequence which is at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 82 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 102;   (xxxv) said anti-human HGF antibody or antibody fragment comprises a variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 82 and SEQ ID NO: 102, respectively;   (xxxvi) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain that comprises a sequence which is at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 122 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 142;   (xxxvii) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains which are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 122 and SEQ ID NO: 142, respectively;   (xxxviii) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain which comprises a sequence that is at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 162 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 182;   (xxxix) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains which are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 162 and SEQ ID NO: 182, respectively;   (xxxx) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 202 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 222;   (xxxxi) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains which are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 202 and SEQ ID NO: 222, respectively;   (xxxxii) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain that comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 242 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 262;   (xxxxiii) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains which are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 242 and SEQ ID NO: 262, respectively;   (xxxxiv) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 322 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 342;   (xxxxv) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains which are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 322 and SEQ ID NO: 342, respectively;   (xxxxvi) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 362 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 382;   (xxxxvii) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 362 and SEQ ID NO: 382, respectively;   (xxxxviii) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 402 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 422;   (xxxxix) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 402 and SEQ ID NO: 422, respectively;   (1) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 442 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 462;   (1i) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 442 and SEQ ID NO: 462, respectively;   (1ii) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 482 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 502;   (1iii) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains which are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 482 and SEQ ID NO: 502, respectively;   (1iv) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 522 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 542;   (1v) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 522 and SEQ ID NO: 542, respectively;   (1vi) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 562 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 582;   (1vii) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 562 and SEQ ID NO: 582, respectively;   (1viii) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 602 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 622;   (1vix) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 602 and SEQ ID NO: 622, respectively;   (1x) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 642 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 662;   (1xi) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 642 and SEQ ID NO: 662, respectively;   (1xii) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 682 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 702;   (1xiii) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 682 and SEQ ID NO: 702, respectively;   (1xiv) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 722 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 742;   (1xv) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 722 and SEQ ID NO: 742, respectively;   (1xvi) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 762 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 782;   (1xvii) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains which are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 762 and SEQ ID NO: 782, respectively;   (1xviii) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 802 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 822;   (1xix) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 802 and SEQ ID NO: 822, respectively;   (1xx) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 842 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 862;   (1xxi) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 842 and SEQ ID NO: 862, respectively;   (1xxii) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 882 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 902;   (1xxiii) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 882 and SEQ ID NO: 902, respectively;   (1xxiv) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 922 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 942;   (1xxv) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains which are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 922 and SEQ ID NO: 942, respectively;   (1xxvi) said anti-human HGF antibody or antibody fragment comprises a variable heavy chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 962 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 982;   (1xxvii) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 962 and SEQ ID NO: 982, respectively;   (1xxviii) said anti-human HGF antibody or antibody fragment a variable heavy chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 1002 and the variable light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 1022;   (1xxix) said anti-human HGF antibody or antibody fragment comprises variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 1002 and SEQ ID NO: 1022, respectively;   (1xxx) said anti-human HGF antibody or antibody fragment comprises a heavy chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 1 and the light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 21;   (1xxxi) said anti-human HGF antibody or antibody fragment comprises a heavy chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 41 and a light chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 61;   (1xxxii) said anti-human HGF antibody or antibody fragment comprises a heavy chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 81 and a light chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 101;   (1xxxiii) said anti-human HGF antibody or antibody fragment comprises a heavy chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 121 and a light chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 141;   (1xxxiv) said anti-human HGF antibody or antibody fragment comprises a heavy chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 161 and the light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 181;   (1xxxv) said anti-human HGF antibody or antibody fragment comprises a heavy chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 201 and the light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 221;   (1xxxvi) said anti-human HGF antibody or antibody fragment comprises a heavy chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 241 and the light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 261;   (1xxxvii) said anti-human HGF antibody or antibody fragment comprises a heavy chain which comprises SEQ ID NO: 321 and a light chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 341;   (1xxxviii) said anti-human HGF antibody or antibody fragment comprises a heavy chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 361 and the light chain comprises SEQ ID NO: 381;   (1xxxix) said anti-human HGF antibody or antibody fragment comprises a heavy chain comprises SEQ ID NO: 401 and the light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 421;   (1xxxx) said anti-human HGF antibody or antibody fragment comprises a heavy chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 441 and the light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 461;   (1xxxxi) said anti-human HGF antibody or antibody fragment comprises a heavy chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 481 and the light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 501;   (1xxxxii) said anti-human HGF antibody or antibody fragment comprises a heavy chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 521 and the light chain comprises SEQ ID NO: 541;   (1xxxxiii) said anti-human HGF antibody or antibody fragment comprises a heavy chain comprises SEQ ID NO: 561 and the light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 581;   (1xxxxiv) said anti-human HGF antibody or antibody fragment comprises a heavy chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 601 and the light chain comprises SEQ ID NO: 621;   (1xxxxv) said anti-human HGF antibody or antibody fragment comprises a heavy chain comprises SEQ ID NO: 641 and the light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 661;   (1xxxxvi) said anti-human HGF antibody or antibody fragment comprises a heavy chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 681 and the light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 701;   (1xxxxvii) said anti-human HGF antibody or antibody fragment comprises a heavy chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 721 and the light chain comprises SEQ ID NO: 741;   (1xxxxviii) said anti-human HGF antibody or antibody fragment comprises a heavy chain which comprises SEQ ID NO: 761 and the light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 781;   (1xxxxix) said anti-human HGF antibody or antibody fragment comprises a heavy chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 801 and the light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 821;   (c) said anti-human HGF antibody or antibody fragment comprises a heavy chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 841 and the light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 861;   (ci) said anti-human HGF antibody or antibody fragment comprises a heavy chain which comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 881 and the light chain comprises SEQ ID NO: 901;   (cii) said anti-human HGF antibody or antibody fragment comprises a heavy chain which comprises SEQ ID NO: 921 and the light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 941;   (ciii) said anti-human HGF antibody or antibody fragment comprises a heavy chain which comprises SEQ ID NO: 961 and the light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 981; and   (civ) said anti-human HGF antibody or antibody fragment comprises a heavy chain which comprises SEQ ID NO: 1001 and the light chain comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 1021; or any combination of the foregoing.   
     
     
         345 . The anti-human HGF antibody or antibody fragment of  claim 343 , wherein the antibody or antibody fragment comprises:
 (i) a chimeric, humanized, and human antibody or antibody fragment;   (ii) an scFv, camelbody, nanobody, IgNAR, Fab fragment, Fab′ fragment, MetMab like antibody, monovalent antibody fragment, and/or an F(ab′)2 fragment;   (iii) an antibody or antibody fragment that substantially or entirely lacks N-glycosylation and/or O-glycosylation;   (iv) an antibody or antibody fragment which comprises a human constant domain;   (v) a human which contains human IgG1, IgG2, IgG3, or IgG4 antibody constant regions;   (vi) an antibody or antibody fragment which comprises an Fc region that has been modified to alter at least one of effector function, half-life, proteolysis, or glycosylation;   (vii) an antibody which contains an Fc region which contains one or more mutations that alters or eliminates N- and/or O-glycosylation;   (viii) a humanized antibody or antibody fragment;   (ix) an antibody or antibody fragment which binds to HGF with a dissociation constant (K D ) of less than or equal to 10 −2  M, 5×10 −3  M, 10 −3  M, 5×10 −4  M, 10 −4  M, 5×10 −5  M, 10 −5  M, 5×10 −6  M, 10 −6  M, 5×10 −7  M, 10 −7  M, 5×10 −8  M, 10 −8  M, 5×10 −9  M, 10 −9  M, 5×10 −1 ° M, 10 −10  M, 5×10 −11  M, 10 −11  M, 5×10 −12 M, 10 −12  M, 5×10 −13 M, or 10 −13  M;   (x) an antibody or antibody fragment binds to HGF with a dissociation constant (K D ) of less than or equal to 10 −11  M, 5×10 −12  M, or 10 −12  M;   (xi) an antibody or antibody fragment that binds to HGF with an off-rate (K off ) of less than or equal to 10 −4  S −1 , 5×10 −5  S −1 , 10 −5  S −1 , 5×10 −6  S −1 , 10 −6  S −1 , 5×10 −7  S −1 , or 10 −7  S −1 ;   (xii) an antibody or antibody fragment which directly or indirectly attached to a detectable label or therapeutic agent;   (xiii) an antibody or antibody fragment which when administered to a human subject inhibits or neutralizes at least one biological effect elicited by HGF;   (xiv) an antibody or antibody fragment which binds to HGF with a K D  that is less than about 100 nM;   (xv) an antibody or antibody fragment which binds to HGF with a K D  that is less than about 10 nM;   (xvi) an antibody or antibody fragment which binds to HGF with a K D  that is less than about 1 nM;   (xvii) an antibody or antibody fragment which binds to HGF with a K D  that is between about 1 and about 10 nM;   (xviii) the antibody or antibody fragment binds to HGF with a K D  that is between about 0.1 and about 1 nM;   (xix) an antibody or antibody fragment which is attached to at least one effector moiety, optionally comprising a chemical linker;   (xx) an antibody or antibody fragment which is attached to one or more detectable moieties;   (xxi) an antibody or antibody fragment which is attached to a detectable moiety that comprises a fluorescent dye, enzyme, substrate, bioluminescent material, radioactive material, chemiluminescent moiety, or mixtures thereof;   (xxii) an antibody or antibody fragment which is attached to one or more functional moieties; and/or   (xxiii) an anti-idiotypic antibody produced against an anti-human HGF antibody or antibody fragment according to any one of the foregoing.   
     
     
         346 . A composition suitable for therapeutic, prophylaxis, or a diagnostic use comprising a therapeutically, prophylactically or diagnostically effective amount of at least one antibody or antibody fragment according to  claim 343 . 
     
     
         347 . A composition according to  claim 346 , wherein:
 (i) it is suitable for administration by a means selected from buccal, epicutaneous, epidural, inhalation, intraarterial, intracardial, intracerebroventricular, intradermal, intramuscular, intranasal, intraocular, intraperitoneal, intraspinal, intrathecal, intravenous, oral, parenteral, topical, rectally via an enema or suppository, subcutaneous, subdermal, sublingual, transdermal, and transmucosal;   (ii) it comprises a powder, liquid, gel, drop, liposomal, or other dosage form;   (iii) it is lyophilized;   (iv) it comprises a pharmaceutically acceptable diluent, carrier, solubilizer, emulsifier, preservative, or mixture thereof;   (v) it comprises another active agent;   (vi) it comprises another active agent comprising a drug useful for treating a condition selected from cancer, macular degeneration, Alzheimer's disease, and malarial infection;   (vii) it comprises another active agent for treating a cancer is selected from cancer ovarian cancer, breast cancer, lung cancer (small cell or non-small cell), colon and colorectal cancer, prostate cancer, pancreatic cancer, renal cancer, gastric cancer, liver cancer, bladder cancer, thyroid cancer, endometrial cancer, head-and-neck tumors, melanoma, sarcomas, leukemias, lymphomas, and brain tumors (e.g., glioblastomas), of children or adults;   (viii) it comprises another active agent selected from chemotherapy agents, statins, cytokines, immunosuppressive agents, gene therapy agents, anti-coagulants, anti-cachexia agents, anti-weakness agent, anti-fatigue agent, anti-fever agent, anti-nausea agents, antiemetic agents, IL-6 antagonists, cytotoxic agents, analgesics, antipyretics, anti-inflammatory agents, antibiotics, antiviral agents, anti-cytokine agents, anti-angiogenesis agents, or any combination thereof;   (ix) it comprises another active agent which is a chemotherapy agent selected from: VEGF antagonists, EGFR antagonists, platins, taxols, irinotecan, 5-fluorouracil, gemcitabine, leucovorin, steroids, cyclophosphamide, melphalan, vinca alkaloids, vinblastine, vincristine, vindesine, vinorelbine, mustines, tyrosine kinase inhibitors, radiotherapy, sex hormone antagonists, selective androgen receptor modulators, selective estrogen receptor modulators, PDGF antagonists, TNF antagonists, IL-1 antagonists, interleukins, IL-12, IL-2, IL-12R antagonists, Toxin conjugated monoclonal antibodies, tumor antigen specific monoclonal antibodies, Erbitux™, Avastin™, Pertuzumab, anti-CD20 antibodies, Rituxan®, ocrelizumab, ofatumumab, DXL625, Herceptin®, or any combination thereof;   (x) it comprises another active agent which is an anti-coagulant selected from: abciximab (ReoPro™), acenocoumarol, antithrombin IE, argatroban, aspirin, bivalirudin (Angiomax™) clopidogrel, dabigatran, dabigatran etexilate (Pradaxa™/Pradax™), desirudin (Revasc™/Iprivask™), dipyridamole, eptifibatide (Integrilin™), fondaparinux, heparin, hirudin, idraparinux, lepirudin (Refludan™), low molecular weight heparin, Melagatran, phenindione, phenprocoumon, ticlopidine, tirofiban (Aggrastat™), warfarin, ximelagatran, ximelagatran (Exanta™/Exarta™), or any combination thereof;   (xi) it comprises another active agent which is a statin selected from: atorvastatin, cerivastatin, fluvastatin, lovastatin, mevastatin, pravastatin, pravastatin, rosuvastatin, simvastatin, or any combination thereof;   (xii) it comprises another active agent which is an antagonist of a factor selected from tumor necrosis factor-alpha, Interferon gamma, Interleukin 1 alpha, Interleukin 1 beta, Interleukin 6, proteolysis inducing factor, leukemia-inhibitory factor, or any combination thereof;   (xiii) it comprises another active agent which is an anti-angiogenesis factor selected from soluble VEGFR-1, NRP-1, Angiopoietin 2, TSP-1 and TSP-2, angiostatin and related molecules, endostatin, vasostatin, calreticulin, platelet factor-4, TIMP, CDAI, Meth-1, Meth-2, IFN-α, -β and -γ, CXCL10, IL-4, IL-12, IL-18, prothrombin (kringle domain-2), antithrombin III fragment, prolactin, VEGI, SPARC, osteopontin, maspin, and canstatin;   (xiv) it comprises another active agent which is an anti-cachexia agent comprising:  cannabis , dronabinol (Marinol™), nabilone (Cesamet), cannabidiol, cannabichromene, tetrahydrocannabinol, Sativex, megestrol acetate, or any combination thereof;   (xv) it comprises another active agent which is an anti-nausea agent or antiemetic agent is comprising: 5-HT3 receptor antagonists, ajwain, alizapride, anticholinergics, antihistamines, aprepitant, benzodiazepines, cannabichromene, cannabidiol, cannabinoids,  cannabis , casopitant, chlorpromazine, cyclizine, dexamethasone, dexamethasone, dimenhydrinate (Gravol™), diphenhydramine, dolasetron, domperidone, dopamine antagonists, doxylamine, dronabinol (Marinol™), droperidol, emetrol, ginger, granisetron, haloperidol, hydroxyzine, hyoscine, lorazepam, meclizine, metoclopramide, midazolam, muscimol, nabilone (Cesamet), nk1 receptor antagonists, ondansetron, palonosetron, peppermint, Phenergan, prochlorperazine, Promacot, promethazine, Pentazine, propofol, sativex, tetrahydrocannabinol, trimethobenzamide, tropisetron, nandrolone, stilbestrol, thalidomide, lenalidomide, ghrelin agonists, myostatin antagonists, anti-myostatin antibodies, selective androgen receptor modulators, selective estrogen receptor modulators, angiotensin All antagonists, beta two adenergic receptor agonists, beta three adenergic receptor agonists, or any combination thereof;   (xvi) it comprises another active agent which is selected from tamoxifen, BCL-2 antagonists, estrogen, bisphosphonates, teriparatide, strontium ranelate, sodium alendronate (Fosamax), risedronate (Actonel), raloxifene, ibandronate (Boniva), Obatoclax, ABT-263, gossypol, gefitinib, epidermal growth factor receptor tyrosine kinase inhibitors, erlotinib, epidermal growth factor receptor inhibitors, psoralens, trioxysalen, methoxsalen, bergapten, retinoids, etretinate, acitretin, infliximab (Remicade®), adalimumab, infliximab, etanercept, Zenapax™, Cyclosporine, Methotrexate, granulocyte-colony stimulating factor, filgrastim, lenograstim, Neupogen, Neulasta, 2-Arylpropionic acids, Aceclofenac, Acemetacin, Acetylsalicylic acid (Aspirin), Alclofenac, Alminoprofen, Amoxiprin, Ampyrone, Arylalkanoic acids, Azapropazone, Benorylate/Benorilate, Benoxaprofen, Bromfenac, Carprofen, Celecoxib, Choline magnesium salicylate, Clofezone, COX-2 inhibitors, Dexibuprofen, Dexketoprofen, Diclofenac, Diflunisal, Droxicam, Ethenzamide, Etodolac, Etoricoxib, Faislamine, fenamic acids, Fenbufen, Fenoprofen, Flufenamic acid, Flunoxaprofen, Flurbiprofen, Ibuprofen, Ibuproxam, Indometacin, Indoprofen, Kebuzone, Ketoprofen, Ketorolac, Lornoxicam, Loxoprofen, Lumiracoxib, Magnesium salicylate, Meclofenamic acid, Mefenamic acid, Meloxicam, Metamizole, Methyl salicylate, Mofebutazone, Nabumetone, Naproxen, N-Arylanthranilic acids, Oxametacin, Oxaprozin, Oxicams, Oxyphenbutazone, Parecoxib, Phenazone, Phenylbutazone, Phenylbutazone, Piroxicam, Pirprofen, profens, Proglumetacin, Pyrazolidine derivatives, Rofecoxib, Salicyl salicylate, Salicylamide, Salicylates, Sulfinpyrazone, Sulindac, Suprofen, Tenoxicam, Tiaprofenic acid, Tolfenamic acid, Tolmetin, and Valdecoxib; Antibiotics; Amikacin, Aminoglycosides, Amoxicillin, Ampicillin, Ansamycins, Arsphenamine, Azithromycin, Azlocillin, Aztreonam, Bacitracin, Carbacephem, Carbapenems, Carbeni cillin, Cefaclor, Cefadroxil, Cefalexin, Cefalothin, Cefalotin, Cefamandole, Cefazolin, Cefdinir, Cefditoren, Cefepime, Cefixime, Cefoperazone, Cefotaxime, Cefoxitin, Cefpodoxime, Cefprozil, Ceftazidime, Ceftibuten, Ceftizoxime, Ceftobiprole, Ceftriaxone, Cefuroxime, Cephalosporins, Chloramphenicol, Cilastatin, Ciprofloxacin, Clarithromycin, Clindamycin, Cloxacillin, Colistin, Co-trimoxazole, Dalfopristin, Demeclocycline, Dicloxacillin, Dirithromycin, Doripenem, Doxycycline, Enoxacin, Ertapenem, Erythromycin, Ethambutol, Flucloxacillin, Fosfomycin, Furazolidone, Fusidic acid, Gatifloxacin, Geldanamycin, Gentamicin, Glycopeptides, Herbimycin, Imipenem, Isoniazid, Kanamycin, Levofloxacin, Lincomycin, Linezolid, Lomefloxacin, Loracarbef, Macrolides, Mafenide, Meropenem, Meticillin, Metronidazole, Mezlocillin, Minocycline, Monobactams, Moxifloxacin, Mupirocin, Nafcillin, Neomycin, Netilmicin, Nitrofurantoin, Norfloxacin, Ofloxacin, Oxacillin, Oxytetracycline, Paromomycin, Penicillin, Penicillins, Piperacillin, Platensimycin, Polymyxin B, Polypeptides, Prontosil, Pyrazinamide, Quinolones, Quinupristin, Rifampicin, Rifampin, Roxithromycin, Spectinomycin, Streptomycin, Sulfacetamide, Sulfamethizole, Sulfanamide, Sulfasalazine, Sulfisoxazole, Sulfonamides, Teicoplanin, Telithromycin, Tetracycline, Tetracyclines, Ticarcillin, Tinidazole, Tobramycin, Trimethoprim, Trimethoprim-Sulfamethoxazole, Troleandomycin, Trovafloxacin, Vancomycin; Aldosterone, Beclometasone, Betamethasone, Corticosteroids, Cortisol, Cortisone acetate, Deoxycorticosterone acetate, Dexamethasone, Fludrocortisone acetate, Glucocorticoids, Hydrocortisone, Methylprednisolone, Prednisolone, Prednisone, Steroids, and Triamcinolone; Antiviral agents including by way of example abacavir, aciclovir, acyclovir, adefovir, amantadine, amprenavir, an antiretroviral fixed dose combination, an antiretroviral synergistic enhancer, arbidol, atazanavir, atripla, brivudine, cidofovir, combivir, darunavir, delavirdine, didanosine, docosanol, edoxudine, efavirenz, emtricitabine, enfuvirtide, entecavir, entry inhibitors, famciclovir, fomivirsen, fosamprenavir, foscarnet, fosfonet, fusion inhibitor, ganciclovir, gardasil, ibacitabine, idoxuridine, imiquimod, imunovir, indinavir, inosine, integrase inhibitor, interferon, interferon type I, interferon type II, interferon type III, lamivudine, lopinavir, loviride, maraviroc, MK-0518, moroxydine, nelfinavir, nevirapine, nexavir, nucleoside analogues, oseltamivir, penciclovir, peramivir, pleconaril, podophyllotoxin, protease inhibitor, reverse transcriptase inhibitor, ribavirin, rimantadine, ritonavir, saquinavir, stavudine, tenofovir, tenofovir disoproxil, tipranavir, trifluridine, trizivir, tromantadine, truvada, valaciclovir, valganciclovir, vicriviroc, vidarabine, viramidine, zalcitabine, zanamivir, zidovudine, or any combination thereof;   (xvii) it comprises another active agent which is a cytotoxic agent, chemotherapeutic agent, or immunosuppressive agent is comprising: 1-dehydrotestosterone, 1-methylnitrosourea, 5-fluorouracil, 6-mercaptopurine, 6-mercaptopurine, 6-thioguanine, Abatacept, abraxane, acitretin, aclarubicin, Actinium-225 ( 225 Ac), actinomycin, Adalimumab, adenosine deaminase inhibitors, Afelimomab, Aflibercept, Afutuzumab, Alefacept, alitretinoin, alkyl sulfonates, alkylating agents, altretamine, alvocidib, aminolevulinic acid/methyl aminolevulinate, aminopterin, aminopterin, amrubicin, amsacrine, amsacrine, anagrelide, Anakinra, anthracenediones, anthracyclines, anthracyclines, anthracyclines, anthramycin (AMC); antimytotic agents, antibiotics, anti-CD20 antibodies, antifolates, Anti-lymphocyte globulin, Antimetabolites, Anti-thymocyte globulin, arsenic trioxide, Aselizumab, asparaginase, asparagine depleters, Astatine-211 ( 211 At), Atlizumab, Atorolimumab, atrasentan, Avastin™ azacitidine, Azathioprine, azelastine, aziridines, Basiliximab, BAYX antibodies, Belatacept, Belimumab, belotecan, bendamustine, Bertilimumab, bexarotene, bisantrene, Bismuth-213 ( 213 Bi), Bismuth-212 ( 212 Bi), bleomycin, bleomycin, bleomycin, BLyS antibodies, bortezomib, busulfan, busulfan, Calcineurin inhibitors, calicheamicin, camptothecin, camptothecins, capecitabine, carboplatin (paraplatin), carboquone, carminomycin, carmofur, carmustine, carmustine (BSNU), CAT antibodies, CD11a antibodies, CD147/Basigin antibodies, CD154 antibodies, CD18 antibodies, CD20 antibodies, CD23 antibodies, CD3 antibodies, CD4 antibodies, CD40 antibodies, CD62L/L-selectin antibodies, CD80 antibodies, CDK inhibitors, Cedelizumab, celecoxib, Certolizumab pegol, chlorambucil, chlorambucils, Cyclosporin, cis-dichlorodiamine platinum (II) (DDP) cisplatin, cladribine, Clenoliximab, clofarabine, colchicin, Complement component 5 antibodies, Copper-67 (67Cu), corticosteroids, CTLA-4 antibodies, CTLA-4 fusion proteins, Cyclophilin inhibitors, cyclophosphamides, cyclothosphamide, cytarabine, cytarabine, cytochalasin B, cytotoxic ribonucleases, dacarbazine, Daclizumab, dactinomycin, dactinomycin (actinomycin D), daunorubicin, daunorubicin, daunorubicin (formerly daunomycin), decitabine, Deforolimus, demecolcine, detorubicin, dibromomannitol, diethylcarbamazine, dihydrofolate reductase inhibitors, dihydroxy anthracin dione, diphtheria toxin, DNA polymerase inhibitors, docetaxel, Dorlimomab aritox, Dorlixizumab, doxorubicin (adriamycin), DXL625, Eculizumab, Efalizumab, efaproxiral, EGFR antagonists, elesclomol, elsamitrucin, Elsilimomab, emetine, endothelin receptor antagonists, epipodophyllotoxins, epirubicin, epothilones, Erbitux™, Erlizumab, estramustine, Etanercept, ethidium bromide, etoglucid, etoposide, etoposide phosphate, Everolimus, Faralimomab, farnesyltransferase inhibitors, FKBP inhibitors, floxuridine, fludarabine, fluorouracil, Fontolizumab, fotemustine, Galiximab, Gallium-67 (67Ga), Gantenerumab, Gavilimomab, gemcitabine, glucocorticoids, Golimumab, Gomiliximab, gramicidin D, Gusperimus, Herceptin®, hydrazines, hydroxyurea, hypomethylating agents, idarubicin, Idarubicine, ifosfamide, IL-1 antagonists, IL-1 receptor antagonists, IL-12, IL-12 antibodies, IL-12R antagonists, IL-13 antibodies, IL-2, IL-2 inhibitors, IL-2 receptor/CD25 antibodies, IL-6 antibodies, imatinib mesylate, Immunoglobulin E antibodies, IMP dehydrogenase inhibitors, Infliximab, Inolimomab, Integrin antibodies, Interferon antibodies, interferons, Interleukin 5 antibodies, Interleukin-6 receptor antibodies, interleukins, Iodine-125 ( 125 I) Iodine-131 ( 131 I), Ipilimumab, irinotecan, ixabepilone, Keliximab, larotaxel, Lead-212 ( 212 Pb) Lebrilizumab, Leflunomide, Lenalidomide, Lerdelimumab, leucovorine, LFA-I antibodies, lidocaine, lipoxygenase inhibitors, lomustine (CCNU), lonidamine, lucanthone, Lumiliximab, Lutetium-177 ( 177 Lu), Macrolides, mannosulfan, Maslimomab, masoprocol, mechlorethamine, melphalan, Mepolizumab, mercaptopurine, Metelimumab, Methotrexate, microtubule assembly inhibitors, microtubule stability enhancers, mithramycin, mitobronitol, mitoguazone, mitomycin, mitomycin C, mitotane, mitoxantrone, Morolimumab, mTOR inhibitors, Muromonab-CD3, mustines, Mycophenolic acid, mytotane (O,P′-(DDD)), Natalizumab, nedaplatin, Nerelimomab, nimustine, nitrogen mustards, nitrosoureas, nordihydroguaiaretic acid, oblimersen, ocrelizumab, Ocrelizumab, Odulimomab, ofatumumab, olaparib, Omalizumab, ortataxel, Otelixizumab, oxaliplatin, oxaliplatin, paclitaxel (taxol), Pascolizumab, PDGF antagonists, pegaspargase, pemetrexed, Pentostatin, Pertuzumab, Pexelizumab, phosphodiesterase inhibitors, Phosphorus-32 ( 32 P), Pimecrolimus Abetimus, pirarubicin, pixantrone, platins, plicamycin, poly ADP ribose polymerase inhibitors, porfimer sodium, porphyrin derivatives, prednimustine, procaine, procarbazine, procarbazine, propranolol, proteasome inhibitors,  pseudomonas  exotoxin,  Pseudomonas  toxin, purine synthesis inhibitors, puromycin, pyrimidine synthesis inhibitors, radionuclides, radiotherapy, raltitrexed, ranimustine, Reslizumab, retinoid X receptor agonists, retinoids, Rhenium-186 ( 186 Re), Rhenium-188 ( 188 Re), ribonucleotide reductase inhibitors, ricin, Rilonacept, Rituxan®, Rovelizumab, rubitecan, Ruplizumab, Samarium-153 ( 153 Sm), satraplatin, Scandium-47 ( 47 Sc), selective androgen receptor modulators, selective estrogen receptor modulators, seliciclib, semustine, sex hormone antagonists, Siplizumab, Sirolimus, steroid aromatase inhibitors, steroids, streptozocin, streptozotocin, Tacrolimus, talaporfin, Talizumab, taxanes, taxols, tegafur, Telimomab aritox, temoporfin, temozolomide, temsirolimus, Temsirolimus, Teneliximab, teniposide, Teplizumab, Teriflunomide, tesetaxel, testolactone, tetracaine, Thalidomide, thioepa chlorambucil, thiopurines thioguanine, ThioTEPA, thymidylate synthase inhibitors, tiazofurin, tipifarnib, T-lymphocyte antibodies, TNF antagonists, TNF antibodies, TNF fusion proteins, TNF receptor fusion proteins, TNF-alpha inhibitors, Tocilizumab, topoisomerase inhibitors, topotecan, Toralizumab, trabectedin, Tremelimumab, treosulfan, tretinoin, triazenes, triaziquone, triethylenemelamine, triplatin tetranitrate, trofosfamide, tumor antigen specific monoclonal antibodies, tyrosine kinase inhibitors, uramustine, Ustekinumab, valrubicin, Valrubicine, Vapaliximab, VEGF antagonists, Vepalimomab, verteporfin, vinblastine, vinca alkaloids, vincristine, vindesine, vinflunine, vinorelbine, Visilizumab, vorinostat, Yttrium-88 ( 88 Y), Yttrium-90 ( 90 Y), Zanolimumab, zileuton, Ziralimumab, Zolimomab aritox, zorubicin, Zotarolimus, or any combination thereof; and/or   (xviii) it comprises another active agent which is an agonist, antagonist, or modulator of a factor comprising: TNF-alpha, IL-2, IL-4, IL-6, IL-10, IL-12, IL-13, IL-18, IFN-alpha, IFN-gamma, BAFF, CXCL13, IP-10, VEGF, EPO, EGF, HRG, Hepatocyte Growth Factor (HGF), Hepcidin, or any combination thereof.   
     
     
         348 . An isolated nucleic acid or nucleic acids which encode for and which when expressed in a suitable host cell result in the expression of an anti-human HGF antibody or antibody fragment or the variable heavy or light chain thereof, which antibody or antibody fragment is (are) selected from:
 (i) said expressed antibody or antibody fragment encoded by said nucleic acid or nucleic acids contains the complementarity determining regions (CDRs) of an anti-HGF antibody selected from the group consisting of Ab1, Ab2, Ab3, Ab4, Ab5, Ab6, Ab7, Ab9, Ab10, Ab11, Ab12, Ab13, Ab14, Ab15, Ab16, Ab17, Ab18, Ab19, Ab20, Ab21, Ab23, Ab24, Ab25, Ab26, and Ab27;   (ii) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 4, the CDR2 sequence of SEQ ID NO: 6, and the CDR3 sequence of SEQ ID NO: 8; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 24, the CDR2 sequence of SEQ ID NO: 26, and the CDR3 sequence of SEQ ID NO: 28;   (iii) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 44, the CDR2 sequence of SEQ ID NO: 46, and the CDR3 sequence of SEQ ID NO: 48; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 64, the CDR2 sequence of SEQ ID NO: 66, and the CDR3 sequence of SEQ ID NO: 68;   (iv) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 84, the CDR2 sequence of SEQ ID NO: 86, and the CDR3 sequence of SEQ ID NO: 88; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 104, the CDR2 sequence of SEQ ID NO: 106, and the CDR3 sequence of SEQ ID NO: 108;   (v) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 124, the CDR2 sequence of SEQ ID NO: 126, and the CDR3 sequence of SEQ ID NO: 128; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 144, the CDR2 sequence of SEQ ID NO: 146, and the CDR3 sequence of SEQ ID NO: 148;   (vi) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 164, the CDR2 sequence of SEQ ID NO: 166, and the CDR3 sequence of SEQ ID NO: 168; and the variable light chain comprises the CDR1 sequence of SEQ ID NO: 184, the CDR2 sequence of SEQ ID NO: 186, and the CDR3 sequence of SEQ ID NO: 188;   (vii) said expressed anti-human HGF antibody or antibody fragment contains a variable heavy chain that comprises the CDR1 sequence of SEQ ID NO: 204, the CDR2 sequence of SEQ ID NO: 206, and the CDR3 sequence of SEQ ID NO: 208; and the variable light chain comprises the CDR1 sequence of SEQ ID NO: 224, the CDR2 sequence of SEQ ID NO: 226, and the CDR3 sequence of SEQ ID NO: 228;   (viii) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 244, the CDR2 sequence of SEQ ID NO: 246, and the CDR3 sequence of SEQ ID NO: 248; and the variable light chain comprises the CDR1 sequence of SEQ ID NO: 264, the CDR2 sequence of SEQ ID NO: 266, and the CDR3 sequence of SEQ ID NO: 268;   (ix) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 324, the CDR2 sequence of SEQ ID NO: 326, and the CDR3 sequence of SEQ ID NO: 328; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 344, the CDR2 sequence of SEQ ID NO: 346, and the CDR3 sequence of SEQ ID NO: 348;   (x) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 364, the CDR2 sequence of SEQ ID NO: 366, and the CDR3 sequence of SEQ ID NO: 368; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 384, the CDR2 sequence of SEQ ID NO: 386, and the CDR3 sequence of SEQ ID NO: 388;   (xi) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 404, the CDR2 sequence of SEQ ID NO: 406, and the CDR3 sequence of SEQ ID NO: 408; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 424, the CDR2 sequence of SEQ ID NO: 426, and the CDR3 sequence of SEQ ID NO: 428;   (xii) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 444, the CDR2 sequence of SEQ ID NO: 446, and the CDR3 sequence of SEQ ID NO: 448; and the variable light chain comprises the CDR1 sequence of SEQ ID NO: 464, the CDR2 sequence of SEQ ID NO: 466, and the CDR3 sequence of SEQ ID NO: 468;   (xiii) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 484, the CDR2 sequence of SEQ ID NO: 486, and the CDR3 sequence of SEQ ID NO: 488; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 504, the CDR2 sequence of SEQ ID NO: 506, and the CDR3 sequence of SEQ ID NO: 508;   (xiv) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 524, the CDR2 sequence of SEQ ID NO: 526, and the CDR3 sequence of SEQ ID NO: 528; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 544, the CDR2 sequence of SEQ ID NO: 546, and the CDR3 sequence of SEQ ID NO: 548;   (xv) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 564, the CDR2 sequence of SEQ ID NO: 566, and the CDR3 sequence of SEQ ID NO: 568; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 584, the CDR2 sequence of SEQ ID NO: 586, and the CDR3 sequence of SEQ ID NO: 588;   (xvi) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 604, the CDR2 sequence of SEQ ID NO: 606, and the CDR3 sequence of SEQ ID NO: 608; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 624, the CDR2 sequence of SEQ ID NO: 626, and the CDR3 sequence of SEQ ID NO: 628;   (xvii) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 644, the CDR2 sequence of SEQ ID NO: 646, and the CDR3 sequence of SEQ ID NO: 648; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 664, the CDR2 sequence of SEQ ID NO: 666, and the CDR3 sequence of SEQ ID NO: 668;   (xviii) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 684, the CDR2 sequence of SEQ ID NO: 686, and the CDR3 sequence of SEQ ID NO: 688; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 704, the CDR2 sequence of SEQ ID NO: 706, and the CDR3 sequence of SEQ ID NO: 708;   (xix) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 724, the CDR2 sequence of SEQ ID NO: 726, and the CDR3 sequence of SEQ ID NO: 728; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 744, the CDR2 sequence of SEQ ID NO: 746, and the CDR3 sequence of SEQ ID NO: 748;   (xx) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 764, the CDR2 sequence of SEQ ID NO: 766, and the CDR3 sequence of SEQ ID NO: 768; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 784, the CDR2 sequence of SEQ ID NO: 786, and the CDR3 sequence of SEQ ID NO: 788;   (xxi) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 804, the CDR2 sequence of SEQ ID NO: 806, and the CDR3 sequence of SEQ ID NO: 808; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 824, the CDR2 sequence of SEQ ID NO: 826, and the CDR3 sequence of SEQ ID NO: 828;   (xxii) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 844, the CDR2 sequence of SEQ ID NO: 846, and the CDR3 sequence of SEQ ID NO: 848; and/or the variable light chain comprises the CDR1 sequence of SEQ ID NO: 864, the CDR2 sequence of SEQ ID NO: 866, and the CDR3 sequence of SEQ ID NO: 868;   (xxiii) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 884, the CDR2 sequence of SEQ ID NO: 886, and the CDR3 sequence of SEQ ID NO: 888; and/or the variable light chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 904, the CDR2 sequence of SEQ ID NO: 906, and the CDR3 sequence of SEQ ID NO: 908;   (xxiv) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 924, the CDR2 sequence of SEQ ID NO: 926, and the CDR3 sequence of SEQ ID NO: 928; and/or the variable light chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 944, the CDR2 sequence of SEQ ID NO: 946, and the CDR3 sequence of SEQ ID NO: 948;   (xxv) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 964, the CDR2 sequence of SEQ ID NO: 966, and the CDR3 sequence of SEQ ID NO: 968; and/or the variable light chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 984, the CDR2 sequence of SEQ ID NO: 986, and the CDR3 sequence of SEQ ID NO: 988;   (xxvi) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 1004, the CDR2 sequence of SEQ ID NO: 1006, and the CDR3 sequence of SEQ ID NO: 1008; and/or the variable light chain encoded by said nucleic acid or nucleic acids comprises the CDR1 sequence of SEQ ID NO: 1024, the CDR2 sequence of SEQ ID NO: 1026, and the CDR3 sequence of SEQ ID NO: 1028;   (xxvii) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 2 and/or the variable light chain encoded by said nucleic acid or nucleic acids comprises SEQ ID NO: 22;   (xxviii) the variable heavy and light chains encoded by said nucleic acid are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 2 and SEQ ID NO: 22, respectively;   (xxix) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 42 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 62;   (xxx) the variable heavy and light chains encoded by said nucleic acid are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 42 and SEQ ID NO: 62, respectively;   (xxxi) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 82 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 102;   (xxxii) the variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 82 and SEQ ID NO: 102, respectively;   (xxxiii) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 122 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 142;   (xxxiv) the variable heavy and light chains encoded by said nucleic acid or acids are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 122 and SEQ ID NO: 142, respectively;   (xxxv) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 162 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 182;   (xxxvi) the variable heavy and light chains encoded by said nucleic acid or acids are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 162 and SEQ ID NO: 182, respectively;   (xxxvii) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 202 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 222;   (xxxviii) the variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 202 and SEQ ID NO: 222, respectively;   (xxxix) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 242 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 262;   (xxxx) the variable heavy and light chains encoded by said nucleic acid(s) are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 242 and SEQ ID NO: 262, respectively;   (xxxxi) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 322 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 342;   (xxxxii) the variable heavy and light chains encoded by said nucleic acid or nucleic acids are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 322 and SEQ ID NO: 342, respectively;   (xxxxiii) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 362 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 382;   (xxxxiv) the variable heavy and light chains encoded by said nucleic acid or nucleic acids are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 362 and SEQ ID NO: 382, respectively;   (xxxxv) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 402 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 422;   (xxxxvi) the variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 402 and SEQ ID NO: 422, respectively;   (xxxxvii) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 442 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 462;   (xxxxviii) the variable heavy and light chains encoded by said nucleic acid or nucleic acids are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 442 and SEQ ID NO: 462, respectively;   (xxxxix) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 482 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 502;   (1) the variable heavy and light chains encoded by said nucleic acid or nucleic acids are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 482 and SEQ ID NO: 502, respectively;   (1i) the variable heavy chain encoded by said nucleic acid or nucleic acids comprise a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 522 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 542;   (1ii) the variable heavy and light chains encoded by said nucleic acid or nucleic acids are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 522 and SEQ ID NO: 542, respectively;   (1iii) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 562 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 582;   (1iv) the variable heavy and light chains encoded by said nucleic acid or nucleic acids are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 562 and SEQ ID NO: 582, respectively;   (1v) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 602 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 622;   (1vi) the variable heavy and light chains encoded by said nucleic acid or nucleic acids are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 602 and SEQ ID NO: 622, respectively;   (1vii) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 642 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 662;   (1xviii) the variable heavy and light chains encoded by said nucleic acid or nucleic acids are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 642 and SEQ ID NO: 662, respectively;   (1ix) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 682 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 702;   (1x) the variable heavy and light chains encoded by said nucleic acid or nucleic acids are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 682 and SEQ ID NO: 702, respectively;   (1xi) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 722 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 742;   (1xii) the variable heavy and light chains encoded by said nucleic acid or nucleic acids are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 722 and SEQ ID NO: 742, respectively;   (1xiii) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 762 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 782;   (1xiv) the variable heavy and light chains encoded by said nucleic acid or nucleic acids are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 762 and SEQ ID NO: 782, respectively;   (1xv) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 802 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 822;   (1xvi) the variable heavy and light chains encoded by said nucleic acid or nucleic acids are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 802 and SEQ ID NO: 822, respectively;   (1xvii) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 842 and the variable light chain encoded by said nucleic acid or nucleic acids comprises s a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 862;   (1xviii) the variable heavy and light chains are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 842 and SEQ ID NO: 862, respectively;   (1xix) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 882 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 902;   (1xx) the variable heavy and light chains encoded by said nucleic acid or nucleic acids are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 882 and SEQ ID NO: 902, respectively;   (1xxi) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 922 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 942;   (1xxii) the variable heavy and light chains encoded by said nucleic acid or nucleic acids are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 922 and SEQ ID NO: 942, respectively;   (1xxiii) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 962 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 982;   (1xxiv) the variable heavy and light chains encoded by said nucleic acid or nucleic acids are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 962 and SEQ ID NO: 982, respectively;   (1xxv) the variable heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 1002 and the variable light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 1022;   (1xxvi) the variable heavy and light chains encoded by said nucleic acid or nucleic acids are each at least 90% identical to the variable heavy and light chains in SEQ ID NO: 1002 and SEQ ID NO: 1022, respectively;   (1xxvii) the heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 1 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 21;   (1xxviii) the heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 41 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 61;   (1xxix) the heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence is at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 81 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 101;   (1xxx) the heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 121 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 141;   (1xxxi) the heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 161 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 181;   (1xxxii) the heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 201 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 221;   (1xxxiii) the heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 241 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 261;   (1xxxiv) the heavy chain encoded by said nucleic acid or nucleic acids comprises SEQ ID NO: 321 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 341;   (1xxxv) heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 361 and the light chain encoded by said nucleic acid or nucleic acids comprises SEQ ID NO: 381;   (1xxxvi) the heavy chain encoded by said nucleic acid or nucleic acids comprises SEQ ID NO: 401 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 421;   (1xxxvii) the heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 441 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 461;   (1xxxviii) the heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 481 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 501;   (1xxxix) the heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 521 and the light chain encoded by said nucleic acid or nucleic acids comprises SEQ ID NO: 541;   (1xxxx) the heavy chain encoded by said nucleic acid or nucleic acids comprises SEQ ID NO: 561 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 581;   (1xxxxi) the heavy chain encoded by said nucleic acid or nucleic acids a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 601 and the light chain encoded by said nucleic acid or nucleic acids comprises SEQ ID NO: 621;   (1xxxxii) the heavy chain encoded by said nucleic acid or nucleic acids comprises SEQ ID NO: 641 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 661;   (1xxxxiii) the heavy chain encoded by said nucleic acid or nucleic acids comprises s a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 681 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 701;   (1xxxxiv) the heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 721 and the light chain encoded by said nucleic acid or nucleic acids comprises SEQ ID NO: 741;   (1xxxxv) the heavy chain encoded by said nucleic acid or nucleic acids comprises SEQ ID NO: 761 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 781;   (1xxxxvi) the heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence that is at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 801 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 821;   (1xxxxvii) the heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence that is at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 841 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 861;   (1xxxxviii) the heavy chain encoded by said nucleic acid or nucleic acids comprises a sequence that is at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 881 and the light chain encoded by said nucleic acid or nucleic acids comprises SEQ ID NO: 901;   (1xxxxix) the heavy chain encoded by said nucleic acid or nucleic acids comprises SEQ ID NO: 921 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 941;   (c) the heavy chain encoded by said nucleic acid or nucleic acids comprises SEQ ID NO: 961 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 981; and   (ci) the heavy chain encoded by said nucleic acid or nucleic acids comprises SEQ ID NO: 1001 and the light chain encoded by said nucleic acid or nucleic acids comprises a sequence at least 80, 85, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 1021; and/or any combination of the foregoing.   
     
     
         349 . The nucleic acid or nucleic acids of  claim 348  wherein the antibody or antibody fragment encoded by said nucleic acid or nucleic acids is selected from:
 (i) chimeric, humanized, and human antibodies or antibody fragments; 
 (ii) scFvs, camelbodies, nanobodies, IgNAR, Fab fragments, Fab′ fragments, MetMabs, monovalent antibody fragments, and F(ab′)2 fragments; 
 (iii) the expressed antibody or antibody fragment encoded by said nucleic acid or nucleic acids substantially or entirely lacks N-glycosylation and/or O-glycosylation; 
 (iv) the expressed antibody or antibody fragment encoded by said nucleic acid or nucleic acids comprises a human constant domain; 
 (v) the expressed antibody encoded by said nucleic acid or nucleic acids is an IgG1, IgG2, IgG3, or IgG4 antibody; 
 (vi) said nucleic acid or nucleic acids comprise a sequence encoding a VH and a VL region at least 80, 90, 95, 96, 97, 98, 99 or 100% identical to SEQ ID NO: 12, SEQ ID NO: 32; SEQ ID NO: 52, SEQ ID NO: 72; SEQ ID NO: 92, SEQ ID NO: 112; SEQ ID NO: 132, SEQ ID NO: 152; SEQ ID NO: 172, SEQ ID NO: 192; SEQ ID NO: 212, SEQ ID NO: 232, SEQ ID NO: 252, SEQ ID NO: 272; SEQ ID NO: 332, SEQ ID NO: 352; SEQ ID NO: 372, SEQ ID NO: 392; SEQ ID NO: 412, SEQ ID NO: 432; SEQ ID NO: 452, SEQ ID NO: 472; SEQ ID NO: 492, SEQ ID NO: 512, SEQ ID NO: 532, SEQ ID NO: 552, SEQ ID NO: 572, SEQ ID NO: 592, SEQ ID NO: 612, SEQ ID NO: 632, SEQ ID NO: 652, SEQ ID NO: 672; SEQ ID NO: 692; SEQ ID NO: 712; SEQ ID NO: 732; SEQ ID NO: 752; SEQ ID NO: 772; SEQ ID NO: 792; SEQ ID NO: 812; SEQ ID NO: 832; SEQ ID NO: 852; SEQ ID NO: 872; SEQ ID NO: 892; SEQ ID NO: 912; SEQ ID NO: 932; SEQ ID NO: 952; SEQ ID NO:972, SEQ ID NO:992; SEQ ID NO:1012, SEQ ID NO:1032; or a codon degenerate of any of the foregoing; and/or 
 (vii) the nucleic acid sequence or sequences comprise  Pichia  or human preferred codons. 
 
     
     
         350 . A vector or vectors or host cell or cells comprising the nucleic acid sequence or sequences of  claim 349 . 
     
     
         351 . The host cell of  claim 350 , wherein said host cell is a mammalian, bacterial, fungal, yeast, avian or insect cell. 
     
     
         352 . The host cell of  claim 350 , which comprises:
 (i) a filamentous fungi or a yeast;   (ii) a filamentous fungi or yeast selected from  Pichia pastoris, Pichia finlandica, Pichia trehalophila, Pichia koclamae, Pichia membranaefaciens, Pichia minuta  ( Ogataea minuta, Pichia lindneri ),  Pichia opuntiae, Pichia thermotolerans, Pichia salictaria, Pichia guercuum, Pichia pijperi, Pichia stiptis, Pichia methanolica, Pichia  sp.,  Saccharomyces cerevisiae, Saccharomyces  sp.,  Hansenula polymorpha, Kluyveromyces  sp.,  Kluyveromyces lactis, Candida albicans, Aspergillus nidulans, Aspergillus niger, Aspergillus oryzae, Trichoderma reesei, Chrysosporium lucknowense, Fusarium  sp.,  Fusarium gramineum, Fusarium venenatum, Physcomitrella patens Neurospora crassa, Pichia  sp., any  Saccharomyces  sp.,  Hansenula polymorpha , any  Kluyveromyces  sp.,  Candida albicans , any  Aspergillus  sp.,  Trichoderma reesei, Chrysosporium lucknowense , any  Fusarium  sp. and  Neurospora crassa;      (iii) a mammalian cell; and/or   (iv) a CHO, COS, BHK, myeloma, monkey kidney CV1 line transformed by SV40 (COS-7, ATCC CRL 1651); human embryonic kidney line (293 or 293 cells subcloned for growth in suspension culture), mouse sertoli cell; human lung cell; human liver cell, or a mouse mammary tumor cell.   
     
     
         353 . A method of making the antibody or antibody fragment according to  claim 343 , by expressing nucleic acids which encode for the expression of said antibody or antibody fragment in a recombinant host cell. 
     
     
         354 . The method of  claim 353  wherein the host cell is selected from:
 (i) a bacteria, yeast, fungi, insect cell, plant cell, avian cell, or mammalian cell; 
 (ii) s a yeast or a filamentous fungi, which may optionally be polyploidal; 
 (iii) a yeast or fungi selected from  Pichia pastoris, Pichia finlandica, Pichia trehalophila, Pichia koclamae, Pichia membranaefaciens, Pichia minuta  ( Ogataea minuta, Pichia lindneri ),  Pichia opuntiae, Pichia thermotolerans, Pichia salictaria, Pichia guercuum, Pichia pijperi, Pichia stiptis, Pichia methanolica, Pichia  sp.,  Saccharomyces cerevisiae, Saccharomyces  sp.,  Hansenula polymorpha, Kluyveromyces  sp.,  Kluyveromyces lactis, Candida albicans, Aspergillus nidulans, Aspergillus niger, Aspergillus oryzae, Trichoderma reesei, Chrysosporium lucknowense, Fusarium  sp.,  Fusarium gramineum, Fusarium venenatum, Physcomitrella patens  and  Neurospora crassa, Pichia  sp., any  Saccharomyces  sp.,  Hansenula polymorpha , any  Kluyveromyces  sp.,  Candida albicans , any  Aspergillus  sp.,  Trichoderma reesei, Chrysosporium lucknowense , any  Fusarium  sp. and  Neurospora crassa;    
 (iv) a mammalian cell; 
 (v) a CHO, COS, BHK, myeloma, monkey kidney CV1 line transformed by SV40 (COS-7, ATCC CRL 1651); human embryonic kidney line (293 or 293 cells subcloned for growth in suspension culture), mouse sertoli cell; human lung cell; human liver cell, or a mouse mammary tumor cell; or 
 (vi) a CHO cell. 
 
     
     
         355 . The method of  claim 354 , wherein said host cell is a polyploidal  Pichia  yeast which is made by a method that comprises:
 (A) introducing at least one expression vector containing one or more heterologous polynucleotides encoding said antibody operably linked to a promoter and a signal sequence into a haploid yeast cell;   (B) producing by mating or spheroplast fusion a polyploidal yeast from said first and/or second haploid yeast cell;   (C) selecting polyploidal yeast cells that stably express said antibody; and   (D) producing stable polyploidal yeast cultures from said polyploidal yeast cells that      
     
     
         356 . A method of treatment or diagnosis, wherein said method comprises the administration of at least one anti-HGF antibody or antibody fragment according to  claim 343  or a composition containing, wherein said method comprises:
 (i) administering to a patient with a disease or condition associated with HGF expressing cells or the overexpression of HGF a therapeutically or prophylactically or diagnostically effective amount of said anti-human HGF antibody or fragment or composition containing; 
 (ii) modulating (inhibiting, blocking or promoting) HGF-associated angiogenesis in a subject in need thereof comprising administering a therapeutically or prophylactically effective amount of at least one anti-human HGF antibody or fragment or composition containing; 
 (iii) modulating (inhibiting, blocking or promoting) HGF-associated cell proliferation in a subject in need thereof comprising administering a therapeutically or prophylactically effective amount of at least one anti-human HGF antibody or fragment or composition containing; 
 (iv) modulating (inhibiting, blocking or promoting) HGF-associated cell invasion in a subject in need thereof comprising administering a therapeutically or prophylactically effective amount of at least one anti-human HGF antibody or fragment or composition containing; 
 (v) inhibiting or blocking HGF-associated metastasis in a subject in need thereof comprising administering a therapeutically or prophylactically effective amount of at least one anti-human HGF antibody or fragment or composition containing; 
 (vi) modulating (inhibiting, blocking or promoting) the HGF/HGF-R (c-met) interaction and/or c-met activation in a subject in need thereof comprising administering a therapeutically or prophylactically effective amount of at least one anti-human HGF antibody or fragment or composition containing; 
 (vii) inhibiting or blocking the mitogenic, motogenic, and/or morphogenic properties of HGF in a subject in need thereof comprising administering a therapeutically or prophylactically effective amount of at least one anti-human HGF antibody or fragment or composition containing; 
 (viii) promoting HGF-associated fibrosis in a subject in need thereof comprising administering a therapeutically or prophylactically effective amount of at least one anti-human HGF antibody or fragment or composition containing; and/or 
 (ix) inhibiting HGF-associated cell scattering in a subject in need thereof comprising administering a therapeutically or prophylactically effective amount of at least one anti-human HGF antibody or fragment or composition containing, or any combination thereof. 
 
     
     
         357 . A method according to  claim 356 , wherein
 (i) said antibody or fragment inhibits or prevents HGF/c-met binding;   (ii) said antibody or fragment does not inhibit or prevent HGF/c-met binding;   (iii) said antibody or fragment inhibits c-met activation;   (iv) said antibody or fragment binds to HGF/HGF-R complexes or multimers.   
     
     
         358 . A method according to  claim 356  wherein said method includes administration of another therapeutic agent. 
     
     
         359 . The method of  claim 358  wherein the other therapeutic agent is selected from: chemotherapy agents, statins, cytokines, immunosuppressive agents, gene therapy agents, anti-coagulants, anti-cachexia agents, anti-weakness agent, anti-fatigue agent, anti-fever agent, anti-nausea agents, antiemetic agents, IL-6 antagonists, cytotoxic agents, analgesics, antipyretics, anti-inflammatory agents, antibiotics, antiviral agents, anti-cytokine agents, anti-angiogenesis agents, or any combination thereof. 
     
     
         360 . The method of  claim 359 , wherein:
 (i) the chemotherapy agent is selected from: VEGF antagonists, EGFR antagonists, platins, taxols, irinotecan, 5-fluorouracil, gemcitabine, leucovorin, steroids, cyclophosphamide, melphalan, vinca alkaloids, vinblastine, vincristine, vindesine, vinorelbine, mustines, tyrosine kinase inhibitors, radiotherapy, sex hormone antagonists, selective androgen receptor modulators, selective estrogen receptor modulators, PDGF antagonists, TNF antagonists, IL-I antagonists, interleukins, IL-12, IL-2, IL-12R antagonists, Toxin conjugated monoclonal antibodies, tumor antigen specific monoclonal antibodies, Erbitux™, Avastin™, Pertuzumab, anti-CD20 antibodies, Rituxan®, ocrelizumab, ofatumumab, DXL625, Herceptin®, or any combination thereof;   (ii) the anti-coagulant is selected from abciximab (ReoPro™), acenocoumarol, antithrombin IE, argatroban, aspirin, bivalirudin (Angiomax™), clopidogrel, dabigatran, dabigatran etexilate (Pradaxa™/Pradax™), desirudin (Revasc™/Iprivask™), dipyridamole, eptifibatide (Integrilin™), fondaparinux, heparin, hirudin, idraparinux, lepirudin (Refludan™) low molecular weight heparin, melagatran, phenindione, phenprocoumon, ticlopidine, tirofiban (Aggrastat™), warfarin, ximelagatran, ximelagatran (Exanta™/Exarta™), or any combination thereof;   (iii) the statin is selected from: atorvastatin, cerivastatin, fluvastatin, lovastatin, mevastatin, pravastatin, pravastatin, rosuvastatin, simvastatin, or any combination thereof;   (iv) the another therapeutic agent is an antagonist of a factor selected from tumor necrosis factor-alpha, Interferon gamma, Interleukin 1 alpha, Interleukin 1 beta, Interleukin 6, proteolysis inducing factor, leukemia-inhibitory factor, or any combination thereof;   (v) the another therapeutic agent is an anti-angiogenesis factor selected from soluble VEGFR-1, NRP-1, Angiopoietin 2, TSP-1 and TSP-2, angiostatin and related molecules, endostatin, vasostatin, calreticulin, platelet factor-4, TIMP, CDAI, Meth-1, Meth-2, IFN-α, -β and -γ, CXCL10, IL-4, -12 and -18, prothrombin (kringle domain-2), antithrombin III fragment, prolactin, VEGI, SPARC, osteopontin, maspin, and canstatin;   (vi) the other therapeutic agent is an anti-cachexia agent comprising:  cannabis , dronabinol (Marinol™), nabilone (Cesamet), cannabidiol, cannabichromene, tetrahydrocannabinol, Sativex, megestrol acetate, or any combination thereof;   (vii) the other therapeutic agent is an anti-nausea agent or antiemetic agent is comprising: 5-HT3 receptor antagonists, ajwain, alizapride, anticholinergics, antihistamines, aprepitant, benzodiazepines, cannabichromene, cannabidiol, cannabinoids,  cannabis , casopitant, chlorpromazine, cyclizine, dexamethasone, dexamethasone, dimenhydrinate (Gravol™) diphenhydramine, dolasetron, domperidone, dopamine antagonists, doxylamine, dronabinol (Marinol™), droperidol, emetrol, ginger, granisetron, haloperidol, hydroxyzine, hyoscine, lorazepam, meclizine, metoclopramide, midazolam, muscimol, nabilone (Cesamet), nk1 receptor antagonists, ondansetron, palonosetron, peppermint, Phenergan, prochlorperazine, Promacot, promethazine, Pentazine, propofol, sativex, tetrahydrocannabinol, trimethobenzamide, tropisetron, nandrolone, stilbestrol, thalidomide, lenalidomide, ghrelin agonists, myostatin antagonists, anti-myostatin antibodies, selective androgen receptor modulators, selective estrogen receptor modulators, angiotensin All antagonists, beta two adrenergic receptor agonists, beta three adrenergic receptor agonists, or any combination thereof;   (viii) the other therapeutic agent comprises tamoxifen, BCL-2 antagonists, estrogen, bisphosphonates, teriparatide, strontium ranelate, sodium alendronate (Fosamax), risedronate (Actonel), raloxifene, ibandronate (Boniva), Obatoclax, ABT-263, gossypol, gefitinib, epidermal growth factor receptor tyrosine kinase inhibitors, erlotinib, epidermal growth factor receptor inhibitors, psoralens, trioxsalen, methoxsalen, bergapten, retinoids, etretinate, acitretin, infliximab (Remicade®), adalimumab, infliximab, etanercept, Zenapax™, Cyclosporine, Methotrexate, granulocyte-colony stimulating factor, filgrastim, lenograstim, Neupogen, Neulasta, 2-Arylpropionic acids, Aceclofenac, Acemetacin, Acetylsalicylic acid (Aspirin), Alclofenac, Alminoprofen, Amoxiprin, Ampyrone, Arylalkanoic acids, Azapropazone, Benorylate/Benorilate, Benoxaprofen, Bromfenac, Carprofen, Celecoxib, Choline magnesium salicylate, Clofezone, COX-2 inhibitors, Dexibuprofen, Dexketoprofen, Diclofenac, Diflunisal, Droxicam, Ethenzamide, Etodolac, Etoricoxib, Faislamine, fenamic acids, Fenbufen, Fenoprofen, Flufenamic acid, Flunoxaprofen, Flurbiprofen, Ibuprofen, Ibuproxam, Indometacin, Indoprofen, Kebuzone, Ketoprofen, Ketorolac, Lornoxicam, Loxoprofen, Lumiracoxib, Magnesium salicylate, Meclofenamic acid, Mefenamic acid, Meloxicam, Metamizole, Methyl salicylate, Mofebutazone, Nabumetone, Naproxen, N-Arylanthranilic acids, Oxametacin, Oxaprozin, Oxicams, Oxyphenbutazone, Parecoxib, Phenazone, Phenylbutazone, Phenylbutazone, Piroxicam, Pirprofen, profens, Proglumetacin, Pyrazolidine derivatives, Rofecoxib, Salicyl salicylate, Salicylamide, Salicylates, Sulfinpyrazone, Sulindac, Suprofen, Tenoxicam, Tiaprofenic acid, Tolfenamic acid, Tolmetin, and Valdecoxib, Antibiotics, Amikacin, Aminoglycosides, Amoxicillin, Ampicillin, Ansamycins, Arsphenamine, Azithromycin, Azlocillin, Aztreonam, Bacitracin, Carbacephem, Carbapenems, Carbenicillin, Cefaclor, Cefadroxil, Cefalexin, Cefalothin, Cefalotin, Cefamandole, Cefazolin, Cefdinir, Cefditoren, Cefepime, Cefixime, Cefoperazone, Cefotaxime, Cefoxitin, Cefpodoxime, Cefprozil, Ceftazidime, Ceftibuten, Ceftizoxime, Ceftobiprole, Ceftriaxone, Cefuroxime, Cephalosporins, Chloramphenicol, Cilastatin, Ciprofloxacin, Clarithromycin, Clindamycin, Cloxacillin, Colistin, Co-trimoxazole, Dalfopristin, Demeclocycline, Dicloxacillin, Dirithromycin, Doripenem, Doxycycline, Enoxacin, Ertapenem, Erythromycin, Ethambutol, Flucloxacillin, Fosfomycin, Furazolidone, Fusidic acid, Gatifloxacin, Geldanamycin, Gentamicin, Glycopeptides, Herbimycin, Imipenem, Isoniazid, Kanamycin, Levofloxacin, Lincomycin, Linezolid, Lomefloxacin, Loracarbef, Macrolides, Mafenide, Meropenem, Meticillin, Metronidazole, Mezlocillin, Minocycline, Monobactams, Moxifloxacin, Mupirocin, Nafcillin, Neomycin, Netilmicin, Nitrofurantoin, Norfloxacin, Ofloxacin, Oxacillin, Oxytetracycline, Paromomycin, Penicillin, Penicillins, Piperacillin, Platensimycin, Polymyxin B, Polypeptides, Prontosil, Pyrazinamide, Quinolones, Quinupristin, Rifampicin, Rifampin, Roxithromycin, Spectinomycin, Streptomycin, Sulfacetamide, Sulfamethizole, Sulfanamide, Sulfasalazine, Sulfisoxazole, Sulfonamides, Teicoplanin, Telithromycin, Tetracycline, Tetracyclines, Ticarcillin, Tinidazole, Tobramycin, Trimethoprim, Trimethoprim-Sulfamethoxazole, Troleandomycin, Trovafloxacin, Vancomycin; Aldosterone, Beclometasone, Betamethasone, Corticosteroids, Cortisol, Cortisone acetate, Deoxycorticosterone acetate, Dexamethasone, Fludrocortisone acetate, Glucocorticoids, Hydrocortisone, Methylprednisolone, Prednisolone, Prednisone, Steroids, and Triamcinolone; Antiviral agents including by way of example abacavir, acyclovir, adefovir, amantadine, amprenavir, an antiretroviral fixed dose combination, an antiretroviral synergistic enhancer, arbidol, atazanavir, atripla, brivudine, cidofovir, combivir, darunavir, delavirdine, didanosine, docosanol, edoxudine, efavirenz, emtricitabine, enfuvirtide, entecavir, entry inhibitors, famciclovir, fomivirsen, fosamprenavir, foscarnet, fosfonet, fusion inhibitor, ganciclovir, gardasil, ibacitabine, idoxuridine, imiquimod, imunovir, indinavir, inosine, integrase inhibitor, interferon, interferon type I, interferon type II, interferon type III, lamivudine, lopinavir, loviride, maraviroc, MK-0518, moroxydine, nelfinavir, nevirapine, nexavir, nucleoside analogues, oseltamivir, penciclovir, peramivir, pleconaril, podophyllotoxin, protease inhibitor, reverse transcriptase inhibitor, ribavirin, rimantadine, ritonavir, saquinavir, stavudine, tenofovir, tenofovir disoproxil, tipranavir, trifluridine, trizivir, tromantadine, truvada, valaciclovir, valganciclovir, vicriviroc, vidarabine, viramidine, zalcitabine, zanamivir, zidovudine, or any combination thereof;   (ix) the other therapeutic agent is selected from a cytotoxic agent, chemotherapeutic agent, or immunosuppressive agent is comprising: 1-dehydrotestosterone, 1-methylnitrosourea, 5-fluorouracil, 6-mercaptopurine, 6-mercaptopurine, 6-thioguanine, Abatacept, abraxane, acitretin, aclarubicin, Actinium-225 ( 225 Ac), actinomycin, Adalimumab, adenosine deaminase inhibitors, Afelimomab, Aflibercept, Afutuzumab, Alefacept, alitretinoin, alkyl sulfonates, alkylating agents, altretamine, alvocidib, aminolevulinic acid/methyl aminolevulinate, aminopterin, aminopterin, amrubicin, amsacrine, amsacrine, anagrelide, Anakinra, anthracenediones, anthracyclines, anthracyclines, anthracyclines, anthramycin (AMC); antimytotic agents, antibiotics, anti-CD20 antibodies, antifolates, Anti-lymphocyte globulin, Antimetabolites, Anti-thymocyte globulin, arsenic trioxide, Aselizumab, asparaginase, asparagine depleters, Astatine-211 ( 211 At), Atlizumab, Atorolimumab, atrasentan, Avastin™ azacitidine, Azathioprine, azelastine, aziridines, Basiliximab, BAYX antibodies, Belatacept, Belimumab, belotecan, bendamustine, Bertilimumab, bexarotene, bisantrene, Bismuth-213 ( 213 Bi), Bismuth-212 ( 212 Bi), bleomycin, bleomycin, bleomycin, BLyS antibodies, bortezomib, busulfan, busulfan, Calcineurin inhibitors, calicheamicin, camptothecin, camptothecins, capecitabine, carboplatin (paraplatin), carboquone, carminomycin, carmofur, carmustine, carmustine (BSNU), CAT antibodies, CD11a antibodies, CD147/Basigin antibodies, CD154 antibodies, CD18 antibodies, CD20 antibodies, CD23 antibodies, CD3 antibodies, CD4 antibodies, CD40 antibodies, CD62L/L-selectin antibodies, CD80 antibodies, CDK inhibitors, Cedelizumab, celecoxib, Certolizumab pegol, chlorambucil, chlorambucils, Ciclosporin, cis-dichlorodiamine platinum (II) (DDP) cisplatin, cladribine, Clenoliximab, clofarabine, colchicin, Complement component 5 antibodies, Copper-67 (67Cu), corticosteroids, CTLA-4 antibodies, CTLA-4 fusion proteins, Cyclophilin inhibitors, cyclophosphamides, cyclothosphamide, cytarabine, cytarabine, cytochalasin B, cytotoxic ribonucleases, dacarbazine, Daclizumab, dactinomycin, dactinomycin (actinomycin D), daunorubicin, daunorubicin, daunorubicin (formerly daunomycin), decitabine, Deforolimus, demecolcine, detorubicin, dibromomannitol, diethylcarbamazine, dihydrofolate reductase inhibitors, dihydroxy anthracin dione, diphtheria toxin, DNA polymerase inhibitors, docetaxel, Dorlimomab aritox, Dorlixizumab, doxorubicin (adriamycin), DXL625, Eculizumab, Efalizumab, efaproxiral, EGFR antagonists, elesclomol, elsamitrucin, Elsilimomab, emetine, endothelin receptor antagonists, epipodophyllotoxins, epirubicin, epothilones, Erbitux™, Erlizumab, estramustine, Etanercept, ethidium bromide, etoglucid, etoposide, etoposide phosphate, Everolimus, Faralimomab, farnesyltransferase inhibitors, FKBP inhibitors, floxuridine, fludarabine, fluorouracil, Fontolizumab, fotemustine, Galiximab, Gallium-67 (67Ga), Gantenerumab, Gavilimomab, gemcitabine, glucocorticoids, Golimumab, Gomiliximab, gramicidin D, Gusperimus, Herceptin®, hydrazines, hydroxyurea, hypomethylating agents, idarubicin, Idarubicine, ifosfamide, IL-I antagonists, IL-I receptor antagonists, IL-12, IL-12 antibodies, IL-12R antagonists, IL-13 antibodies, IL-2, IL-2 inhibitors, IL-2 receptor/CD25 antibodies, IL-6 antibodies, imatinib mesylate, Immunoglobulin E antibodies, IMP dehydrogenase inhibitors, Infliximab, Inolimomab, Integrin antibodies, Interferon antibodies, interferons, Interleukin 5 antibodies, Interleukin-6 receptor antibodies, interleukins, Iodine-125 ( 125 I), Iodine-131 (131I), Ipilimumab, irinotecan, ixabepilone, Keliximab, larotaxel, Lead-212 ( 212 Pb), Lebrilizumab, Leflunomide, Lenalidomide, Lerdelimumab, leucovorine, LFA-I antibodies, lidocaine, lipoxygenase inhibitors, lomustine (CCNU), lonidamine, lucanthone, Lumiliximab, Lutetium-177 ( 177 Lu), Macrolides, mannosulfan, Maslimomab, masoprocol, mechlorethamine, melphalan, Mepolizumab, mercaptopurine, Metelimumab, Methotrexate, microtubule assembly inhibitors, microtubule stability enhancers, mithramycin, mitobronitol, mitoguazone, mitomycin, mitomycin C, mitotane, mitoxantrone, Morolimumab, mTOR inhibitors, Muromonab-CD3, mustines, Mycophenolic acid, mytotane (O,P′-(DDD)), Natalizumab, nedaplatin, Nerelimomab, nimustine, nitrogen mustards, nitrosoureas, nordihydroguaiaretic acid, oblimersen, ocrelizumab, Ocrelizumab, Odulimomab, ofatumumab, olaparib, Omalizumab, ortataxel, Otelixizumab, oxaliplatin, oxaliplatin, paclitaxel (taxol), Pascolizumab, PDGF antagonists, pegaspargase, pemetrexed, Pentostatin, Pertuzumab, Pexelizumab, phosphodiesterase inhibitors, Phosphorus-32 ( 32 P), Pimecrolimus Abetimus, pirarubicin, pixantrone, platins, plicamycin, poly ADP ribose polymerase inhibitors, porfimer sodium, porphyrin derivatives, prednimustine, procaine, procarbazine, procarbazine, propranolol, proteasome inhibitors,  pseudomonas  exotoxin,  Pseudomonas  toxin, purine synthesis inhibitors, puromycin, pyrimidine synthesis inhibitors, radionuclides, radiotherapy, raltitrexed, ranimustine, Reslizumab, retinoid X receptor agonists, retinoids, Rhenium-186 ( 186 Re), Rhenium-188 ( 188 Re), ribonucleotide reductase inhibitors, ricin, Rilonacept, Rituxan®, Rovelizumab, rubitecan, Ruplizumab, Samarium-153 ( 153 Sm), satraplatin, Scandium-47 ( 47 Sc), selective androgen receptor modulators, selective estrogen receptor modulators, seliciclib, semustine, sex hormone antagonists, Siplizumab, Sirolimus, steroid aromatase inhibitors, steroids, streptozocin, streptozotocin, Tacrolimus, talaporfin, Talizumab, taxanes, taxols, tegafur, Telimomab aritox, temoporfin, temozolomide, temsirolimus, Temsirolimus, Teneliximab, teniposide, Teplizumab, Teriflunomide, tesetaxel, testolactone, tetracaine, Thalidomide, thioepa chlorambucil, thiopurines thioguanine, ThioTEPA, thymidylate synthase inhibitors, tiazofurin, tipifarnib, T-lymphocyte antibodies, TNF antagonists, TNF antibodies, TNF fusion proteins, TNF receptor fusion proteins, TNF-alpha inhibitors, Tocilizumab, topoisomerase inhibitors, topotecan, Toralizumab, trabectedin, Tremelimumab, treosulfan, tretinoin, triazenes, triaziquone, triethylenemelamine, triplatin tetranitrate, trofosfamide, tumor antigen specific monoclonal antibodies, tyrosine kinase inhibitors, uramustine, Ustekinumab, valrubicin, Valrubicine, Vapaliximab, VEGF antagonists, Vepalimomab, verteporfin, vinblastine, vinca alkaloids, vincristine, vindesine, vinflunine, vinorelbine, Visilizumab, vorinostat, Yttrium-88 ( 88 Y), Yttrium-90 ( 90 Y), Zanolimumab, zileuton, Ziralimumab, Zolimomab aritox, zorubicin, Zotarolimus, or any combination thereof; and/or   (x) the another active agent is one or more agonist, antagonist, or modulator of a factor comprising: TNF-alpha, IL-2, IL-4, IL-6, IL-10, IL-12, IL-13, IL-18, IFN-alpha, WN-gamma, BAFF, CXCL13, IP-10, VEGF, EPO, EGF, HRG, Hepatocyte Growth Factor (HGF), Hepcidin, or any combination of (i) through (ix).