Antioxidant dietary supplement and related method

Abstract

A supplement including a blend of turmeric, quercetin and rosemary, or holy basil, wasabi, and broccoli seed extract which are present in a balanced and predetermined ratio, and which stimulate the Antioxidant Response Element (ARE), Quinone Reductase, and/or induce related gene expression, for example, heme oxygenase-1 (HMOX-1) expression. The blend of ingredients can be formed as or in a dietary supplement adapted for administration to a subject. The dietary supplement can be formulated so that the turmeric, quercetin and rosemary are present in a predetermined ratio of 1:3:5, or holy basil, wasabi, and broccoli seed extract in a predetermined ratio of 1:1:0.2. Additional ingredients can be included in the supplement. The supplement can synergistically affect natural antioxidant response pathways within cells of a subject to whom the supplement is administered. A related method of use is also provided.

1 - 11 . (canceled) 
     
     
         12 . A dietary supplement comprising:
 holy basil;   wasabi; and   broccoli seed extract;   wherein the holy basil, wasabi, and broccoli seed extract are present in the supplement in a ratio of 1:1:0.2, respectively; and   wherein the holy basil, wasabi, and broccoli seed extract cooperate to at least one of stimulate a Quinone Reductase production and induce Heme Oxygenase-1 (HMOX-1) expression when the supplement is administered to a subject.   
     
     
         13 . The dietary supplement of  claim 12 , wherein the holy basil, wasabi, and broccoli seed extract are present in the supplement in an amount of 136 mg, 136 mg, and 28 mg, respectively. 
     
     
         14 . The dietary supplement of  claim 12 , wherein the holy basil, wasabi, and broccoli seed extract are present in the supplement in an amount of 273 mg, 273 mg, and 54 mg, respectively. 
     
     
         15 . A blend for inclusion in a dietary supplement, the blend consisting of holy basil, wasabi, and broccoli seed extract, wherein the holy basil, wasabi, and broccoli seed extract are each present in the supplement in an amount and in a ratio sufficient to at least one of stimulate Quinone Reductase activity and induce Heme Oxygenase-1 (HMOX-1) expression when the supplement is administered to a subject. 
     
     
         16 . The blend of  claim 15 , wherein the holy basil, wasabi, and broccoli seed extract are present in the supplement in a ratio of 1:1:0.2, respectively. 
     
     
         17 . The blend of  claim 15 , wherein the holy basil, wasabi, and broccoli seed extract are present in a ratio sufficient to decrease a urinary level of 8-isoprostane in a human. 
     
     
         18 . The blend of  claim 15 , wherein the holy basil, wasabi, and broccoli seed extract are present in a ratio sufficient to increase production of Superoxide dismutase in a human. 
     
     
         19 . A method of supplementing a human diet comprising:
 providing a dietary supplement including holy basil, wasabi, and broccoli seed extract, wherein the holy basil, wasabi, and broccoli seed extract are present in the supplement in a ratio of 1:1:0.2, respectively; and   orally administering the dietary supplement to a human so as to at least one of stimulate Quinone Reductase activity and induce Heme Oxygenase-1 (HMOX-1) expression in cells of the human.   
     
     
         20 . The method of  claim 19 , wherein the holy basil, wasabi, and broccoli seed extract are included in at least one of a capsule, tablet, and liquid form for oral administration to the subject. 
     
     
         21 . The dietary supplement of  claim 12 , wherein the holy basil is at least one of derived and extracted from  Ocimum sanctum.    
     
     
         22 . The dietary supplement of  claim 12 , wherein the wasabi is derived from  Wasabia japonica.    
     
     
         23 . The dietary supplement of  claim 12 , wherein the broccoli seed extract is extracted from  Brassica oleracea italica.    
     
     
         24 . The dietary supplement of  claim 12 , further comprising at least one of vitamins and minerals. 
     
     
         25 . The dietary supplement of  claim 12 , further comprising at least one of flavors, excipients, binders, protein, complex carbohydrates, preservatives, and chelating agents. 
     
     
         26 . The dietary supplement of  claim 12 , wherein the supplement is in the form of a capsule, a tablet, a powder, a gel, or a liquid.