Therapies for hematologic malignancies

Abstract

The invention provides methods that relate to a novel therapeutic strategy for the treatment of hematological malignancies and inflammatory diseases. In particular, the method comprises administering a compound of formula A, wherein R is H, halo, or C1-C6 alkyl; R′ is C1-C6 alkyl; or a pharmaceutically acceptable salt thereof; and optionally a pharmaceutically acceptable excipient; and administering at least one additional therapeutic agent.

1 . A method to treat a condition, wherein the condition is cancer or an autoimmune condition, comprising administering to a subject in need of such treatment, an effective amount of a compound having a formula A, 
       
         
           
           
               
               
           
         
         wherein R is H, halo, or C1-C6 alkyl; 
         R′ is C1-C6 alkyl; or 
         a pharmaceutically acceptable salt thereof; and 
         optionally a pharmaceutically acceptable excipient.