US2019083464A1PendingUtilityA1

Systems and methods to treat pain locally

72
Assignee: WARSAW ORTHOPEDIC INCPriority: Jul 26, 2006Filed: Nov 8, 2018Published: Mar 21, 2019
Est. expiryJul 26, 2026(expired)· nominal 20-yr term from priority
Inventors:Eric BurrightLisa Lynn ShaferWilliam F. MckayJohn M. Zanella
A61K 31/381A61K 9/0019A61K 31/498A61K 31/366A61K 31/00A61K 31/185A61K 31/401A61P 25/04A61K 9/1647A61K 31/4402A61M 5/14276A61M 37/0069A61K 31/4168A61K 9/0024A61P 25/02A61K 9/0085A61M 5/14244G01N 2800/2842A61P 29/00A61K 31/352A61K 31/192
72
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Claims

Abstract

Disclosed herein are systems and methods for contributing to the local treatment of pain. More specifically, the disclosed systems and methods contribute to the local treatment of pain by inhibiting the NFκB family of transcription factors.

Claims

exact text as granted — not AI-modified
1 . (canceled) 
     
     
         2 . A method of treating pain or inflammation, the method comprising:
 locally injecting a solid drug depot comprising clonidine and a sustained release biopolymer to an epidural space or an intrathecal space, wherein the pain comprises sciatica.   
     
     
         3 . The method of  claim 2 , wherein the biopolymer comprises polylactide. 
     
     
         4 . The method of  claim 2 , wherein the biopolymer comprises polylactide, and wherein locally injecting the solid drug depot comprises injecting the depot through a needle. 
     
     
         5 . A method of treating pain or inflammation, the method comprising:
 locally administering a solid drug depot comprising clonidine and a biopolymer to an epidural space or an intrathecal space.   
     
     
         6 . The method of  claim 5 , wherein the pain comprises sciatica. 
     
     
         7 . The method of  claim 5 , wherein administering the solid drug depot comprises a local injection. 
     
     
         8 . The method of  claim 5 , wherein the biopolymer comprises a sustained release biopolymer. 
     
     
         9 . The method of  claim 5 , wherein the biopolymer comprises polylactide. 
     
     
         10 . The method of  claim 5 , wherein the pain comprises sciatica, wherein the biopolymer comprises polylactide, and wherein administering the depot comprises injecting the depot through a needle. 
     
     
         11 . The method of  claim 5 , wherein the pain comprises sciatica, wherein the biopolymer comprises polylactide, and wherein administering the solid drug depot comprises a local injection. 
     
     
         12 . A method of treating pain or inflammation, the method comprising:
 locally administering a drug depot comprising clonidine to an epidural space or an intrathecal space.   
     
     
         13 . The method of  claim 12 , wherein the pain comprises sciatica. 
     
     
         14 . The method of  claim 12 , wherein administering the drug depot comprises a local injection. 
     
     
         15 . The method of  claim 12 , wherein the drug depot comprises a biopolymer. 
     
     
         16 . The method of  claim 12 , wherein the biopolymer comprises a sustained release biopolymer. 
     
     
         17 . The method of  claim 12 , wherein the biopolymer comprises polylactide. 
     
     
         18 . The method of  claim 12 , wherein the depot is solid. 
     
     
         19 . The method of  claim 12 , wherein the depot comprises a matrix or a pill. 
     
     
         20 . The method of  claim 12 , wherein the pain comprises sciatica, wherein the biopolymer comprises polylactide, and wherein administering the drug depot comprises a local injection. 
     
     
         21 . The method of  claim 12 , wherein the pain comprises sciatica, wherein the biopolymer comprises polylactide, wherein administering the depot comprises injecting the depot through a needle, and wherein the depot is solid.

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