Compositions for treatment of xerostomia and for tooth treatment

Abstract

The present application provides an oral care composition comprising: a) emu oil; and one or more of the following: b) one or more emulsifying agents; c) one or more protease enzymes; d) one or more soluble calcium phosphate remineralizing agents; e) one or more whitening agents.

What is claimed is: 
     
         1 . An oral care composition comprising:
 a) emu oil;   and one or more of the following:   b) one or more emulsifying agents;   c) one or more protease enzymes;   d) one or more soluble calcium phosphate remineralizing agents;   e) one or more whitening agents.   
     
     
         2 . The composition of  claim 1  comprising:
 a) emu oil; 
 and two or more of the following: 
 b) one or more emulsifying agents; 
 c) one or more protease enzymes; 
 d) one or more soluble calcium phosphate remineralizing agents; 
 e) one or more whitening agents. 
 
     
     
         3 . The composition of  claim 2  comprising:
 a) emu oil; 
 and three or more of the following: 
 b) one or more emulsifying agents; 
 c) one or more protease enzymes; 
 d) one or more soluble calcium phosphate remineralizing agents; 
 e) one or more whitening agents. 
 
     
     
         4 . The composition of  claim 3  comprising:
 a) emu oil; 
 b) one or more emulsifying agents; 
 c) one or more protease enzymes; 
 d) one or more soluble calcium phosphate remineralizing agents; 
 e) one or more whitening agents. 
 
     
     
         5 . The composition of  claim 4 , wherein one or more of the protease enzymes are selected from the group consisting of papain, trypsin, chymotrypsin, aminopeptidase, carboxypeptidase, pepsin, and cathepsin. 
     
     
         6 . The composition of  claim 4 , wherein the one or more whitening agents are selected from the group consisting of carbamide peroxide and hydrogen peroxide. 
     
     
         7 . The composition of  claim 4 , wherein the one or more soluble calcium phosphate remineralizing agents are selected from the group consisting of dibasic calcium phosphate, monocalcium phosphate, tricalcium phosphate, and tetracalcium phosphate. 
     
     
         8 . The composition of  claim 7 , wherein the one or more emulsifying agents are phospholipids. 
     
     
         9 . The composition of  claim 8 , wherein the phospholipids are lecithin. 
     
     
         10 . The composition of  claim 4 , wherein the composition further comprises an isomalt. 
     
     
         11 . The composition of  claim 10 , wherein the isomalt is selected from the group consisting of galenIQ™ 720 and galenIQ™ 721. 
     
     
         12 . The composition of  claim 4 , wherein the composition further comprises a disintegrating agent. 
     
     
         13 . The composition of  claim 12 , wherein the disintegrating agent is crospovidone. 
     
     
         14 . The composition of  claim 4 , wherein the composition further comprises magnesium stearate. 
     
     
         15 . The composition of  claim 4 , wherein the composition further comprises glycerin. 
     
     
         16 . The composition of  claim 4 , wherein the composition further comprises fluoride. 
     
     
         17 . The composition of  claim 4 , wherein the remineralizing agent is white in color. 
     
     
         18 . The composition of any one  claims 1 - 17 , wherein the composition is formulated as a tablet, a bilayer tablet, a multilayer tablet, chewing gum, a toothpaste, a lozenge, a powder, a gel, a viscous gel, an ointment, a cream, a liquid, a mouthwash, or a candy. 
     
     
         19 . The composition of  claim 18 , wherein the composition is formulated as a bilayer tablet. 
     
     
         20 . The composition of  claim 19 , wherein the bilayer tablet comprises a rapidly disintegrating layer and a slowly eroding layer. 
     
     
         21 . The composition of  claim 20 , wherein the one or more whitening agents are present only in the rapidly disintegrating layer. 
     
     
         22 . The composition of  claim 20 , wherein the emu oil and the one or more proteases are present only in the slowly eroding layer. 
     
     
         23 . The composition of  claim 20 , wherein the one or more whitening agents are present only in the rapidly disintegrating layer; and the emu oil and the one or more proteases are present only in the slowly eroding layer. 
     
     
         24 . The composition of  claim 23 , wherein the rapidly disintegrating layer comprises carbamide peroxide in an amount between 0.1 to 10.0% by weight. 
     
     
         25 . The composition of  claim 24 , wherein the rapidly disintegrating layer comprises carbamide peroxide in an amount of 1.0% by weight. 
     
     
         26 . The composition of  claim 23 , wherein the slowly eroding layer comprises emu oil in an amount between 0.1 to 15% by weight. 
     
     
         27 . The composition of  claim 26 , wherein the slowly eroding layer comprises emu oil in an amount of 10% by weight. 
     
     
         28 . The composition of  claim 23 , wherein the slowly eroding layer comprises papain in an amount between 0.1 to 20% by weight. 
     
     
         29 . The composition of  claim 27 , wherein the slowly eroding layer comprises papain in an amount of 10% by weight. 
     
     
         30 . A method of treating a subject suffering from xerostomia which comprises administering to the subject, in an amount effective to treat the xerostomia, a composition of any one of  claims 1 - 29 . 
     
     
         31 . The method of  claim 30 , wherein the composition further whitens teeth in the subject's mouth. 
     
     
         32 . The method of  claim 30 , wherein the composition further remineralizes teeth in the subject's mouth. 
     
     
         33 . The method of  claim 30 , wherein the composition further whitens and remineralizes teeth in the subject's mouth. 
     
     
         34 . The method of  claim 30 , wherein the composition further reduces dental sensitivity of the subject. 
     
     
         35 . The method of  claim 30 , wherein the composition further treats dental caries of the subject. 
     
     
         36 . The method of any one of  claims 30 - 35 , wherein the subject is a human. 
     
     
         37 . The method of any one of  claims 30 - 35 , wherein the subject is a non-human animal. 
     
     
         38 . The method of  claim 36 , wherein the subject has an autoimmune disease, diabetes, Sjögren's syndrome, or has recently undergone radiation therapy or chemotherapy. 
     
     
         39 . The method of  claim 36 , wherein the subject is concurrently taking one or more medications that causes xerostomia. 
     
     
         40 . An oral care composition for whitening teeth comprising one or more whitening agents, wherein the composition is formulated as a bilayer tablet comprising:
 (i) a rapidly disintegrating layer; and   (ii) a slowly eroding layer,   wherein the one or more whitening agents are each oxidizing agents and are each present only in the rapidly disintegrating layer.   
     
     
         41 . The composition of  claim 40 , wherein the one or more whitening agents are selected from the group consisting of carbamide peroxide and hydrogen peroxide. 
     
     
         42 . The composition of  claim 41 , wherein the whitening agent is carbamide peroxide and is present in an amount between 0.1 to 10.0% by weight of the disintegrating layer. 
     
     
         43 . The composition of  claim 41 , wherein the whitening agent is carbamide peroxide and is present in an amount of 1.0% by weight of the disintegrating layer. 
     
     
         44 . The composition of  claim 40 , further comprising one or more of the following:
 a) emu oil;   b) one or more emulsifying agents;   c) one or more protease enzymes;   d) one or more soluble calcium phosphate remineralizing agents.   
     
     
         45 . The composition of  claim 44 , further comprising two or more of the following:
 a) emu oil;   b) one or more emulsifying agents;   c) one or more protease enzymes;   d) one or more soluble calcium phosphate remineralizing agents.   
     
     
         46 . The composition of  claim 45 , further comprising three or more of the following:
 a) emu oil;   b) one or more emulsifying agents;   c) one or more protease enzymes;   d) one or more soluble calcium phosphate remineralizing agents.   
     
     
         47 . The composition of  claim 46 , further comprising each of the following:
 a) emu oil;   b) one or more emulsifying agents;   c) one or more protease enzymes;   d) one or more soluble calcium phosphate remineralizing agents.   
     
     
         48 . The composition of  claim 40 , further comprising:
 a) emu oil;   and one or more of the following:   b) one or more emulsifying agents;   c) one or more protease enzymes;   d) one or more soluble calcium phosphate remineralizing agents.   
     
     
         49 . The composition of  claim 47 , wherein the emu oil, the one or more emulsifying agents, and the one or more protease enzymes are present only in the slowly eroding layer. 
     
     
         50 . The composition of  claim 47 , wherein the one or more soluble calcium phosphate remineralizing agents are present only in the rapidly disintegrating layer. 
     
     
         51 . A method of treating a subject suffering from xerostomia which comprises administering to the subject, in an amount effective to treat the xerostomia, a composition of  claim 48 . 
     
     
         52 . A method of whitening teeth in a subject's mouth which comprises administering to the subject's teeth, in an amount effective to whiten the teeth, a composition of any one of  claims 40 - 50 . 
     
     
         53 . An oral care composition comprising:
 a) one or more omega fatty acids;   and one or more of the following:   b) one or more emulsifying agents;   c) one or more protease enzymes;   d) one or more soluble calcium phosphate remineralizing agents;   e) one or more whitening agents.   
     
     
         54 . The composition of  claim 53  comprising:
 a) one or more omega fatty acids; 
 and two or more of the following: 
 b) one or more emulsifying agents; 
 c) one or more protease enzymes; 
 d) one or more soluble calcium phosphate remineralizing agents; 
 e) one or more whitening agents. 
 
     
     
         55 . The composition of  claim 54  comprising:
 a) one or more omega fatty acids; 
 and three or more of the following: 
 b) one or more emulsifying agents; 
 c) one or more protease enzymes; 
 d) one or more soluble calcium phosphate remineralizing agents; 
 e) one or more whitening agents. 
 
     
     
         56 . The composition of  claim 55  comprising each of the following:
 a) one or more omega fatty acids; 
 b) one or more emulsifying agents; 
 c) one or more protease enzymes; 
 d) one or more soluble calcium phosphate remineralizing agents; 
 e) one or more whitening agents. 
 
     
     
         57 . The composition of any one of  claims 53 - 56 , wherein the one or more omega fatty acids comprise omega-3 fatty acids or omega-6 fatty acids. 
     
     
         58 . The composition of  claim 57 , wherein the omega-3 fatty acid is alpha-linoleic acid and the omega-6 fatty acid is gamma-linoleic acid. 
     
     
         59 . A method of treating a subject suffering from xerostomia which comprises administering to the subject, in an amount effective to treat the xerostomia, a composition of  claim 53 . 
     
     
         60 . A method of whitening teeth in a subject's mouth which comprises administering to the subject's teeth, in an amount effective to whiten the teeth, a composition of  claim 56 .