Cell Adhesion Inhibitor

Abstract

The invention provides a cell adhesion inhibitor comprising, as an active ingredient, a polymer comprising a repeating unit having a sulfinyl group in a side chain thereof.

What is claimed is: 
     
         1 . A surface-modified tool having, on at least a portion of a surface thereof, a polymer comprising a repeating unit represented by the following formula (2): 
       
         
           
           
               
               
           
         
         wherein R 1  represents a hydrogen atom or a methyl group; R 2  represents *—(C═O)—O— (* denotes a position of bonding to a carbon atom to which R 1  is bonded in formula (2)), or a phenylene group; R 3  represents a linkage group represented by the following formula (3) or a C1 to C24 alkanediyl group; and R 4  represents a monovalent group represented by the following formula (5) or a C1 to C10 alkyl group, 
       
       
         
           
           
               
               
           
         
         wherein R 6  represents a single bond, —R 8 —O— (R 8  represents a C1 to C4 alkanediyl group), or a linkage group represented by the following formula (4); R 7  represents a C1 to C4 alkanediyl group; n is 1 or 2; and ** denotes the position of bonding to the sulfur atom in formula (2), 
       
       
         
           
           
               
               
           
         
         wherein R 9  represents a C1 to C4 alkanediyl group; R 10  represents a C2 or C3 alkanediyl group; m 1  is 1 or 2; and m 2  is an integer of 1 to 3, 
       
       
         
           
           
               
               
           
         
         wherein k 1  is an integer of 1 to 4; k 2  is an integer of 0 to 4; and *** denotes the position of bonding to the sulfur atom in formula (2). 
       
     
     
         2 . The surface-modified tool according to  claim 1 , wherein the polymer further comprises a hydrophobic repeating unit. 
     
     
         3 . The surface-modified tool according to  claim 1 , wherein said surface-modified tool is a biomedical structure. 
     
     
         4 . The biomedical structure of  claim 3 , wherein at least the portion of the surface of the biomedical structure is coated with the polymer comprising the repeating unit represented by the formula (2). 
     
     
         5 . The biomedical structure of  claim 4 , wherein biological tissues are not likely to adhere where at least the portion of the biomedical structure is coated with the polymer comprising the repeating unit represented by the formula (2). 
     
     
         6 . The surface-modified tool according to  claim 1 , wherein said surface-modified tool is a microchannel device. 
     
     
         7 . The microchannel device of  claim 6 , wherein at least the portion of the surface of the microchannel device is coated with the polymer comprising the repeating unit represented by the formula (2). 
     
     
         8 . The microchannel device of  claim 7 , wherein biological tissues are not likely to adhere where at least the portion of the biomedical structure is coated with the polymer comprising the repeating unit represented by the formula (2). 
     
     
         9 . A surface-modified apparatus, having on at least a portion of a surface thereof, a polymer comprising a repeating unit represented by the following formula (2): 
       
         
           
           
               
               
           
         
         wherein R 1  represents a hydrogen atom or a methyl group; R 2  represents *—(C═O)—O— (* denotes a position of bonding to a carbon atom to which R 1  is bonded in formula (2)), or a phenylene group; R 3  represents a linkage group represented by the following formula (3) or a C1 to C24 alkanediyl group; and R 4  represents a monovalent group represented by the following formula (5) or a C1 to C10 alkyl group, 
       
       
         
           
           
               
               
           
         
         wherein R 6  represents a single bond, —R 8 —O— (R 8  represents a C1 to C4 alkanediyl group), or a linkage group represented by the following formula (4); R 7  represents a C1 to C4 alkanediyl group; n is 1 or 2; and ** denotes the position of bonding to the sulfur atom in formula (2), 
       
       
         
           
           
               
               
           
         
         wherein R 9  represents a C1 to C4 alkanediyl group; R 10  represents a C2 or C3 alkanediyl group; m 1  is 1 or 2; and m 2  is an integer of 1 to 3, 
       
       
         
           
           
               
               
           
         
         wherein k 1  is an integer of 1 to 4; k 2  is an integer of 0 to 4; and *** denotes the position of bonding to the sulfur atom in formula (2). 
       
     
     
         10 . The surface-modified apparatus according to  claim 9 , wherein the polymer further comprises a hydrophobic repeating unit. 
     
     
         11 . The surface-modified apparatus according to  claim 9 , wherein said surface-modified apparatus is a biomedical structure. 
     
     
         12 . The biomedical structure of  claim 11 , wherein at least the portion of the surface of the biomedical structure is coated with the polymer comprising the repeating unit represented by the formula (2). 
     
     
         13 . The biomedical structure of  claim 12 , wherein biological tissues are not likely to adhere where at least the portion of the biomedical structure is coated with the polymer comprising the repeating unit represented by the formula (2). 
     
     
         14 . The surface-modified apparatus according to  claim 9 , wherein said surface-modified apparatus is a microchannel device. 
     
     
         15 . The microchannel device of  claim 14 , wherein at least the portion of the surface of the microchannel device is coated with the polymer comprising the repeating unit represented by the formula (2). 
     
     
         16 . The microchannel device of  claim 15 , wherein biological tissues are not likely to adhere where at least the portion of the biomedical structure is coated with the polymer comprising the repeating unit represented by the formula (2). 
     
     
         17 . A method of coating at least a portion of a surface of a biomedical structure or a microchannel device with a polymer comprising a repeating unit having a sulfinyl group in a side chain thereof, wherein the method comprising:
 precoating at least the portion of the surface of the biomedical structure or the microchannel device with a sugar-chain polymer or a protein or a peptide or a polyamino acid;   applying the polymer comprising the repeating unit having the sulfinyl group in the side chain onto at least a precoated portion of the surface of the biomedical structure or the microchannel device through a spray coating or a dip coating or a flow coating or a sponge coating or brushing or immersing; and   curing the polymer comprising the repeating unit having the sulfinyl group in the side chain with a cross-linking agent or a crosslinkable monomer;   wherein biological tissues are not likely to adhere where at least the portion of the biomedical structure or the microchannel device are coated with the polymer comprising the repeating unit having the sulfinyl group in the side chain.   
     
     
         18 . The method of  claim 17 , wherein the polymer comprising the repeating unit having a sulfinyl group in a side chain is represented by the following formula (2): 
       
         
           
           
               
               
           
         
         wherein R 1  represents a hydrogen atom or a methyl group; R 2  represents *—(C═O)—O— (* denotes a position of bonding to a carbon atom to which R 1  is bonded in formula (2)), or a phenylene group; R 3  represents a linkage group represented by the following formula (3) or a C1 to C24 alkanediyl group; and R 4  represents a monovalent group represented by the following formula (5) or a C1 to C10 alkyl group, 
       
       
         
           
           
               
               
           
         
         wherein R 6  represents a single bond, —R 8 —O— (R 8  represents a C1 to C4 alkanediyl group), or a linkage group represented by the following formula (4); R 7  represents a C1 to C4 alkanediyl group; n is 1 or 2; and ** denotes the position of bonding to the sulfur atom in formula (2), 
       
       
         
           
           
               
               
           
         
         wherein R 9  represents a C1 to C4 alkanediyl group; R 10  represents a C2 or C3 alkanediyl group; m 1  is 1 or 2; and m 2  is an integer of 1 to 3, 
       
       
         
           
           
               
               
           
         
         wherein k 1  is an integer of 1 to 4; k 2  is an integer of 0 to 4; and *** denotes the position of bonding to the sulfur atom in formula (2). 
       
     
     
         19 . The method of  claim 15 , wherein applying the polymer comprising the repeating unit having the sulfinyl group in the side chain onto at least the precoated portion of the surface of the biomedical structure or the microchannel device comprising optionally mixing the polymer with a solvent. 
     
     
         20 . The method of  claim 17 , wherein the solvent comprising water or methanol or ethanol or isopropylalcohol, mixed with the polymer either solely or in combination.