Devices and methods for endothelialization of magnetic vascular grafts

Abstract

Magnetic vascular grafts and methods for their use are provided herein.

What is claimed is: 
     
         1 . A method for making a porous, magnetic device, comprising:
 providing a solvent containing an uncured polymer, a poragen, and a magnetic sub stance;   providing an elongate mandrel having a length of at least about 3 cm and a diameter of about 100 μm to about 6 mm;   dipping at least a portion of the mandrel into the solvent containing the polymer, poragen, and magnetic substance;   curing the polymer; and   removing the poragen.   
     
     
         2 . The method of  claim 1 , wherein the polymer is polyurethane. 
     
     
         3 . The method of  claim 1 , wherein the poragen is sodium chloride. 
     
     
         4 . The method of  claim 1 , wherein the magnetic substance is cobalt-chrome. 
     
     
         5 . The method of  claim 1 , wherein the solvent is dimethylacetamide. 
     
     
         6 . The method of  claim 1 , further comprising repeating the dipping and curing steps one or more times. 
     
     
         7 . The method of  claim 1 , further comprising winding a thread around the device after a curing step, and subsequently repeating the dipping and curing steps. 
     
     
         8 . The method of  claim 7 , wherein the thread comprises polypropylene. 
     
     
         9 . The method of  claim 8 , wherein the thread is a polypropylene suture thread. 
     
     
         10 . A method for making a porous, magnetic device, comprising:
 providing a nanofiber mesh;   using electrospinning to deposit the mesh onto a rotating elongate mandrel, wherein the mandrel has a length of at least about 3 cm and a diameter of about 10 μm to about 100 μm; and   incorporating a magnetic substance into the deposited mesh.   
     
     
         11 . The method of  claim 10 , wherein the nanofiber mesh is a polyurethane mesh. 
     
     
         12 . The method of  claim 10 , wherein the magnetic substance is cobalt-chrome. 
     
     
         13 . The method of  claim 10 , further comprising incorporating a poragen into the nanofiber mesh. 
     
     
         14 . The method of  claim 13 , wherein the poragen is sodium chloride. 
     
     
         15 . A method for making a magnetic stent-graft, comprising depositing one or more layers of material inside and/or outside of a magnetic stent. 
     
     
         16 . The method of  claim 15 , wherein the depositing comprises electrospinning. 
     
     
         17 . The method of  claim 15 , wherein the one or more layers of material comprise polyurethane. 
     
     
         18 . The method of  claim 15 , wherein the magnetic stent comprises stainless steel.