Pharmaceutical composition in solid extruded form

Abstract

A pharmaceutical composition including an extruded solid and one or more pharmaceuticals or nutraceuticals is provided. The extruded solid includes hydroxypropylmethylcellulose acetate succinate and isomalt.

That which is claimed: 
     
         1 . A pharmaceutical composition comprising an extrudable solid and one or more pharmaceuticals wherein the extrudable solid comprises hydroxypropylmethyl cellulose acetate succinate and isomalt 
     
     
         2 . The pharmaceutical composition of  claim 1 , in the form of a tablet, pellet or granule. 
     
     
         3 . The pharmaceutical composition according to  claim 1 , further comprising a control release agent. 
     
     
         4 . The pharmaceutical composition according to  claim 3  wherein the control release agent is selected from the group consisting of hypromellose, hydroxypropyl cellulose, ethylcellulose, hydroxypropylmethylcellulose phthalate, cellulose acetate phthalate, carboxymethylethylcellulose, methyl methacrylate-methacrylate copolymer, methacrylate-ethyl acrylate copolymer, methacrylate-methyl acrylate-methyl methacrylate copolymer, polyvinyl acetate phthalate and shellac. 
     
     
         5 . The pharmaceutical composition according to  claim 1 , further comprising a disintegrant. 
     
     
         6 . The pharmaceutical composition according to  claim 5  wherein the disintegrant is selected from the group consisting of hydroxypropylcellulose, low-substituted hydroxypropylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, calcium carboxymethylcellulose, crospovidone, croscarmellose sodium, starches; crystalline cellulose, sodium starch glycolate, and alginic acid or a salt thereof. 
     
     
         7 . The pharmaceutical composition according to  claim 1 , further comprising a filler. 
     
     
         8 . The pharmaceutical composition according to  claim 7  wherein the filler comprises lactose, lactose monohydrate, lactitol, saccharose, sorbitol, mannitol, dextrates, dextrins, dextrose, maltodextrin, croscarmellose sodium, silicified microcrystalline cellulose, microcrystalline cellulose, hydroxypropylcellulose, low-substituted hydroxypropylcellulose, hydroxypropylmethylcellulose polymers, hydroxyethylcellulose, sodium carboxymethylcellulose, carboxymethylene, and carboxymethyl hydroxyethylcellulose and mixtures thereof. 
     
     
         9 . The pharmaceutical composition according to  claim 1 , further comprising a binder. 
     
     
         10 . The pharmaceutical composition according to  claim 9 , wherein the binder is selected from the group consisting of polyvinyl pyrrolidone, polyethylene glycol, acacia, alginic acid, agar, calcium carrageenan, cellulose derivatives, dextrin, gelatin, gum arabic, guar gum, tragacanth, sodium alginate, and mixtures thereof. 
     
     
         11 . The pharmaceutical composition according to  claim 1 , further comprising a lubricant. 
     
     
         12 . The pharmaceutical composition according to  claim 11 , wherein the lubricant is selected from the group consisting of stearic acid and pharmaceutically acceptable salts or esters thereof, talc, microcrystalline waxes, glycerides, light mineral oil, polyethylene glycol, silica acid and pharmaceutically acceptable salts or esters thereof, and mixtures thereof. 
     
     
         13 . A pharmaceutical composition comprising:
 a) 10 to 90 percent of an extrudable solid comprising hydroxypropylmethylcellulose acetate succinate and isomalt; and   b) 10 to 90 percent of a pharmaceutical or nutraceutical.   
     
     
         14 . The pharmaceutical composition of  claim 13  further comprising:
 c) 0 to 20 percent of a disintegrant; 
 d) 0 to 80 percent of a filler; 
 e) 0 to 80 percent of a binder; and 
 f) 0 to 1 percent of a lubricant. 
 
     
     
         15 . The pharmaceutical composition according to  claim 14  wherein the disintegrant is selected from the group consisting of hydroxypropylcellulose, low-substituted HPC, carboxymethylcellulose, sodium carboxymethylcellulose, calcium carboxymethylcellulose, crospovidone, croscarmellose sodium, starches; crystalline cellulose, sodium starch glycolate, and alginic acid or a salt thereof. 
     
     
         16 . The pharmaceutical composition according to  claim 14  wherein the filler comprises lactose, lactose monohydrate, lactitol, saccharose, sorbitol, mannitol, dextrates, dextrins, dextrose, maltodextrin, croscarmellose sodium, silicified microcrystalline cellulose, microcrystalline cellulose, hydroxypropylcellulose, low-substituted hydroxypropylcellulose, hydroxypropylmethylcellulose polymers, hydroxyethylcellulose, sodium carboxymethylcellulose, carboxymethylene, and carboxymethyl hydroxyethylcellulose and mixtures thereof. 
     
     
         17 . The pharmaceutical composition according to  claim 14  wherein the binder is selected from the group consisting of polyvinyl pyrrolidone, polyethylene glycol, acacia, alginic acid, agar, calcium carrageenan, cellulose derivatives, dextrin, gelatin, gum arabic, guar gum, tragacanth, sodium alginate, and mixtures thereof. 
     
     
         18 . The pharmaceutical composition according to  claim 14  wherein the lubricant is selected from the group consisting of stearic acid and pharmaceutically acceptable salts or esters thereof, talc, microcrystalline waxes, glycerides, light mineral oil, polyethylene glycol, silica acid and pharmaceutically acceptable salts or esters thereof, and mixtures thereof.