Mixed allergen compositions and methods for using the same

Abstract

Mixed allergen compositions of two or more different allergens are provided. In some instances, the mixed allergen compositions include: a nut allergen; an animal allergen; and at least one of: a non-nut plant allergen; a biotic agent; and a vitamin. Also provided are methods of administering the mixed allergen compositions to a subject. The mixed allergen compositions find use in a variety of applications, including health maintenance, immune balance, gut balance, immune support, health improvement and therapeutic applications.

1 . A mixed allergen composition comprising:
 peanut complete allergen; and   at least one animal allergen selected from the group consisting of shrimp complete allergen, cod complete allergen and salmon complete allergen, wherein the peanut complete allergen and at least one animal allergen are at about equal parts by protein mass.   
     
     
         2 . The mixed allergen composition of  claim 1 , wherein the animal allergen is selected from the group consisting of shrimp complete allergen and cod complete allergen, and the shrimp complete allergen, cod complete allergen and the peanut complete allergen are at about equal parts by protein mass. 
     
     
         3 . The mixed allergen composition of  claim 1 , further comprising an allergen selected from the group consisting of an almond allergen, a walnut allergen, a cashew allergen, a hazelnut allergen, a pecan allergen and a pistachio allergen. 
     
     
         4 . The mixed allergen composition of  claim 1 , further comprising a wheat allergen. 
     
     
         5 . The mixed allergen composition of  claim 1 , further comprising an egg allergen. 
     
     
         6 . The mixed allergen composition of  claim 1 , further comprising a crab allergen. 
     
     
         7 . The mixed allergen composition of  claim 1 , further comprising an allergen selected from the group consisting of a sesame allergen and an oat allergen. 
     
     
         8 . The mixed allergen composition of  claim 1 , further comprising a soy allergen. 
     
     
         9 . The mixed allergen composition of  claim 1 , further comprising a milk allergen. 
     
     
         10 . (canceled) 
     
     
         11 . The mixed allergen composition of  claim 1 , further comprising a physiologically acceptable delivery vehicle. 
     
     
         12 . A food product comprising the unit formulation of a mixed allergen composition of  claim 21 . 
     
     
         13 . A method of treating a peanut allergy in a human subject in need thereof, the method comprising administering the unit formulation composition of  claim 19  to the subject. 
     
     
         14 .- 18 . (canceled) 
     
     
         19 . A unit formulation composition for oral administration comprising:
 0.5 mg to 5 g of a mixed allergen composition, by protein mass, wherein the mixed allergen composition comprises:   peanut complete allergen; a nut allergen selected from the group consisting of walnut complete allergen, cashew complete allergen, hazelnut complete allergen and combinations thereof; a soy allergen; and an animal allergen selected from the group consisting of shrimp complete allergen, cod complete allergen, salmon complete allergen and combinations thereof;   about 5 percent to about 95 percent, based on the total unit formulation composition, of a pharmaceutically acceptable carrier.   
     
     
         20 . The unit formulation composition for oral administration of  claim 19 , wherein the mixed allergen composition comprises, by total mass, about 15 mg to about 5000 mg of each allergen. 
     
     
         21 . A unit formulation of a mixed allergen composition comprising: about 15 mg to about 5000 mg cashew;
 about 15 mg to about 5000 mg walnut;   about 15 mg to about 5000 mg peanut;   about 15 mg to about 5000 mg hazelnut;   about 15 mg to about 5000 mg soy;   about 15 mg to about 5000 mg white and/or pink fish; and   about 15 mg to about 5000 mg weight hen's egg.   
     
     
         22 . A unit formulation composition for oral administration comprising the mixed allergen composition of  claim 21  and about 5 percent to about 95 percent, based on the weight of the total unit formulation composition, of a pharmaceutically acceptable carrier. 
     
     
         23 . A unit formulation of a mixed allergen composition comprising:
 about 1 mg to about 15000 mg cashew;   about 1 mg to about 15000 mg walnut;   about 1 mg to about 15000 mg peanut;   about 1 mg to about 15000 mg hazelnut;   about 1 mg to about 15000 mg soy;   about 1 mg to about 15000 mg white and/or pink fish; and   about 1 mg to about 15000 mg weight hen's egg; and   about 5 to about 95 percent, based on the weight of the total unit formulation composition, of a pharmaceutically acceptable carrier.