Retinoid double conjugate compounds, compositions thereof, and methods for treating of skin conditions

Abstract

Provided are methods of treating certain skin conditions in a human in which the skin of the human in need of such treatment is contacted with an effective amount of a particular composition.

1 . A method of treating a skin condition in a human, comprising:
 contacting the skin of the human in need of such treatment with an effective amount of a composition comprising the molecule of formula (Id),   
       
         
           
           
               
               
           
         
         wherein 
         R 3  is H or alkyl consisting of 1 carbon atom, and 
         R 6  is alkyl consisting of 1, 2, 3, or 4 carbon atoms; and 
         wherein the skin condition is aging, dryness, hyperpigmentation, icthyosis, loss of skin elasticity, loss of skin elasticity resiliency, loss of extra cellular matrix components in the skin, reduced dermal volume, reduced epidermal volume, loss of fibroblast activity, sallow complexion, actinic keratoses, or a combination thereof. 
       
     
     
         2 . The method of  claim 1 , wherein the composition further comprises:
 a carrier; and   0.01 to 0.5 wt %, relative to the total weight of the composition, of the molecule of formula Id.   
     
     
         3 . The method of  claim 1 , wherein the composition further comprises:
 an α-hydroxy acid.   
     
     
         4 . The method of  claim 1 , wherein the molecule has the formula (If) 
       
         
           
           
               
               
           
         
       
     
     
         5 . The method of  claim 1 , wherein the molecule has the formula (Ig) 
       
         
           
           
               
               
           
         
       
     
     
         6 . The method of  claim 1 , wherein the molecule of formula (Id) is present in an amount of 0.01 to 0.25 wt %. 
     
     
         7 . The method of  claim 1 , wherein the molecule of formula (Id) is present in an amount of 0.01 to less than 0.2 wt %. 
     
     
         8 . The method of  claim 1 , wherein the molecule of formula (Id) is present in the amount of 0.02 to 0.175 wt %.