Method of treatment for mental disorders

Abstract

The invention relates to a medicament or a method for treating mental disorders, in detail, ADHD comprising lurasidone, or a combination of lurasidone and a D 4 receptor agonist.

1 . (canceled) 
     
     
         2 . A method for evaluating a drug on efficacy for treating ADHD, comprising:
 caring out an ORD test on the drug with a non-human primate.   
     
     
         3 . The method of  claim 2 , wherein the carrying out of the ORD test includes conducting (i)-(iii):
 (i) setting clear cubic boxes with one open side while adjusting a direction of each open side and placing a food reward at one of seven positions with respect to each cubic box including line of sight, left outside, left inside, right outside, right inside, left deep, and right deep, where the position of left deep or right deep corresponds to Difficult task, and the position of line of sight, left outside, left inside, right outside, or right inside corresponds to Easy task.   (ii) placing each cubic box in front of a non-human primate in a cage in an order of Trial number 1 to 17 to test if the non-human primate obtains the food reward, and   
       
         
           
                 
                 
                 
               
                     
                 
                   Trial 
                   Position of the 
                     
                 
                   number 
                   food reward 
                   Level 
                 
                     
                 
                     
                 
                 
                 
                 
               
                   1 
                   Line of sight 
                   Easy 
                 
                   2 
                   Line of sight 
                   Easy 
                 
                   3 
                   Right outside 
                   Easy 
                 
                   4 
                   Right deep 
                   Difficult 
                 
                   5 
                   Right outside 
                   Easy 
                 
                   6 
                   Right inside 
                   Easy 
                 
                   7 
                   Right deep 
                   Difficult 
                 
                   8 
                   Left outside 
                   Easy 
                 
                   9 
                   Left deep 
                   Difficult 
                 
                   10 
                   Left outside 
                   Easy 
                 
                   11 
                   Left inside 
                   Easy 
                 
                   12 
                   Left deep 
                   Difficult 
                 
                   13 
                   Left deep 
                   Difficult 
                 
                   14 
                   Right deep 
                   Difficult 
                 
                   15 
                   Left deep 
                   Difficult 
                 
                   16 
                   Right deep 
                   Difficult 
                 
                   17 
                   Line of sight 
                   Easy 
                 
                     
                 
             
                
                
                
                
               
               
                
               
            
             
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
               
            
           
         
         (iii) recording as correct when the non-human primate obtains the food reward in one trial, while recording as incorrect when the non-human primate obtains the food reward in a second trial or later, and 
         the carrying out of the ORD test further includes
 administering the drug before and after (i)-(iii) are conducted, and evaluating based on variation of correct % calculated by formula:
   variation of correct %={difference between correct counts in Difficult task (latter value−former value)}/8×100
 
 
 
       
       where the latter value is a count after the administering of the drug, and the former value is a count before the administering of the drug. 
     
     
         4 . The method of  claim 3 , wherein (i)-(iii) are conducted about two hours after the administering of the drug. 
     
     
         5 . The method of  claim 3 , further comprising:
 subjecting the non-human primate to training including (i) and (ii) before the ORD test.   
     
     
         6 . The method of  claim 5 , wherein the training is carried out at least 10 times. 
     
     
         7 . The method of  claim 6 , wherein the training is carried out once a day. 
     
     
         8 . The method of  claim 2 , wherein the non-human primate is a marmoset. 
     
     
         9 . The method of claim wherein the efficacy for treating ADHD is an efficacy for improving attention function in ADHD and/or suppressing impulsiveness. 
     
     
         10 . The method of  claim 3 , wherein the food reward is Baumkuchen.