US2019010504A1PendingUtilityA1

Human alzheimer's disease and traumatic brain injury associated tau variants as biomarkers and methods of use thereof

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Assignee: UNIV ARIZONA STATEPriority: Dec 11, 2015Filed: Dec 9, 2016Published: Jan 10, 2019
Est. expiryDec 11, 2035(~9.4 yrs left)· nominal 20-yr term from priority
Inventors:Michael SierksLalitha VenkataramanWei Xin
A61P 25/28C12N 15/62G01N 2800/2821G01N 33/6896C07K 16/18C07K 1/22G01N 2333/4709G01N 33/53G01N 2800/2871G01N 33/50G01N 2800/00G01N 33/6854G01N 2800/28G01N 33/68G01N 2333/435G01N 33/6857G01N 33/5005G01N 2800/2814G01N 33/5058G01N 33/483G01N 33/487G01N 33/56966G01N 33/6869G01N 33/48C07K 2317/569C07K 2317/24C07K 16/2872C07K 2317/622C07K 14/00C07K 14/435C07K 2317/62C07K 2317/54C07K 14/4711A61K 39/0005C07K 2317/56C07K 16/00A61K 39/395A61K 39/0007
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Claims

Abstract

The present invention provides detection reagents and method for determining risk of traumatic brain injury (TBI) and/or susceptibility to neurodegenerative disease in a subject.

Claims

exact text as granted — not AI-modified
1 - 9 . (canceled) 
     
     
         10 . A nucleic acid encoding an antibody that preferentially recognizes TBI-associated tau, wherein the nucleic acid sequence has at least 95% sequence identity of any one of SEQ ID NO: 41, 43, 45, 47, 49, 51, 53 or 55. 
     
     
         11 - 31 . (canceled)

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