Antibody therapeutics that bind psma

Abstract

There is disclosed compositions and methods relating to or derived from anti-PSMA antibodies. More specifically, there is disclosed fully human antibodies that bind PSMA, PSMA-antibody binding fragments and derivatives of such antibodies, and PSMA-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease. There is further disclosed targeted therapies for treatment of prostate cancer having the disclosed anti-PSMA antibodies and fragments thereof targeting the therapeutic agent or cell.

1 .- 7 . (canceled) 
     
     
         8 . A method for treating prostate cancer, said method comprising administering an effective amount of a fully human anti-PSMA antibody or antigen-binding fragment thereof, that binds to a PSMA epitope, to a subject in need thereof, such that the prostate cancer is treated, wherein the antibody comprising:
 a heavy chain variable domain sequence that is at least 95% identical to the amino acid sequence SEQ ID NO. 1; and   a light chain variable domain sequence that is at least 95% identical to an amino acid sequence selected from the group consisting of: SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4, SEQ ID NO. 5, SEQ ID NO. 6, SEQ ID NO. 8, SEQ ID NO. 8, SEQ ID NO. 9, SEQ ID NO. 10, SEQ ID NO. 11, SEQ ID NO. 12, SEQ ID NO. 13, SEQ ID NO. 14, SEQ ID NO. 15, SEQ ID NO. 16, and SEQ ID NO. 17.   
     
     
         9 . (canceled) 
     
     
         10 . The method for treating prostate cancer of  claim 8 , wherein the cancer is selected from the group consisting of: ovarian cancer, colon cancer, breast cancer, lung cancer, myelomas, neuroblastic-derived CNS tumors, monocytic leukemias, B-cell derived leukemias, T-cell derived leukemias, B-cell derived lymphomas, T-cell derived lymphomas, and mast cell derived tumors. 
     
     
         11 . The method of  claim 8 , wherein the antibody comprises a heavy chain/light chain variable domain sequence selected from the group consisting of: SEQ ID NO. 1/SEQ ID NO. 2, SEQ ID NO. 1/SEQ ID NO. 3, SEQ ID NO. 1/SEQ ID NO. 4, SEQ ID NO. 1/SEQ ID NO. 5, SEQ ID NO. 1/SEQ ID NO. 6, SEQ ID NO. 1/SEQ ID NO. 7, SEQ ID NO. 1/SEQ ID NO. 8, SEQ ID NO. 1/SEQ ID NO. 9, SEQ ID NO. 1/SEQ ID NO. 10, SEQ ID NO. 1/SEQ ID NO. 11, SEQ ID NO. 1/SEQ ID NO. 12, SEQ ID NO. 1/SEQ ID NO. 13, SEQ ID NO. 1/SEQ ID NO. 14, SEQ ID NO. 1/SEQ ID NO. 15, SEQ ID NO. 1/SEQ ID NO. 16, and SEQ ID NO. 1/SEQ ID NO. 17. 
     
     
         12 .- 18 . (canceled) 
     
     
         19 . A method for treating cancer associated with PSMA expression in a human subject in need thereof, comprising administering an effective amount of the anti-PSMA antibody, or antigen-binding fragment thereof, to the subject, such that the cancer is treated, wherein the antibody comprises a heavy chain variable domain comprising complementarity determining regions (CDRs) as set forth in SEQ ID NO. 1; and
 comprises a light chain variable domain comprising CDRs as set forth in a light chain variable region amino acid sequence selected from the group consisting of: SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4, SEQ ID NO. 5, SEQ ID NO. 6, SEQ ID NO. 8, SEQ ID NO. 8, SEQ ID NO. 9, SEQ ID NO. 10, SEQ ID NO. 11, SEQ ID NO. 12, SEQ ID NO. 13, SEQ ID NO. 14, SEQ ID NO. 15, SEQ ID NO. 16, and SEQ ID NO. 17.   
     
     
         20 . The method for treating cancer of  claim 19 , wherein the cancer is selected from the group consisting of: prostate cancer, ovarian cancer, colon cancer, breast cancer, lung cancer, myelomas, neuroblastic-derived CNS tumors, monocytic leukemias, B-cell derived leukemias, T-cell derived leukemias, B-cell derived lymphomas, T-cell derived lymphomas, and mast cell derived tumors. 
     
     
         21 . The method of  claim 19 , wherein the antibody comprises a heavy chain/light chain variable domain sequence selected from the group consisting of: SEQ ID NO. 1/SEQ ID NO. 2, SEQ ID NO. 1/SEQ ID NO. 3, SEQ ID NO. 1/SEQ ID NO. 4, SEQ ID NO. 1/SEQ ID NO. 5, SEQ ID NO. 1/SEQ ID NO. 6, SEQ ID NO. 1/SEQ ID NO. 7, SEQ ID NO. 1/SEQ ID NO. 8, SEQ ID NO. 1/SEQ ID NO. 9, SEQ ID NO. 1/SEQ ID NO. 10, SEQ ID NO. 1/SEQ ID NO. 11, SEQ ID NO. 1/SEQ ID NO. 12, SEQ ID NO. 1/SEQ ID NO. 13, SEQ ID NO. 1/SEQ ID NO. 14, SEQ ID NO. 1/SEQ ID NO. 15, SEQ ID NO. 1/SEQ ID NO. 16, and SEQ ID NO. 1/SEQ ID NO. 17. 
     
     
         22 . The method of  claim 8 , wherein the antigen-binding fragment is a Fab fragment. 
     
     
         23 . The method of  claim 8 , wherein the antibody is a single chain antibody comprising a peptide linker connecting the heavy and light chain variable domains.