US2019010121A1PendingUtilityA1

Compounds and uses thereof for the modulation of hemoblogin

63
Assignee: GLOBAL BLOOD THERAPEUTICS INCPriority: Mar 15, 2013Filed: Sep 11, 2018Published: Jan 10, 2019
Est. expiryMar 15, 2033(~6.6 yrs left)· nominal 20-yr term from priority
Inventors:Qing XuZhe LiStephen L. Gwaltney
C07D 211/22C07D 401/06C07D 241/42C07D 241/04A61P 7/00C07D 265/30C07C 271/16C07D 211/30C07D 295/16C07D 207/48C07D 309/28A61P 43/00C07D 333/38C07D 207/08A61P 7/06C07D 403/06C07D 211/60C07D 279/12C07D 403/12C07D 213/81C07D 211/78C07D 211/20C07D 309/08C07D 207/34C07D 401/12C07D 335/02C07D 211/16A61K 31/445A61K 31/4025A61P 35/00A61P 25/28A61P 17/02A61P 11/00A61K 31/5375A61K 31/4439A61K 31/40
63
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Claims

Abstract

Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

Claims

exact text as granted — not AI-modified
1 .- 19 . (canceled) 
     
     
         20 . A compound of formula: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
       or a tautomer thereof, or a pharmaceutically acceptable salt of each thereof. 
     
     
         21 . A compound of formula: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt of each thereof. 
     
     
         22 . A compound of formula: 
       
         
           
           
               
               
           
         
       
     
     
         23 . A compound of formula: 
       
         
           
           
               
               
           
         
       
     
     
         24 . The compound of  claim 20 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         25 . The compound of  claim 20 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         26 . The compound of  claim 20 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         27 . The compound of  claim 20 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         28 . The compound of  claim 20 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         29 . The compound of  claim 20 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         30 . The compound of  claim 20 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         31 . The compound of  claim 20 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         32 . The compound of  claim 20 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         33 . The compound of  claim 20 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof.

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