US2019008895A1PendingUtilityA1

Methods of treating dna damage

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Assignee: BETH ISRAEL DEACONESS MEDICAL CT INCPriority: Aug 9, 2011Filed: May 3, 2018Published: Jan 10, 2019
Est. expiryAug 9, 2031(~5 yrs left)· nominal 20-yr term from priority
Inventors:Leo E. Otterbein
A61K 33/00F04C 2270/0421A61P 43/00A61N 5/10A61N 2005/1094A61P 35/00
58
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Claims

Abstract

The present invention relates to methods and compositions of treating patients suffering from, or at risk for, DNA damage and to increase life span, i.e., prevent or slow the aging process in all species. The treatment includes administering to the patient a pharmaceutical composition that includes carbon monoxide.

Claims

exact text as granted — not AI-modified
1 .- 13 . (canceled) 
     
     
         14 . A method of administering a genotoxic treatment to a patient, the method comprising:
 (a) administering the genotoxic treatment to the patient; and   (b) before, during, or after step (a), administering to the patient a pharmaceutical composition comprising carbon monoxide in an amount effective to protect cells of the patient,   wherein the genotoxic treatment is radiotherapy or hyperthermia therapy.   
     
     
         15 . The method of  claim 14 , wherein the pharmaceutical composition is administered before step (a). 
     
     
         16 . The method of  claim 14 , wherein the pharmaceutical composition is administered during step (a). 
     
     
         17 . The method of  claim 14 , wherein the pharmaceutical composition is administered after step (a). 
     
     
         18 . The method of  claim 14 , wherein the pharmaceutical composition is administered before, during, and after step (a). 
     
     
         19 . The method of  claim 14 , wherein the genotoxic treatment is radiotherapy. 
     
     
         20 . The method of  claim 14 , wherein the genotoxic treatment is hyperthermia therapy. 
     
     
         21 . The method of  claim 14 , wherein the pharmaceutical composition is in gaseous form and is administered to the patient by inhalation. 
     
     
         22 . The method of  claim 14 , wherein the pharmaceutical composition is in liquid form and is administered to the patient orally. 
     
     
         23 . The method of  claim 14 , wherein the pharmaceutical composition is administered directly to the abdominal cavity of the patient. 
     
     
         24 . The method of  claim 14 , wherein the pharmaceutical composition comprises a carbon monoxide-releasing compound. 
     
     
         25 . The method of  claim 14 , wherein the pharmaceutical composition is administered by an artificial lung. 
     
     
         26 . The method of  claim 14 , wherein the pharmaceutical composition is administered by an extracorporeal membrane gas exchange device. 
     
     
         27 . A method of ameliorating age-related damage to DNA in a patient, the method comprising administering to the patient a pharmaceutical composition comprising an amount of carbon monoxide effective to ameliorate age-related damage to DNA in the patient. 
     
     
         28 . The method of  claim 27 , wherein the pharmaceutical composition is in gaseous form and is administered to the patient by inhalation. 
     
     
         29 . The method of  claim 27 , wherein the pharmaceutical composition is in liquid form and is administered to the patient orally. 
     
     
         30 . The method of  claim 27 , wherein the pharmaceutical composition is administered directly to the abdominal cavity of the patient. 
     
     
         31 . The method of  claim 27 , wherein the pharmaceutical composition comprises a carbon monoxide-releasing compound. 
     
     
         32 . The method of  claim 27 , wherein the pharmaceutical composition is administered by an artificial lung. 
     
     
         33 . The method of  claim 27 , wherein the pharmaceutical composition is administered by an extracorporeal membrane gas exchange device.

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