US2019008891A1PendingUtilityA1

Stabilized aqueous composition comprising chondroitin sulfate and hyaluronic acid

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Assignee: SEIKAGAKU KOGYO CO LTDPriority: Jan 29, 2016Filed: Jan 27, 2017Published: Jan 10, 2019
Est. expiryJan 29, 2036(~9.5 yrs left)· nominal 20-yr term from priority
Inventors:Eiji NogamiAkira KoushinbouNoriko OshimaKota FujiwaraTomoya Sato
A61P 27/02A61K 31/728A61K 47/26A61K 31/737A61K 47/36A61K 9/0048
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Claims

Abstract

The present invention also relates to an aqueous composition which comprises chondroitin sulfate, hyaluronic acid, sorbitol, and a pharmaceutical acceptable carrier.

Claims

exact text as granted — not AI-modified
1 . An aqueous composition which comprises chondroitin sulfate, hyaluronic acid, and a pharmaceutically acceptable carrier and which can be stored at room temperature. 
     
     
         2 . An aqueous composition which comprises chondroitin sulfate, hyaluronic acid, sorbitol, and a pharmaceutically acceptable carrier. 
     
     
         3 . The composition according to  claim 1  or  2 , which comprises 20 to 60 mg/mL of chondroitin sulfate and 10 to 40 mg/mL of hyaluronic acid. 
     
     
         4 . The composition according to any one of  claims 1  to  3 , which comprises chondroitin sulfate and hyaluronic acid as active ingredients, and sorbitol as an additive. 
     
     
         5 . The composition according to any one of  claims 2  to  4 , wherein the sorbitol is D-sorbitol. 
     
     
         6 . The composition according to any one of  claims 1  to  5 , which has a viscosity of 20,000 to 120,000 mPa·s at 25° C. and at a shear rate of 2 s −1 . 
     
     
         7 . The composition according to any one of  claims 2  to  6 , which can be stored at room temperature. 
     
     
         8 . The composition according to any one of  claims 1  to  7 , which is a viscoelastic agent. 
     
     
         9 . The composition according to any one of  claims 1  to  8 , which is an ophthalmic composition. 
     
     
         10 . A method for stabilizing the composition as recited in any one of  claims 1  to  9 , the method comprising including sorbitol in the composition. 
     
     
         11 . A method for producing the composition as recited in any one of  claims 1  to  9 , the method comprising including sorbitol in the composition. 
     
     
         12 . A method for storing the composition as recited in any one of  claims 1  to  9 , the method comprising including sorbitol in the composition. 
     
     
         13 . A method for treating an ocular disease, which comprises administering, to a patient in need of an ophthalmic surgical aid in an ophthalmic surgery, an effective amount of the aqueous composition as recited in any one of  claims 1  to  9 . 
     
     
         14 . The method according to  claim 13 , which comprises:
 storing the composition as recited in any one of  claims 1  to  9  at room temperature, and   administering, to a patient in need of an ophthalmic surgical aid in an ophthalmic surgery, an effective amount of the aqueous composition stored at room temperature.   
     
     
         15 . Use of the aqueous composition as recited in any one of  claims 1  to  9  in manufacture of an ophthalmic surgical aid employed in an ophthalmic surgery for treating an ocular disease. 
     
     
         16 . The use according to  claim 15 , wherein the aqueous composition is an aqueous composition for use in an ophthalmic surgery after storage thereof at room temperature. 
     
     
         17 . The aqueous composition according to any one of  claims 1  to  9 , which is for use as an ophthalmic surgical aid employed in an ophthalmic surgery for treating an ocular disease. 
     
     
         18 . The aqueous composition according to  claim 17 , which is for use in an ophthalmic surgery after storage thereof at room temperature.

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