Botulinum toxin for use in the treatment of paratonia

Abstract

The present invention relates to botulinum toxins for use in the treatment of paratonia. In particular, the present invention relates to the treatment of paratonia by local administration of a botulinum toxin to a muscle of a patient.

What is claimed is: 
     
         1 . A botulinum toxin for use in the treatment of paratonia. 
     
     
         2 . The botulinum toxin for use according to  claim 1 , wherein the paratonia has been diagnosed to have a PAI (paratonia assessment instrument) score of ≥3. 
     
     
         3 . The botulinum toxin for use according to  claim 1 , wherein the paratonia affects an upper and/or lower limb. 
     
     
         4 . The botulinum toxin for use according to  claim 1 , wherein the paratonia is associated with cognitive impairment as a result of Alzheimer's disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), subcortical vascular dementia (SVD), or mixed dementia not otherwise specified (NOS). 
     
     
         5 . The botulinum toxin for use according to  claim 1 , wherein the botulinum toxin is locally administered by intramuscular injection. 
     
     
         6 . The botulinum toxin for use according to  claim 1 , wherein the botulinum toxin is administered in an amount of about 10 to 700 Units. 
     
     
         7 . The botulinum toxin for use according to  claim 1 , wherein the botulinum toxin is selected from the group consisting of botulinum toxin types A, B, C 1 , D, E, F, G, and mixtures thereof. 
     
     
         8 . The botulinum toxin for use according to  claim 7 , wherein the botulinum toxin is botulinum toxin type A. 
     
     
         9 . The botulinum toxin for use according to  claim 1 , wherein the botulinum toxin is a botulinum toxin complex or the neurotoxic component of a botulinum toxin complex. 
     
     
         10 . A method of treating paratonia in a patient, the method comprising locally administering a therapeutically effective amount of botulinum toxin to a muscle of the patient.