Use of mcoln-1 modulators to regulate cell migration

Abstract

The present invention relates to the use of modulators of Mcoln-1 for modulating cell migration, in particular the migration of dendritic cells and tumor cells, especially for antitumoral vaccination, autoimmune disease treatment, and metastasis prevention.

1 . A method of modulating cell migration comprising contacting a dendritic cell expressing mucolipin-1 (Mcoln-1) with a small molecule that activates Mcoln-1 and, thereby, stimulating dendritic cell migration. 
     
     
         2 . The method of  claim 1 , said method comprising the administration of the small molecule that activates Mcoln-1 to a subject, thereby stimulating migration of dendritic cells in said subject and administering a vaccine to said subject. 
     
     
         3 . The method of  claim 2 , said method comprising administering the small molecule that activates Mcoln-1 to a subject having an autoimmune disease, thereby stimulating migration of dendritic cells in said subject. 
     
     
         4 . The method of  claim 2 , said method comprising administering the small molecule that activates Mcoln-1 to a subject having a cancer, thereby stimulating migration of dendritic cells in said subject. 
     
     
         5 . The method of  claim 2 , said method comprising administering the small molecule that activates Mcoln-1 to a subject having an infection, thereby stimulating migration of dendritic cells in said subject. 
     
     
         6 . The method of  claim 1 , wherein the small molecule has a molecular mass of less than 1000 Da. 
     
     
         7 . The method of  claim 1 , wherein the dendritic cells are immature dendritic cells.