Compounds, compositions and methods of agelastatin alkaloids

Abstract

The present invention, among other things, provides compounds, compositions and methods for treatment of cancer. In some embodiments, the present invention provides methods for treating blood cancer using agelastatin alkaloids.

1 . A method for treating blood cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula I: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein:
 R 1  is —H or —CH 3 ; 
 R 2  is —OH or —OCH 3 ; 
 R 3  is —H or —OH; and 
 R 4  is —H, or —Br when R 1  is —CH 3 .