Animal pest control method

Abstract

Disclosed is a method for protecting an animal from a parasitic invertebrate pest comprising treating an animal orally or by injection with a pesticidally effective amount of a compound of Formula 1, wherein R 1 is halogen, C 1 -C 3 haloalkyl or C 1 -C 3 haloalkoxy; R 2 is H, halogen, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl or cyano; R 3 is H, halogen, C 1 -C 3 haloalkyl or C 1 -C 3 haloalkoxy; R 4 is halogen, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl or C 1 -C 3 haloalkoxy; R 5 is H, CH 3 , C 2 -C 4 alkylcarbonyl, C 2 -C 4 haloalkylcarbonyl, C 2 -C 5 alkoxycarbonyl or CH 2 O(C 1 -C 3 alkyl); R 6 is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 6 cycloalkyl or C 3 -C 6 halocycloalkyl, each group substituted with one R 7 ; or R 6 is (CH 2 ) m Q; and Q, R 7 , R 8a and R 8b are as defined in the disclosure.

1 - 18 . (canceled) 
     
     
         19 . A method for protecting a mammal from fleas, which comprises orally administering a dosage of about 10 mg/kg to about 100 mg/kg of mammal body weight of an isoxazoline compound having one of the following formulae: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof, 
       
       to the mammal, whereby the dosage is sufficient to protect the mammal from fleas at least 24 hours after oral administration and whereby the mortality to the fleas is at least 50%. 
     
     
         20 . The method according to  claim 19 , wherein the mammal is livestock. 
     
     
         21 . The method according to  claim 19 , wherein the mammal is a canine. 
     
     
         22 . The method according to  claim 19 , wherein the mammal is a feline. 
     
     
         23 . The method according to  claim 19 , wherein the mammal is a cat or a dog. 
     
     
         24 . The method according to  claim 19 , wherein the dosage administered to the mammal is about 10 mg/kg to about 30 mg/kg of mammal body weight. 
     
     
         25 . The method according to  claim 19 , wherein the dosage is administered to the mammal 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12 times a year. 
     
     
         26 . The method according to  claim 19 , wherein the dosage is administered to the mammal once a month. 
     
     
         27 . The method according to  claim 19 , wherein the dosage is administered twice a month.