Method for promoting wound healing by administering a compound which binds ldl-receptor-related protein (lrp) ligand binding domain

Abstract

The present invention relates to the field of therapeutic methods, compositions and uses thereof, that affect, directly or indirectly, the behavior of LRP receptors. These compositions and methods result in the treatment of inflammatory, immunological and metabolic conditions. More particularly, the methods and compositions of the invention are directed to the identification of small molecules, drugs and/or pharmacological agents that affect the Wnt pathway by affecting normal complex formation among various signaling receptors, the LRP5 and LRP6 receptor, and related ligands.

1 . A method for reducing the level of TNF-α in a human patient, comprising:
 administering to a human patient in an amount effective to reduce the level of TNF-α a compound selected from the group consisting of: 
 
       
         
           
           
               
               
           
         
       
     
     
         2 . The method of  claim 1 , wherein the human patient has Diabetes mellitus. 
     
     
         3 . The method of  claim 1 , wherein the compound is 
       
         
           
           
               
               
           
         
       
     
     
         4 . The method of  claim 3 , wherein the human patient has Diabetes mellitus. 
     
     
         5 . The method of  claim 1 , wherein the compound is 
       
         
           
           
               
               
           
         
       
     
     
         6 . The method of  claim 5 , wherein the human patient has Diabetes mellitus. 
     
     
         7 . The method of  claim 1 , wherein the compound is 
       
         
           
           
               
               
           
         
       
     
     
         8 . The method of  claim 7 , wherein the human patient has Diabetes mellitus.