Method of treating bipolar i and ii disorders

Abstract

The present invention relates to a method of treating a patient suffering from a disorder of the central nervous system associated with 5-HT 1A receptor subtype, comprising as an active ingredient a carbostyril derivative or a salt thereof represented by the formula (1) wherein the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or a double bond.

1 - 8 . (canceled) 
     
     
         9 . A method of treating a patient suffering from a disorder of the central nervous system, selected from
 (i) bipolar I disorder with most recent mixed, depressed or unspecified episode, and   (ii) bipolar II disorder with recurrent major depressive episodes with hypomanic episodes,   the method comprises:   administering to said patient a pharmaceutical composition comprising a therapeutically effective amount of a carbostyril compound of formula (1), or a pharmaceutically acceptable salt or solvate thereof, wherein said patient is a mammal:   
       
         
           
           
               
               
           
         
         wherein the carbostyril compound of formula (I) is both a partial D 2  receptor agonist and a partial 5-HT 1A  receptor agonist facilitating treatment of both mania and depression of bipolar I and bipolar II disorders, 
         further wherein the compound of formula (I) is the only antipsychotic administered to said patient. 
       
     
     
         10 . The method of  claim 9 , wherein the disorder is bipolar I disorder as defined in (i). 
     
     
         11 . The method of  claim 9 , wherein the disorder is bipolar II disorder as defined in (ii). 
     
     
         12 . The method according to  claim 9 , wherein the carbostyril compound is 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxyl}-3,4-dihydrocarbostyril. 
     
     
         13 . The method according to  claim 10 , wherein the carbostyril compound is 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxyl}-3,4-dihydrocarbostyril. 
     
     
         14 . The method according to  claim 11 , wherein the carbostyril compound is 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxyl}-3,4-dihydrocarbostyril.