Use of 1,3 diglyceride in a topical composition for countering the weakening of the skin barrier

Abstract

This invention relates to a topical, cosmetic or dermatological composition, comprising a 1,3 diglyceride having the general formula (I), in which the radicals R1 and R2 represent, independently of one another, a C13 to C40 saturated and linear alkyl radical, and at least one cosmetic or dermatological excipient for a topical application on the skin. This invention also relates to such a composition, or a 1,3 diglyceride having the formula (I), for its use in protecting the skin, in countering the weakening of the skin barrier and in preventing or reducing the penetration of exogenous molecules into the skin following a weakening of the skin barrier.

1 - 19 . (canceled) 
     
     
         20 . A topical, cosmetic or dermatological composition comprising a 1,3 diglyceride having the general formula (I): 
       
         
           
           
               
               
           
         
         in which the radicals R 1  and R 2  represent, independently of one another, a C13 to C40 saturated and linear alkyl radical, and at least one cosmetic or dermatological excipient for a topical application on the skin. 
       
     
     
         21 . The composition according to  claim 20 , wherein the radicals R 1  and R 2  represent, independently of one another, a C15 to C23 saturated and linear alkyl radical. 
     
     
         22 . The composition according to  claim 20 , wherein the radicals R 1  and R 2  represent, independently of one another, a C15 to C19 saturated and linear alkyl radical. 
     
     
         23 . The composition according to  claim 20 , wherein R 1  and R 2  are identical. 
     
     
         24 . The composition according to  claim 20 , wherein the 1,3 diglyceride is glyceryl 1,3 dipalmitate, glyceryl 1,3 distearate or a mixture thereof. 
     
     
         25 . The composition according to  claim 20 , wherein the quantity of 1,3 diglyceride is between 0.5% and 10% by weight with respect to the total weight of said composition. 
     
     
         26 . The composition according to  claim 20 , wherein the 1,3 diglyceride is present in the composition in the form of dispersed solid particles. 
     
     
         27 . A method for protecting the skin comprising the administration to a person in need thereof of an effective quantity of a composition according to  claim 20 . 
     
     
         28 . A method for countering the weakening of skin barrier comprising the administration to a person in need thereof of an effective quantity of a composition according to  claim 20 . 
     
     
         29 . The method according to  claim 28 , wherein the skin barrier is weakened under the effect of environmental factors. 
     
     
         30 . The according to  claim 29 , wherein the environmental factor is the cold or heat. 
     
     
         31 . A method for preventing or for reducing the penetration of exogenous molecules into the skin following a weakening of skin barrier comprising the administration to a person in need thereof of an effective quantity of a composition according to  claim 20 . 
     
     
         32 . The method according to  claim 31 , wherein the skin barrier is weakened under the effect of environmental factors. 
     
     
         33 . The method according to  claim 32 , wherein the environmental factor is the cold or heat. 
     
     
         34 . A method for protecting the skin comprising the administration to a person in need thereof of an effective quantity of a 1,3 diglyceride having the general formula (I): 
       
         
           
           
               
               
           
         
         in which the radicals R 1  and R 2  represent, independently of one another, a C13 to C40 saturated and linear alkyl radical. 
       
     
     
         35 . A method for countering the weakening of skin barrier comprising the administration to a person in need thereof of an effective quantity of a 1,3 diglyceride having the general formula (I): 
       
         
           
           
               
               
           
         
         in which the radicals R 1  and R 2  represent, independently of one another, a C13 to C40 saturated and linear alkyl radical. 
       
     
     
         36 . The method according to  claim 35 , wherein the skin barrier is weakened under the effect of environmental factors. 
     
     
         37 . The method according to  claim 36 , wherein the environmental factor is the cold or heat. 
     
     
         38 . A method for preventing or for reducing the penetration of exogenous molecules into the skin following a weakening of skin barrier comprising the administration to a person in need thereof of an effective quantity of a 1,3 diglyceride having the general formula (I): 
       
         
           
           
               
               
           
         
         in which the radicals R 1  and R 2  represent, independently of one another, a C13 to C40 saturated and linear alkyl radical. 
       
     
     
         39 . The method according to  claim 38 , wherein the skin barrier is weakened under the effect of environmental factors. 
     
     
         40 . The method according to  claim 39 , wherein the environmental factor is the cold or heat.