Postprandial gastrokinetic agent

Abstract

To provide a therapeutic agent for gastrointestinal disorder such as diabetic gastroparesis. A postprandial gastrokinetic agent containing (A) ghrelin or a ghrelin agonist and (B) motilin or a motilin agonist as active ingredients, in which both the ingredients (A) and (B) are administered so as to act on the stomach after food intake.

1 . A postprandial gastrokinetic agent, comprising:
 (A) ghrelin or a ghrelin agonist and (B) motilin or a motilin agonist as active ingredients.   
     
     
         2 . A method for enhancing postprandial gastric motility, comprising:
 administering an ingredient (A) which is ghrelin or a ghrelin agonist and an ingredient (B) which is motilin or a motilin agonist to a subject in need thereof such that an effective blood level of each of the ingredients (A) and (B) is achieved after food intake,   wherein after food intake is within about 30 minutes immediately after intake of a meal, and   timing of the administering of each of the ingredients (A) and (B) is determined in consideration of a time to achieve the effective blood level, which is about 20 minutes to about 60 minutes after oral administration and about 10 minutes after intravenous administration.   
     
     
         3 . The method according to  claim 2 , which treats a disease selected from the group consisting of diabetic gastroparesis, postoperative gastroparesis, and functional dyspepsia. 
     
     
         4 . The method according to  claim 2 , which treats diabetic gastroparesis. 
     
     
         5 . The method according to  claim 2 , wherein the administering comprises orally administering the ingredients (A) and (B) from about 30 minutes before to immediately before intake of a meal such that the effective blood level is achieved about 20 minutes to about 60 minutes after oral administration of the ingredients (A) and (B), respectively. 
     
     
         6 . The method according to  claim 5 , wherein the administering comprises orally administering the ingredients (A) and (B) simultaneously. 
     
     
         7 . The method according to  claim 2 , wherein the administering comprises intravenously administering the ingredients (A) and (B) immediately after food intake such that the effective blood level is achieved about 10 minutes after intravenous administration of the ingredients (A) and (B), respectively. 
     
     
         8 . The method according to  claim 7 , wherein the administering comprises intravenously administering the ingredients (A) and (B) simultaneously. 
     
     
         9 . The method according to  claim 2 , which treats postoperative gastroparesis. 
     
     
         10 . The method according to  claim 2 , which treats functional dyspepsia. 
     
     
         11 . A method of treating a human patient having a disease selected from the group consisting of diabetic gastroparesis, postoperative gastroparesis, and functional dyspepsia, comprising:
 administering ghrelin or a ghrelin agonist and motilin or a motilin agonist to the human patient.   
     
     
         12 . The method of  claim 11 , wherein diabetic gastroparesis is treated. 
     
     
         13 . The method of  claim 11 , wherein postoperative gastroparesis is treated. 
     
     
         14 . The method of  claim 11 , wherein functional dyspepsia is treated. 
     
     
         15 . The method of  claim 11 , wherein the administering comprises simultaneously administering ghrelin or a ghrelin agonist and motilin or a motilin agonist.