Pharmaceutical compositions for prevention or treatment of neurodegenerative diseases

Abstract

The present invention relates to methods and compositions for the prevention or treatment of neurodegenerative diseases.

1 - 8 . (canceled) 
     
     
         9 . A method for preventing or treating i) neurodegenerative disease, ii) neurodegenerative complications in a subject suffering from ischemia damage, or iii) mitochondrial disease in a subject in need thereof comprising
 I) a polypeptide comprising
 i) an amino acid sequence ranging from glycine at position 59 to alanine at position 85 in an amino acid sequence SEQ ID NO:1 or, 
 ii) an amino acid sequence having at least 70% identity with the amino acid sequence ranging from glycine at position 59 to alanine at position 85 in the amino acid sequence SEQ ID NO:1, 
 wherein the polypeptide is not the amino acid sequence SEQ ID NO: 1: 
   II) a fusion protein comprising the polypeptide;   III) a nucleic acid sequence encoding the polypeptide or the fusion protein;   IV) a vector comprising the nucleic acid sequence; or   V) a pharmaceutical composition comprising the polypeptide or fusion protein and a pharmaceutically acceptable carrier.   
     
     
         10 . The method of  claim 9  wherein the neurodegenerative disease is selected from the group consisting of Parkinson's disease, Alzheimer's disease and Amyotrophic lateral sclerosis. 
     
     
         11 - 13 . (canceled)