Porcine epidemic diarrhea virus vaccines and methods of use thereof

Abstract

The present disclosure provides an isolated or purified Porcine Epidemic Diarrhea Virus (PEDV) or Porcine Epidemic Diarrhea Virus (PEDV) S1 protein, and methods of use thereof.

1 - 18 . (canceled) 
     
     
         19 . A method of protecting a susceptible pig against Porcine Epidemic Diarrhea Virus (PEDV) infection comprising administering to the pig an effective amount of a composition comprising a Porcine Epidemic Diarrhea Virus (PEDV) and a pharmaceutically-acceptable, non-toxic vehicle, wherein the PEDV has at least 99% identity to SEQ ID NO:1 or SEQ ID NO:2. 
     
     
         20 . The method of  claim 19 , wherein the composition is administered by intramuscular, intradermal, subcutaneous delivery, or via a mucosal surface. 
     
     
         21 . The method of  claim 20 , wherein the composition is administered by subcutaneous or intramuscular injection. 
     
     
         22 . The method of  claim 19 , wherein the composition is administered by oral ingestion. 
     
     
         23 . The method of  claim 19 , wherein the composition is administered intranasally. 
     
     
         24 - 28 . (canceled) 
     
     
         29 . The method of  claim 19 , wherein the composition further comprises an effective amount of an immunological adjuvant. 
     
     
         30 . The method of  claim 19 , wherein the composition further comprises a second immunogenic composition. 
     
     
         31 . The method of  claim 19 , wherein the PEDV has at least 99.9% identity to SEQ ID NO:1 or SEQ ID NO:2. 
     
     
         32 . The method of  claim 19 , wherein the PEDV has at least 99.99% identity to SEQ ID NO:1 or SEQ ID NO:2. 
     
     
         33 . The method of  claim 19 , wherein the PEDV consists of SEQ ID NO:1 or SEQ ID NO:2.