Multicomponent oral care composition

Abstract

The present invention relates to a multicomponent oral health care composition, comprising a source of a fluoride ion, a source of a calcium ion, a source of a phosphate ion, and stabilised chlorine dioxide, that can be used as a toothpaste, oral spray or a mouth wash/oral rinse formulation. The different components in the composition act synergistically together to clean the teeth and mucous membranes of an oral cavity of a subject, perfuming them or protecting them in order to keep them in good condition, change their appearance or correct unpleasant odours. They achieve this by inhibiting caries, promoting teeth remineralisation, and helping to alleviate dentine hypersensitivity, gingivitis and periodontal disease.

1 . An oral care composition for forming fluorapatite in or on teeth comprising:
 i) a source of a fluoride ion;   ii) a source of a calcium ion;   ii) a source of a phosphate ion; and   iv) stabilized chlorine dioxide.   
     
     
         2 . The oral care composition according to  claim 1 , wherein the source of a calcium ion and the source of a phosphate ion is an apatite species. 
     
     
         3 . The oral care composition according to  claim 1 , wherein the source of a calcium ion and the source of a phosphate ion is an apatite species based on the formula M 5 (PO 4 ) 3 X, wherein M is Ca, Sr, Zn or Mg, and X is F, Cl or OH. 
     
     
         4 . The oral care composition according to  claim 2 , wherein the apatite species is a substituted or unsubstituted hydroxyapatite or a substituted or unsubstituted fluorapatite. 
     
     
         5 . The oral care composition according to  claim 2 , wherein the apatite species is selected from calcium hydroxyapatite, strontium hydroxyapatite, calcium hydroxycarbonated apatite, strontium hydroxycarbonated apatite, calcium fluorapatite, strontium fluorapatite, mixed strontium calcium apatites or a mixed hydroxyfluorapatite, zinc substituted hydroxyapatite, zinc carbonated hydroxyapatite, zinc fluorapatite, octacalcium phosphate, or a mixture of any two or more thereof. 
     
     
         6 . The oral care composition according to  claim 2 , wherein the apatite species is present in an amount of from about 0.5 to about 30 weight percent of the composition, and/or the apatite species has a article size distribution, where at least about 3% of the mass of the particles have a size less than about 5 microns and where the apatite species has a crystallite size of less than about 200 nm, as determined using Scherrer Line Broadening. 
     
     
         7 . The oral care composition according to  claim 1 , wherein the source of a fluoride ion is selected from sodium fluoride, potassium fluoride, disodium monofluorophosphate, tin (II) fluoride, dipotassium fluorophosphates, calcium fluorophosphates, calcium fluoride, ammonium fluoride, aluminium fluoride, hexadecyl ammonium fluoride, 3-(N-hexadecyl-N-2-hydroxyethylammonio) ammonium difluoride, N,N′,N′-tris(polyoxyethylene)-N-hexadecylpropylenediaminedihydrofuloride disodium hexafluorosilicate, disodium hexafluorosilicate, dipotassiumhexafluorosilicate, ammonium hexafluorosilicate, magnesium hexafluorosilicate or ammonium fluorophosphates, or any combinations of two or more thereof. 
     
     
         8 . The oral care composition according to  claim 1 , wherein the source of a fluoride ion has a concentration between 20 and 1500 ppm as fluorine. 
     
     
         9 . The oral care composition according to  claim 1 , wherein when the composition is to be used as toothpaste, the fluoride concentration is between 300 and 1500 ppm. 
     
     
         10 . The oral care composition according to  claim 1 , wherein when the composition is to be used as mouth wash, the compositions has an active fluoride concentration between 5 and 500 ppm. 
     
     
         11 . The oral care composition according to  claim 1 , further comprising a buffer system. cm  12 . The oral care composition according to  claim 1 , wherein the buffer system comprises one or more selected from acetate, carbonate, citrate or phosphate-containing species. 
     
     
         13 . The oral care composition according to  claim 1 , wherein the pH of the composition is between about 6.0 and about 8.0. 
     
     
         14 . The oral care composition according to  claim 1 , wherein the composition is a mouth wash or oral rinse, and further comprises a linear polysaccharide polymer. 
     
     
         15 . The oral care composition according to  claim 14 , wherein the linear polysaccharide polymer is a linear polysaccharide gum, wherein one or more hydroxyl groups on a monosaccharide of the linear polysaccharide gum is substituted with a function group comprising a group selected from a carboxyl group (R—COOH), an acyl group (RCO—) or a sulphate group (R—OSO 3   − ). 
     
     
         16 . (canceled) 
     
     
         17 . A toothpaste, oral spray, mouthwash or oral rinse formulation comprising an oral care composition according  claim 1 . 
     
     
         18 . A method for generating gaseous chlorine dioxide within an oral cavity of a subject for a medical purpose comprising, combining stabilized chorine dioxide solution, an apatite species, and a source of a fluoride ion. 
     
     
         19 . The method according to  claim 18 , wherein the stabilized chlorine dioxide solution has a concentration of between about 0.05% to about 2.0% (w/v). 
     
     
         20 . The method according to  claim 18 , wherein the medical purpose is cleaning teeth and mucous membranes, perfuming teeth and mucous membranes, protecting teeth and mucous membranes, change the appearance of teeth and mucous membranes, correct unpleasant odours, remineralization of teeth, dentine hypersensitivity, or a combination of medical purposes. 
     
     
         21 . A method of cleaning teeth and mucous membranes of an oral cavity of a subject, or perfuming them or protecting them, comprising applying an oral care composition according to  claim 1 .