Liquid formulation

Abstract

An electronic cigarette liquid formulation (e-liquid) comprising cannabidiol, a stabiliser and a liquid carrier; wherein the liquid carrier comprises 60-100% v/v propylene glycol, 0-40% v/v glycerol, and 0-40% v/v of one or more triglyceride compounds; and the stabiliser comprises a head portion and a tail portion, wherein the head portion includes one or more reducing moieties and the tail portion comprises a C 3 -C 20 straight or branched aliphatic chain, wherein the stabiliser is soluble or miscible with the liquid carrier.

1 . An electronic cigarette liquid formulation (e-liquid) comprising cannabidiol, a stabiliser and a liquid carrier; wherein the liquid carrier comprises 60-100% v/v propylene glycol, 0-40% v/v glycerol, and 0-40% v/v of one or more triglyceride compounds; and the stabiliser comprises a head portion and a tail portion, wherein the head portion includes one or more reducing moieties and the tail portion comprises a C 3 -C 20  straight or branched aliphatic chain, wherein the stabiliser is soluble or miscible with the liquid carrier. 
     
     
         2 . An electronic cigarette liquid formulation according to  claim 1 , wherein the head portion of the stabiliser includes a hydroxy substituted 5- or 6-membered carbocyclic or heterocyclic ring. 
     
     
         3 . An electronic cigarette liquid formulation according to  claim 2 , wherein the head portion of the stabiliser is derived from ascorbic acid, hydroquinone, hydroxychromane, hydroxyanisole, hydroxytoluene or gallic acid. 
     
     
         4 . An electronic cigarette liquid formulation according to an of  claim 1 , wherein the aliphatic tail of the stabiliser is directly bonded to the head portion or is bonded via a linker group selected from —O—, —O(O)C—, —C(O)—, —N(H)C(O)— and —N(H)—. 
     
     
         5 . An electronic cigarette liquid formulation according to  claim 1 , wherein the stabiliser comprises a head group derived from ascorbic acid, a tail group which is a C 6 -C 20  straight or branched aliphatic chain, and the tail group is connected to the head group via a carboxylate linker group. 
     
     
         6 . An electronic cigarette liquid formulation according to  claim 5 , wherein the stabiliser is an ascorbate ester of a C 7 -C 20  long chain acid. 
     
     
         7 . An electronic cigarette liquid formulation according to  claim 6 , wherein the stabiliser is an ascorbate ester of palmitic acid. 
     
     
         8 . An electronic cigarette liquid formulation according to  claim 1 , wherein the cannabidiol is present in the formulation in an amount of 10 mg/ml to 300 mg/ml. 
     
     
         9 . An electronic cigarette liquid formulation according to  claim 8 , wherein the cannabidiol is present in an amount of 30 mg/ml to 250 mg/ml. 
     
     
         10 . An electronic cigarette liquid formulation according to  claim 9 , wherein the cannabidiol is present in an amount of 50 mg/ml to 200 mg/ml. 
     
     
         11 . An electronic cigarette liquid formulation according to  claim 1 , wherein the stabiliser is present in an amount of 0.05 mg/ml to 5 mg/ml. 
     
     
         12 . An electronic cigarette liquid formulation according to  claim 1 , wherein the ratio of cannabidiol to stabiliser in the mixture is 200:1 to 50:1. 
     
     
         13 . An electronic cigarette liquid formulation according to  claim 1 , wherein the or each triglyceride compound, where present, is derived from a plant source. 
     
     
         14 . An electronic cigarette liquid formulation according to  claim 1 , wherein the formulation further includes nicotine. 
     
     
         15 . An electronic cigarette liquid formulation according to  claim 1 , wherein the formulation further includes a flavouring agent and/or a scent agent. 
     
     
         16 . An electronic cigarette liquid formulation according to  claim 1 , wherein the formulation is substantially free from tetrahydrocannabinol (THC).