Composition comprising melatonin or its derivatives with coenzyme q10 and use thereof against ageing of the skin

Abstract

The invention relates to a composition comprising melatonin, a metabolite or derivative thereof and coenzyme Q10 and to use thereof for the production of a pharmaceutical or cosmetic composition for the treatment of the skin, said composition potentiating the movement of both molecules into the mitochondrion and facilitating percutaneous absorption, in which both the melatonin and the CoQ10 can reach all of the strata of the skin.

1 - 55 . (canceled) 
     
     
         56 . A composition comprising:
 a) coenzyme Q10 at a concentration of 0.3 to 1.0% w/v with respect to the final composition,   b) melatonin at a concentration of 1.0 to 5% w/v with respect to the final composition and   c) at least one antioxidant at a concentration of 0.25 to 0.75% w/v with respect to the final composition.   
     
     
         57 . The composition according to  claim 56 , wherein the melatonin is at a concentration of 1.5 to 3% w/v with respect to the final composition. 
     
     
         58 . The composition according to  claim 56 , wherein the antioxidant is selected from the group consisting of ascorbic acid, sodium ascorbate, tartaric acid, butylhydroxyanisole, citric acid, vitamin A and vitamin E. 
     
     
         59 . The composition according to  claim 56  further comprising at least one gelling agent. 
     
     
         60 . The composition according to  claim 56  further comprising at least one pharmaceutically or cosmetically acceptable vehicle, and/or at least one pharmaceutically or cosmetically acceptable excipient or adjuvant. 
     
     
         61 . A method for treating and preventing cell damage caused by oxidative stress in a patient in need thereof, said method comprising topically administering to the patient the composition according to  claim 56 . 
     
     
         62 . A method for treating and preventing a disease presenting cellular aging in a patient in need thereof, said method comprising topically administering to the patient the composition according to  claim 56 . 
     
     
         63 . The method according to  claim 62 , wherein the disease presenting cellular aging is selected from the group consisting of tumors, cancers, inflammation of tissues and diseases related to the skin. 
     
     
         64 . The method according to  claim 62 , wherein cellular aging is due to exposure to the sun in the skin. 
     
     
         65 . A cosmetic method for anti-aging of the skin of a subject, comprising topical application of an effective amount of the composition according to  claim 56  to the skin of the subject. 
     
     
         66 . The cosmetic method according to  claim 65 , wherein the aging of the skin is caused by the exposure of the skin to the sun's rays. 
     
     
         67 . A sunscreen comprising the composition according to  claim 56  and at least one agent acting as filter for UV-B and UV-A rays. 
     
     
         68 . The composition according to  claim 56 , wherein the antioxidant is tocopherol.