Composition and method for treating wounds and inflammatory conditions

Abstract

Provided, among other things, is a method of treating skin and soft tissue wounds, ulcers, burns, various types of dermatoses, inflammatory conditions of the mucosa, and the like comprising: periodically applying to the wound, inflammatory condition of mucosal tissues, or dermatoses, over a course of day an effective amount of water based formulation (comprising: 0.5 to 5 wt % of an emollient comprising silicone oil, 2 to 10 wt % of fatty acid, humectant(s), emulsifying agent(s), and polymer(s)), wherein the formulation is formulated as a spray, cream, lotion, milk or foam-former.

What is claimed is: 
     
         1 . A method of treating a wound comprising periodically applying to the wound over a course of days an effective amount of a water-based formulation comprising:
 an emollient comprising silicone oil,   a fatty acid,   a titrant,   humectant(s),   emulsifying agents(s),   polymer(s), and   water,   
       wherein the formulation is formulated as a spray, cream, lotion, mild or foam-former, and wherein the formulation lacks an active ingredient. 
     
     
         2 . The method of  claim 1 , wherein the formulation is applied as a foam using a propellant. 
     
     
         3 . The method of  claim 1 , wherein the formulations is essentially free of C1 to C6 alcohols. 
     
     
         4 . The method of  claim 1 , wherein the formulation further comprises a preservative. 
     
     
         5 . The method of  claim 1 , wherein the formulation is free of preservatives. 
     
     
         6 . The method of  claim 1 , wherein the formulation further comprises an alkyl pyridinium chloride surfactant. 
     
     
         7 . The method of  claim 1 , wherein the formulation comprises stearic acid, povidone, propylene glycol, dimethicone, glycerol, triethanol amine and polysorbate 20. 
     
     
         8 . The method of  claim 2 , wherein the formulation must be shaken prior to use. 
     
     
         9 . The method of  claim 8 , wherein the foam is stable at 35° C. for at least 1 min. 
     
     
         10 . The method of  claim 1 , wherein the formulation is non-irritating. 
     
     
         11 . The method of  claim 1 , wherein the formulation is non-sensitizing. 
     
     
         12 . The method of  claim 1 , wherein the formulation is non-comedogenic. 
     
     
         13 . The method of  claim 1 , wherein the wound is selected from the group consisting of incisions, abrasions, laceration, penetration wound, burns, ulcerations, surgical wounds and piercing wounds. 
     
     
         14 . The method of  claim 7 , comprising, by weight % of the composition:
 povidone in an amount in the range of 1.0-3.0%;   stearic acid in an amount in the range of 5.0-8.0%;   propylene glycol in an amount in the range of 4.0-7.0%;   glycerol in an amount in the range of 1.0-2.0%;   dimethicon in an amount in the range of 0.5-5.5%;   triethanol amine in an amount in the range of 0.1-3.0%:   polysorbate 20 in an amount in the range of 1.3-5.0%;   preservative in an amount in the range of 0.0-2.0%; and   water.   
     
     
         15 . The method of  claim 1 , wherein the application of the formulation to the wound is effective to reduce the incidence of erythema and/or edema, reduce the amount of time exudates is present at the site of injury, and/or reduce the amount of time to complete closure of the wound. 
     
     
         16 . The method of  claim 15 , wherein the formulation is also effective to inhibit microbial colonization. 
     
     
         17 . The method of  claim 1 , wherein the formulation is also effective to inhibit microbial colonization by  E. coli  and/or  S. aureus  MRS