Sheet tissue products

Abstract

The present disclosure provides a tissue product comprising a tissue sheet. The sheet can be formed from a plurality of tissue matrix fragments.

What is claimed is: 
     
         1 . A tissue sheet product, comprising:
 a first sheet of material, wherein the first sheet of material comprises a plurality of elongated tissue matrix fragments having a length between 5 μm and 300 μm;   at least one additional sheet of material attached to the first sheet of material, wherein the at least one additional sheet of material comprises a plurality of elongated tissue matrix fragments having a length between 5 μm and 300 μm; and   wherein at least a portion of the plurality of elongated tissue matrix fragments include frayed proximal and distal ends and the elongated tissue matrix fragments are joined to one another at the frayed proximal and distal ends to form the first sheet of material and the at least one additional sheet of material.   
     
     
         2 . The tissue sheet product of  claim 1 , wherein the plurality of elongated tissue matrix fragments are cross-linked to one another. 
     
     
         3 . The tissue sheet product of  claim 2 , wherein the plurality of elongated tissue matrix fragments are cross-linked to one another using a dehydrothermal crosslinking process. 
     
     
         4 . The tissue sheet product of  claim 1 , wherein the plurality of elongated tissue matrix fragments are produced from acellular tissue matrix. 
     
     
         5 . The tissue sheet product of  claim 1 , wherein the first sheet of material and the at least one additional sheet of material swell when contacted with water. 
     
     
         6 . The tissue sheet product of  claim 1 , wherein the each of first sheet of material and the at least one additional sheet of material form a porous structure with open channels that can support cellular ingrowth and vascularization. 
     
     
         7 . The tissue sheet product of  claim 1 , wherein the plurality of elongated tissue matrix fragments are elongated strands of tissue matrix. 
     
     
         8 . The tissue sheet product of  claim 1 , wherein the first sheet of material and the at least one additional sheet of material are dry. 
     
     
         9 . The tissue sheet product of  claim 8 , wherein the plurality of elongated tissue matrix fragments are dried by convective heating. 
     
     
         10 . The tissue sheet product of  claim 1 , wherein the first sheet of material and the at least one additional sheet of material are hydrated and flexible. 
     
     
         11 . The tissue sheet product of  claim 1 , wherein the plurality of elongated tissue matrix fragments of the first sheet of material are oriented in a different direction relative to the plurality of elongated tissue matrix fragments of the at least one additional sheet of material. 
     
     
         12 . The tissue sheet product of  claim 1 , wherein the plurality of elongated tissue matrix fragments are joined without use of substantial amounts of binder or adhesive. 
     
     
         13 . A method of treating a tissue site with a tissue sheet product, comprising:
 selecting a tissue sheet product comprising:
 a first sheet of material; 
 at least one additional sheet of material attached to the first sheet of material; and 
 wherein the first sheet of material and the at least one additional sheet of material comprise a plurality of elongated tissue fragments including frayed proximal and distal ends, the fragments joined to one another at the frayed proximal and distal ends to form the first sheet of material and the at least one additional sheet of material; and 
   placing the tissue sheet product in or on the tissue site.   
     
     
         14 . The method of  claim 13 , further comprising removing tissue from the tissue site before placing the tissue sheet product in or on the tissue site. 
     
     
         15 . The method of  claim 13 , wherein the tissue site is a lumpectomy site. 
     
     
         16 . The method of  claim 13 , wherein the tissue site is selected from at least one of breast, a portion of an abdominal wall, a connective tissue, a tendon, a ligament, dermis, dura, cartilage, bone, gingiva, and adipose tissue. 
     
     
         17 . The method of  claim 13 , wherein the plurality of elongated tissue matrix fragments having a length between 5 μm and 300 μm. 
     
     
         18 . The method of  claim 13 , wherein the plurality of elongated tissue matrix fragments of the first sheet of material are oriented in a different direction relative to the plurality of elongated tissue matrix fragments of the at least one additional sheet of material. 
     
     
         19 . The method of  claim 13 , wherein the tissue matrix includes acellular tissue matrix. 
     
     
         20 . The method of  claim 13 , wherein the tissue product comprises at least two additional sheets of material.