US2018291465A1PendingUtilityA1

Materials and methods for assessment of colorectal adenoma

Assignee: ABBOTT MOLECULAR INCPriority: Mar 14, 2013Filed: Jun 11, 2018Published: Oct 11, 2018

Est. expiryMar 14, 2033(~6.6 yrs left)· nominal 20-yr term from priority

Inventors:Irina A. Sokolova Minghao Song Svetlana Sitailo Frank Policht

G01N 33/57535G01N 2001/305C12Q 2600/158C12Q 2537/16C12Q 1/6806G01N 1/30G01N 33/5091C12Q 2600/106C12Q 1/6841C12Q 1/6886

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Claims

Abstract

Methods of assessing colorectal adenoma, probes, and a kit.

Claims

exact text as granted — not AI-modified

1 .- 8 . (canceled) 
     
     
         9 . A set of detectably labeled probes comprising a locus-specific probe for EGFR (epidermal growth factor receptor), a locus-specific probe for DCC (deleted in colorectal carcinoma), a chromosome enumeration probe for chromosome 18 (CEP18), a locus-specific probe for 13q14 (band 14 on the q arm of chromosome 13), and a locus-specific probe for MYC (c-myc oncogene). 
     
     
         10 . The set of probes of  claim 9 , which further comprises a locus-specific probe for STAT1 (signal transducer and activator of transcription 1) and/or a locus-specific probe for AURKA (aurora kinase A). 
     
     
         11 . A kit for the prognosis of colorectal adenoma in a patient comprising:
 (a) the set of probes of  claim 9  and   (b) instructions for prognosticating colorectal adenoma in a patient   
     
     
         12 . The kit of  claim 11 , which further comprises a locus-specific probe for STAT1 and/or a locus-specific probe for AURKA. 
     
     
         13 .- 15 . (Canceled)

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