Oral Drug Delivery System

Abstract

Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.

1 .- 79 . (canceled) 
     
     
         80 . A method of treating pain in a subject in need thereof, comprising orally administering to the subject an effective amount of a composition comprising:
 an opioid;   sucrose acetate isobutyrate (SAIB);   about 1 weight percent to about 8.6 weight percent of a cellulose acetate butyrate (CAB) having a number average molecular weight ranging from 66,000 Daltons to 83,000 Daltons; and   a solvent.   
     
     
         81 . The method of  claim 80 , wherein the opioid is present in an amount ranging from about 2 mg to about 250 mg. 
     
     
         82 . The method of  claim 80 , wherein the opioid comprises hydrocodone, hydromorphone, levorphanol, morphine, oxymorphone, or oxycodone. 
     
     
         83 . The method of  claim 80 , wherein the composition comprises from about 20 weight percent to about 90 weight percent of the SAIB. 
     
     
         84 . The method of  claim 80 , wherein the CAB has a butyryl content ranging from about 17% to about 38%. 
     
     
         85 . The method of  claim 80 , wherein the CAB has an acetyl content ranging from about 13% to about 30%. 
     
     
         86 . The method of  claim 80 , wherein the CAB has a butyryl content ranging from about 17% to about 38% and an acetyl content ranging from about 13% to about 30%. 
     
     
         87 . The method of  claim 80 , wherein the CAB has at least one feature selected from a butyryl content ranging from about 17% to about 38%, an acetyl content ranging from about 13% to about 30%, and a hydroxyl content ranging from about 0.8% to about 1.7%. 
     
     
         88 . The method of  claim 80 , wherein the composition comprises from about 20 weight percent to about 50 weight percent of the solvent. 
     
     
         89 . The method of  claim 80 , wherein the solvent comprises propylene carbonate, N-methylpyrrolidone (NMP), glycofurol, alpha-tocopherol, diethyl phthalate, or polyethylene glycol 400 (PEG 400). 
     
     
         90 . The method of  claim 80 , wherein the solvent comprises triacetin or ethyl lactate. 
     
     
         91 . The method of  claim 80 , wherein the solvent comprises triacetin. 
     
     
         92 . The method of  claim 80 , wherein the composition further comprises a member selected from caprylic/capric triglyceride, isopropyl myristate (IPM), ethyl oleate, dimethyl phthalate, and benzyl benzoate. 
     
     
         93 . The method of  claim 80 , wherein the composition further comprises isopropyl myristate (IPM). 
     
     
         94 . The method of  claim 93 , wherein the composition comprises from about 1 weight percent to about 75 weight percent of the IPM. 
     
     
         95 . The method of  claim 93 , wherein the composition comprises:
 from about 20 weight percent to about 90 weight percent of the SAIB;   from about 1 weight percent to about 75 weight percent of the IPM; and   from about 20 weight percent to about 50 weight percent of the solvent.   
     
     
         96 . The method of  claim 95 , wherein the composition comprises from 3 weight percent to 7.8 weight percent of the CAB. 
     
     
         97 . The method of  claim 95 , wherein the composition comprises from 0.1 weight percent to 10 weight percent of the IPM. 
     
     
         98 . The method of  claim 95 , wherein the composition comprises:
 from about 30 weight percent to about 70 weight percent of the SAIB;   from about 1 weight percent to about 75 weight percent of the IPM; and   from about 25 weight percent to about 48 weight percent of the solvent.   
     
     
         99 . The method of  claim 80 , wherein the composition is contained in a capsule. 
     
     
         100 . The method of  claim 99 , wherein the capsule comprises gelatin or hydroxyl propylmethyl cellulose. 
     
     
         101 . The method of  claim 99 , wherein the capsule comprises a hard capsule comprising gelatin or hydroxyl propylmethyl cellulose.